The protective effect and mechanism of mangiferin on D‐galactose‐induced oxidative stress and cognitive impairment in aging mice by an integrated network pharmacology and experimental validation strategy

The protective effect and mechanism of mangiferin on D‐galactose‐induced oxidative stress and cognitive impairment in aging mice by an integrated network pharmacology and experimental validation strategy

Abstract Mangiferin (MAN) was a natural bioactive xanthone with remarkable antioxidative, anti‐inflammatory, and antiapoptotic effects. The purpose of this study to determine the protective influence of MAN on D‐galactose (D‐gal)‐induced aging and cognitive impairment, together with its underlying m...

Full description

Bibliographic Details
Main Authors:	Jing Zhang, Yanmei Chen, Zhengxuan Wang, Wenbing Zhou, Hafiz Ullah, Jianxin Cao, Yaping Liu, Guiguang Cheng
Format:	Article
Language:	English
Published:	Wiley 2023-12-01
Series:	Food Frontiers
Subjects:	aging cognitive impairment mangiferin network pharmacology oxidative stress pharmacological mechanism
Online Access:	https://doi.org/10.1002/fft2.306

Similar Items

Mangiferin for the Management of Liver Diseases: A Review
by: Lisi Li, et al.
Published: (2023-06-01)

Solubility, Antioxidation, and Oral Bioavailability Improvement of Mangiferin Microparticles Prepared Using the Supercritical Antisolvent Method
by: Mengran Liu, et al.
Published: (2020-01-01)

Inhibition of Peroxidation Potential and Protein Oxidative Damage by Metal Mangiferin Complexes
by: Alberto J. Nuñez-Selles, et al.
Published: (2022-02-01)

Ethosomes and Transethosomes for Mangiferin Transdermal Delivery
by: Maddalena Sguizzato, et al.
Published: (2021-05-01)

Determination of mangiferin solubility in solvents used in the biopharmaceutical industry
by: Jhoany Acosta, et al.
Published: (2016-04-01)

Preparation and evaluation of antidiabetic activity of mangiferin-loaded solid lipid nanoparticles
by: Ahmed I. Foudah, et al.
Published: (2024-04-01)

Nanocrystals of Mangiferin Using Design Expert: Preparation, Characterization, and Pharmacokinetic Evaluation
by: Abdur Rehman Sarwar, et al.
Published: (2023-08-01)

Mangiferin protects rat myocardial tissue against cyclophosphamide induced cardiotoxicity
by: Laxit Bhatt, et al.
Published: (2017-04-01)

The influential factors and non-pharmacological interventions of cognitive impairment in children with ischemic stroke
by: Gang Xu, et al.
Published: (2022-12-01)

NLRP3 inflammasome in cognitive impairment and pharmacological properties of its inhibitors
by: Yi Xu, et al.
Published: (2023-11-01)

Mangiferin Inhibits Apoptosis and Autophagy Induced by Staphylococcus aureus in RAW264.7 Cells
by: Xu J, et al.
Published: (2020-11-01)

Mangiferin as New Potential Anti-Cancer Agent and Mangiferin-Integrated Polymer Systems—A Novel Research Direction
by: Svetlana N. Morozkina, et al.
Published: (2021-01-01)

In-depth analysis of the chemical composition, pharmacological effects, pharmacokinetics, and patent history of mangiferin
by: Monika Kaurav, et al.
Published: (2023-05-01)

Mangiferin reduces uric acid via regulation of amino acid and lipid metabolism
by: Zhongqi Shi, et al.
Published: (2023-09-01)

Ceibinin, a new positional isomer of mangiferin from the inflorescence of Ceiba pentandra (Bombacaceae), elicits similar antioxidant effect but no anti-inflammatory potential compared to mangiferin
by: Bamigboye J. Taiwo, et al.
Published: (2024-01-01)

The Protective Effect of Mangiferin on Formaldehyde-Induced HT22 Cell Damage and Cognitive Impairment
by: Fan Chen, et al.
Published: (2023-05-01)

Nanotechnology-Based Drug Delivery Approaches of Mangiferin: Promises, Reality and Challenges in Cancer Chemotherapy
by: Muhammad Sarfraz, et al.
Published: (2023-08-01)

The Effect of Mangiferin Against Brain Damage Caused by Oxidative Stress and Inflammation Induced by Doxorubicin
by: Soni Siswanto, et al.
Published: (2016-04-01)

Mangiferin attenuates oxidative stress induced renal cell damage through activation of PI3K induced Akt and Nrf-2 mediated signaling pathways
by: Sukanya Saha, et al.
Published: (2016-03-01)

Mangiferin-Loaded Smart Gels for HSV-1 Treatment
by: Mariaconcetta Sicurella, et al.
Published: (2021-08-01)

Impacts of glyphosate and nitrogen sources on the glycation process and dicarbonyl scavenging capacity of mangiferin through the formation of mangiferin-MGO adducts
by: Carlos Eduardo Gonçalves Maia, et al.
Published: (2023-12-01)

Nanostructured Lipid Carriers Aimed to the Ocular Delivery of Mangiferin: In Vitro Evidence
by: Debora Santonocito, et al.
Published: (2023-03-01)

Ginsenoside and Its Therapeutic Potential for Cognitive Impairment
by: Hui Feng, et al.
Published: (2022-09-01)

Pharmacology for pharmacy and the health sciences : a patient-centred approach /
by: 529793 Boarder, Michael, et al.
Published: (c201)

Production of an important antidiabetic compound mangiferin through elicitation in Salacia chinensis under in vivo condition
by: Harichandra A. NIKULE, et al.
Published: (2023-09-01)

Preparation of hydroxyethyl cellulose/ mangiferin edible films and their antimicrobial properties
by: Hebat-Allah S. Tohamy, et al.
Published: (2022-12-01)

Mangiferin enhances the antifungal activities of caspofungin by destroying polyamine accumulation
by: Juan Shen, et al.
Published: (2021-12-01)

Mangiferin Alleviates Postpartum Depression–Like Behaviors by Inhibiting MAPK Signaling in Microglia
by: Meichen Yan, et al.
Published: (2022-06-01)

“Plurethosome” as Vesicular System for Cutaneous Administration of Mangiferin: Formulative Study and 3D Skin Tissue Evaluation
by: Maddalena Sguizzato, et al.
Published: (2021-07-01)

Electrosprayed Nanoparticles Containing Mangiferin-Rich Extract from Mango Leaves for Cosmeceutical Application
by: Vissuta Sirirungsee, et al.
Published: (2023-11-01)

Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats
by: Ohn Mar Lwin, et al.
Published: (2021-11-01)

Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways
by: Arshad Husain Rahmani, et al.
Published: (2023-12-01)

Pharmacology /
by: Randall, Michael D., et al.
Published: (c201)

Pharmacology /
by: Rang, Humphrey P.
Published: (2003)

Mangiferin inhibits chronic stress-induced tumor growth in colorectal liver metastases via WAVE2 signaling pathway
by: Yiming Tao, et al.
Published: (2023-03-01)

Design of Nanotechnological Carriers for Ocular Delivery of Mangiferin: Preformulation Study
by: Debora Santonocito, et al.
Published: (2022-02-01)

Optimization of Ultrasound Assisted Extraction of Mangiferin in Mango (Mangifera indica L.) Kernel
by: Furong ZHU, et al.
Published: (2024-01-01)

Mangiferin content in different parts of mango tree (Mangifera indica L.) in Thailand
by: Ngampuk Tayana, et al.
Published: (2019-06-01)

Mangiferin induces cell death against rhabdomyosarcoma through sustained oxidative stress
by: Vishwanadha Vijaya Padma, et al.
Published: (2015-06-01)

Introduction to pharmacology /
by: 339268 Hollinger, Mannfred A.
Published: (2008)