The measurement of serum tumor necrosis factor-alpha levels in patients with lichen planus
Background: Lichen planus is a common mucocutaneous inflammatory skin disease with a multifactorial etiology. Cytokines have a key role in its pathogenesis. In our study, we aimed to investigate the relationship between the disease severity and levels of the tumor necrosis factor alpha (TNF-α) cytok...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Indian Journal of Dermatology |
| Subjects: | |
| Online Access: | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2018;volume=63;issue=4;spage=297;epage=300;aulast=Kara |
| _version_ | 1828416248299388928 |
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| author | Yesim Akpinar Kara |
| author_facet | Yesim Akpinar Kara |
| author_sort | Yesim Akpinar Kara |
| collection | DOAJ |
| description | Background: Lichen planus is a common mucocutaneous inflammatory skin disease with a multifactorial etiology. Cytokines have a key role in its pathogenesis. In our study, we aimed to investigate the relationship between the disease severity and levels of the tumor necrosis factor alpha (TNF-α) cytokine which was considered as a primary cytokine that initiates the cytotoxicity. Materials and Methods: A total of 34 patients with lichen planus who were 18 year or older and gender-matched healthy controls were included in the study. Serum TNF-α levels were measured by human TNF-α enzyme-linked immunosorbent assay test kits and the values in the two groups were statistically compared. Results: The mean serum TNF-α levels were higher in the patient group than that in the control group. Serum TNF-α levels were not associated with oral mucosal involvement and gender. However, it was observed that the level of TNF-α was higher in older ages, both in patient and in control groups. Conclusion: It is thought that TNF-α, a proinflammatory cytokine, may have an important role in the pathogenesis of lichen planus. |
| first_indexed | 2024-12-10T13:59:35Z |
| format | Article |
| id | doaj.art-835c0677ba6741878dd07259eeb67b14 |
| institution | Directory Open Access Journal |
| issn | 0019-5154 1998-3611 |
| language | English |
| last_indexed | 2024-12-10T13:59:35Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Dermatology |
| spelling | doaj.art-835c0677ba6741878dd07259eeb67b142022-12-22T01:45:50ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112018-01-0163429730010.4103/ijd.IJD_474_17The measurement of serum tumor necrosis factor-alpha levels in patients with lichen planusYesim Akpinar KaraBackground: Lichen planus is a common mucocutaneous inflammatory skin disease with a multifactorial etiology. Cytokines have a key role in its pathogenesis. In our study, we aimed to investigate the relationship between the disease severity and levels of the tumor necrosis factor alpha (TNF-α) cytokine which was considered as a primary cytokine that initiates the cytotoxicity. Materials and Methods: A total of 34 patients with lichen planus who were 18 year or older and gender-matched healthy controls were included in the study. Serum TNF-α levels were measured by human TNF-α enzyme-linked immunosorbent assay test kits and the values in the two groups were statistically compared. Results: The mean serum TNF-α levels were higher in the patient group than that in the control group. Serum TNF-α levels were not associated with oral mucosal involvement and gender. However, it was observed that the level of TNF-α was higher in older ages, both in patient and in control groups. Conclusion: It is thought that TNF-α, a proinflammatory cytokine, may have an important role in the pathogenesis of lichen planus.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2018;volume=63;issue=4;spage=297;epage=300;aulast=KaraCytokineslichen planustumor necrosis factor alpha |
| spellingShingle | Yesim Akpinar Kara The measurement of serum tumor necrosis factor-alpha levels in patients with lichen planus Indian Journal of Dermatology Cytokines lichen planus tumor necrosis factor alpha |
| title | The measurement of serum tumor necrosis factor-alpha levels in patients with lichen planus |
| title_full | The measurement of serum tumor necrosis factor-alpha levels in patients with lichen planus |
| title_fullStr | The measurement of serum tumor necrosis factor-alpha levels in patients with lichen planus |
| title_full_unstemmed | The measurement of serum tumor necrosis factor-alpha levels in patients with lichen planus |
| title_short | The measurement of serum tumor necrosis factor-alpha levels in patients with lichen planus |
| title_sort | measurement of serum tumor necrosis factor alpha levels in patients with lichen planus |
| topic | Cytokines lichen planus tumor necrosis factor alpha |
| url | http://www.e-ijd.org/article.asp?issn=0019-5154;year=2018;volume=63;issue=4;spage=297;epage=300;aulast=Kara |
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