Sanogenetic mechanisms of transplantation action of the whole cells and their nuclear fraction on experimental dislipoproteinemia model
Research objective was to compare effects of transplantation of cells and their nucleus on model alimentary dislipoproteinemia. Experiment is executed on the rabbits containing on an atherogenous diet. In blood serum of animals studied changes of a lipide exchange, in a liver — level of stresses-pro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2011-12-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/1496 |
| Summary: | Research objective was to compare effects of transplantation of cells and their nucleus on model alimentary dislipoproteinemia. Experiment is executed on the rabbits containing on an atherogenous diet. In blood serum of animals studied changes of a lipide exchange, in a liver — level of stresses-proteins, morphological changes and the maintenance of markers of an apoptosis and a proliferation. Also estimated the area of atherogenous plaques and a thickness of intima of an aorta. It is shown that unlike cellular transplantation, introduction of nucleus led to more expressed therapeutic effect and inhibition of expansion of leading links of an atherogenesis. |
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| ISSN: | 1682-0363 1819-3684 |