| Summary: | The target compound, 2-amino-4-(2,3-dichlorophenyl)-6-methoxy-4<i>H</i>-benzo[<i>h</i>]chromene -3-carbonitrile <b>(4)</b>, was synthesized via the reaction of 4-methoxynaphthalen-1-ol <b>(1)</b>, 2,3-dichlorobenzaldehyde <b>(2)</b>, and malononitrile <b>(3)</b> in an ethanolic piperidine solution under microwave irradiation. The synthesized <i>β</i>-enaminonitrile derivative <b>(4)</b> was characterized by spectral data and X-ray diffraction. The in vitro anti-proliferative profile was conducted against five cancer cell lines and was assessed for compound <b>4</b>, which revealed strong and selective cytotoxic potency. This derivative showed promising inhibition efficacy against the EGFR and VEGFR-2 kinases in comparison to Sorafenib as a reference inhibitor. Lastly, the docking analysis into the EGFR and VEGFR-2 active sites was performed to clarify our biological findings.
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