Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple Cultivars
Plant-derived polyphenols exhibit beneficial effects on physiological and pathological processes, including cancer and neurodegenerative disorders, mainly because of their antioxidant activity. Apples are highly enriched in these compounds, mainly in their peel. The Tuscia Red (TR) apple variety exh...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/11/2086 |
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| author | Silvia Bongiorni Ivan Arisi Brunella Ceccantoni Cristina Rossi Camilla Cresta Simona Castellani Ivano Forgione Sara Rinalducci Rosario Muleo Giorgio Prantera |
| author_facet | Silvia Bongiorni Ivan Arisi Brunella Ceccantoni Cristina Rossi Camilla Cresta Simona Castellani Ivano Forgione Sara Rinalducci Rosario Muleo Giorgio Prantera |
| author_sort | Silvia Bongiorni |
| collection | DOAJ |
| description | Plant-derived polyphenols exhibit beneficial effects on physiological and pathological processes, including cancer and neurodegenerative disorders, mainly because of their antioxidant activity. Apples are highly enriched in these compounds, mainly in their peel. The Tuscia Red (TR) apple variety exhibits the peculiar characteristic of depositing high quantities of polyphenols in the pulp, the edible part of the fruit. Since polyphenols, as any natural product, cannot be considered a panacea per se, in this paper, we propose to assess the biological effects of TR flesh extracts, in comparison with two commercial varieties, in a model system, the insect <i>Drosophila melanogaster</i>, largely recognized as a reliable system to test the in vivo effects of natural and synthetic compounds. We performed a comparative, qualitative and quantitative analysis of the polyphenol compositions of the three cultivars and found that TR flesh shows the highest content of polyphenols, and markedly, anthocyanins. Then, we focused on their effects on a panel of physiological, morphometrical, cellular and behavioral phenotypes in wild-type <i>D. melanogaster</i>. We found that all the apple polyphenol extracts showed dose-dependent effects on most of the phenotypes we considered. Remarkably, all the varieties induced a strong relenting of the cell division rate. |
| first_indexed | 2024-03-09T19:19:10Z |
| format | Article |
| id | doaj.art-835429bb9c6846e6b81a78dad93d9849 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T19:19:10Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-835429bb9c6846e6b81a78dad93d98492023-11-24T03:28:59ZengMDPI AGAntioxidants2076-39212022-10-011111208610.3390/antiox11112086Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple CultivarsSilvia Bongiorni0Ivan Arisi1Brunella Ceccantoni2Cristina Rossi3Camilla Cresta4Simona Castellani5Ivano Forgione6Sara Rinalducci7Rosario Muleo8Giorgio Prantera9Department of Ecological and Biological Sciences (DEB), University of Tuscia, 01100 Viterbo, ItalyBioinformatics Facility European Brain Research Institute (EBRI) “Rita Levi-Montalcini”, and Institute of Translational Pharmacology National Research Council (CNR), Viale Regina Elena 295, 00161 Roma, ItalyDepartment for Innovation in Biological, Agro-Food and Forest Systems (DIBAF), University of Tuscia, 01100 Viterbo, ItalyDepartment of Ecological and Biological Sciences (DEB), University of Tuscia, 01100 Viterbo, ItalyDepartment of Ecological and Biological Sciences (DEB), University of Tuscia, 01100 Viterbo, ItalyTree Physiology and Fruit Crop Biotechnology Laboratory, Department of Agriculture and Forest Sciences (DAFNE), University of Tuscia, 01100 Viterbo, ItalyTree Physiology and Fruit Crop Biotechnology Laboratory, Department of Agriculture and Forest Sciences (DAFNE), University of Tuscia, 01100 Viterbo, ItalyDepartment of Ecological and Biological Sciences (DEB), University of Tuscia, 01100 Viterbo, ItalyTree Physiology and Fruit Crop Biotechnology Laboratory, Department of Agriculture and Forest Sciences (DAFNE), University of Tuscia, 01100 Viterbo, ItalyDepartment of Ecological and Biological Sciences (DEB), University of Tuscia, 01100 Viterbo, ItalyPlant-derived polyphenols exhibit beneficial effects on physiological and pathological processes, including cancer and neurodegenerative disorders, mainly because of their antioxidant activity. Apples are highly enriched in these compounds, mainly in their peel. The Tuscia Red (TR) apple variety exhibits the peculiar characteristic of depositing high quantities of polyphenols in the pulp, the edible part of the fruit. Since polyphenols, as any natural product, cannot be considered a panacea per se, in this paper, we propose to assess the biological effects of TR flesh extracts, in comparison with two commercial varieties, in a model system, the insect <i>Drosophila melanogaster</i>, largely recognized as a reliable system to test the in vivo effects of natural and synthetic compounds. We performed a comparative, qualitative and quantitative analysis of the polyphenol compositions of the three cultivars and found that TR flesh shows the highest content of polyphenols, and markedly, anthocyanins. Then, we focused on their effects on a panel of physiological, morphometrical, cellular and behavioral phenotypes in wild-type <i>D. melanogaster</i>. We found that all the apple polyphenol extracts showed dose-dependent effects on most of the phenotypes we considered. Remarkably, all the varieties induced a strong relenting of the cell division rate.https://www.mdpi.com/2076-3921/11/11/2086apple polyphenols<i>Drosophila melanogaster</i>model organismsred flesh applelifespanmitotic index |
| spellingShingle | Silvia Bongiorni Ivan Arisi Brunella Ceccantoni Cristina Rossi Camilla Cresta Simona Castellani Ivano Forgione Sara Rinalducci Rosario Muleo Giorgio Prantera Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple Cultivars Antioxidants apple polyphenols <i>Drosophila melanogaster</i> model organisms red flesh apple lifespan mitotic index |
| title | Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple Cultivars |
| title_full | Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple Cultivars |
| title_fullStr | Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple Cultivars |
| title_full_unstemmed | Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple Cultivars |
| title_short | Apple Polyphenol Diet Extends Lifespan, Slows down Mitotic Rate and Reduces Morphometric Parameters in Drosophila Melanogaster: A Comparison between Three Different Apple Cultivars |
| title_sort | apple polyphenol diet extends lifespan slows down mitotic rate and reduces morphometric parameters in drosophila melanogaster a comparison between three different apple cultivars |
| topic | apple polyphenols <i>Drosophila melanogaster</i> model organisms red flesh apple lifespan mitotic index |
| url | https://www.mdpi.com/2076-3921/11/11/2086 |
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