Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population
Neonicotinoid insecticides (NNIs) are a popular class of insecticides used in various pest management regimens worldwide. Biomonitoring studies continuously report high exposure rates of NNIs in various human populations across the globe. Yet, there is no validated countermeasure for combating the r...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412022000952 |
| _version_ | 1811273196314296320 |
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| author | Collins Nimako Takahiro Ichise Hiroshi Hasegawa Osei Akoto Nathaniel O. Boadi Kumiko Taira Kazutoshi Fujioka Norikazu Isoda Shouta M.M. Nakayama Mayumi Ishizuka Yoshinori Ikenaka |
| author_facet | Collins Nimako Takahiro Ichise Hiroshi Hasegawa Osei Akoto Nathaniel O. Boadi Kumiko Taira Kazutoshi Fujioka Norikazu Isoda Shouta M.M. Nakayama Mayumi Ishizuka Yoshinori Ikenaka |
| author_sort | Collins Nimako |
| collection | DOAJ |
| description | Neonicotinoid insecticides (NNIs) are a popular class of insecticides used in various pest management regimens worldwide. Biomonitoring studies continuously report high exposure rates of NNIs in various human populations across the globe. Yet, there is no validated countermeasure for combating the recent exponential rise in NNI exposure rates observed in human populations. The current study assessed the impacts of organic dietary interventions on NNI exposure rates in a Japanese population. A total of 103 volunteers were recruited into the study. Subjects were either served with Organic diets for 5 and 30 days or conventional diets. A total of 919 repeated urine samples were collected from the participants and then subjected to LC-MS/MS analysis to determine urinary concentrations of 7 NNIs parent compounds and an NNI metabolite. Eight NNIs were detected; with a decreasing detection frequency (%Dfs) pattern; desmethyl-acetamiprid (dm-ACE) (64.96%) > dinotefuran (52.12%), imidacloprid (39.61%) > clothianidin (33.95%) > thiamethoxam (28.51%) > acetamiprid (12.62%) > nitenpyram (5.33%) > thiacloprid (2.83%). Dinotefuran, dm-ACE, and clothianidin recorded the highest concentrations in the subjects. The %Df of NNIs in the 5-days or 30-days organic diet group were lower than those of the conventional diet consumers. The organic diet group showed lower rates of multiple NNI exposures than those of the conventional diet consumers. The mean and median cumulative levels of NNIs (median IMIeq) were significantly lower in the organic diet group than the conventional diet group (p < 0.0001). The estimated daily intakes (EDIs) of NNIs were higher in adults than children, but less than 1% of NNI cRfDs, except for clothianidin, which exhibited a %cRfD of 1.32 in children. Compared to the conventional diet group, the 5- and 30-day organic dietary intervention showed drastic reductions in NNI EDIs. Findings from the present study give credence to organic dietary interventions as potential ameliorative strategies for NNI exposure rates in human populations. |
| first_indexed | 2024-04-12T22:54:45Z |
| format | Article |
| id | doaj.art-835533e0fa234cb0837c3f35aa0ca8c8 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-04-12T22:54:45Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-835533e0fa234cb0837c3f35aa0ca8c82022-12-22T03:13:15ZengElsevierEnvironment International0160-41202022-04-01162107169Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese populationCollins Nimako0Takahiro Ichise1Hiroshi Hasegawa2Osei Akoto3Nathaniel O. Boadi4Kumiko Taira5Kazutoshi Fujioka6Norikazu Isoda7Shouta M.M. Nakayama8Mayumi Ishizuka9Yoshinori Ikenaka10Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, JapanLaboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, JapanFukushima Organic Agriculture Network, 964-0871, 1-511 Narita Cho, Nihonmatsu, Fukushima, JapanChemistry Department, Kwame Nkrumah University of Science and Technology, GhanaChemistry Department, Kwame Nkrumah University of Science and Technology, GhanaDepartment of Anesthesiology, Adachi Medical Center, Tokyo Women’s Medical University, Tokyo, JapanPharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, United StatesLaboratory of Microbiology, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, JapanLaboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, JapanLaboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, JapanLaboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan; Water Research Group, Unit for Environmental Sciences and Management, North-West University, Potchefstroom, South Africa; One Health Research Center, Hokkaido University, Hokkaido, Japan; Translational Research Unit, Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Hokkaido University, Hokkaido, Japan; Corresponding author at: Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 606-0818, Japan.Neonicotinoid insecticides (NNIs) are a popular class of insecticides used in various pest management regimens worldwide. Biomonitoring studies continuously report high exposure rates of NNIs in various human populations across the globe. Yet, there is no validated countermeasure for combating the recent exponential rise in NNI exposure rates observed in human populations. The current study assessed the impacts of organic dietary interventions on NNI exposure rates in a Japanese population. A total of 103 volunteers were recruited into the study. Subjects were either served with Organic diets for 5 and 30 days or conventional diets. A total of 919 repeated urine samples were collected from the participants and then subjected to LC-MS/MS analysis to determine urinary concentrations of 7 NNIs parent compounds and an NNI metabolite. Eight NNIs were detected; with a decreasing detection frequency (%Dfs) pattern; desmethyl-acetamiprid (dm-ACE) (64.96%) > dinotefuran (52.12%), imidacloprid (39.61%) > clothianidin (33.95%) > thiamethoxam (28.51%) > acetamiprid (12.62%) > nitenpyram (5.33%) > thiacloprid (2.83%). Dinotefuran, dm-ACE, and clothianidin recorded the highest concentrations in the subjects. The %Df of NNIs in the 5-days or 30-days organic diet group were lower than those of the conventional diet consumers. The organic diet group showed lower rates of multiple NNI exposures than those of the conventional diet consumers. The mean and median cumulative levels of NNIs (median IMIeq) were significantly lower in the organic diet group than the conventional diet group (p < 0.0001). The estimated daily intakes (EDIs) of NNIs were higher in adults than children, but less than 1% of NNI cRfDs, except for clothianidin, which exhibited a %cRfD of 1.32 in children. Compared to the conventional diet group, the 5- and 30-day organic dietary intervention showed drastic reductions in NNI EDIs. Findings from the present study give credence to organic dietary interventions as potential ameliorative strategies for NNI exposure rates in human populations.http://www.sciencedirect.com/science/article/pii/S0160412022000952Neonicotinoid insecticideOrganic dietConventional dietHealth risk assessmentRelative potency factor (RPF)Estimated daily intakes (EDI) |
| spellingShingle | Collins Nimako Takahiro Ichise Hiroshi Hasegawa Osei Akoto Nathaniel O. Boadi Kumiko Taira Kazutoshi Fujioka Norikazu Isoda Shouta M.M. Nakayama Mayumi Ishizuka Yoshinori Ikenaka Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population Environment International Neonicotinoid insecticide Organic diet Conventional diet Health risk assessment Relative potency factor (RPF) Estimated daily intakes (EDI) |
| title | Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population |
| title_full | Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population |
| title_fullStr | Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population |
| title_full_unstemmed | Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population |
| title_short | Assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a Japanese population |
| title_sort | assessment of ameliorative effects of organic dietary interventions on neonicotinoid exposure rates in a japanese population |
| topic | Neonicotinoid insecticide Organic diet Conventional diet Health risk assessment Relative potency factor (RPF) Estimated daily intakes (EDI) |
| url | http://www.sciencedirect.com/science/article/pii/S0160412022000952 |
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