Pharmacokinetics, Safety and Pharmacokinetics/Pharmacodynamics Analysis of Omadacycline in Chinese Healthy Subjects

Pharmacokinetics, Safety and Pharmacokinetics/Pharmacodynamics Analysis of Omadacycline in Chinese Healthy Subjects

Objective: Omadacycline is a new type of aminomethylcycline antibiotic, having a broad antibacterial spectrum. But the pharmacokinetic characteristics and safety profile of the Chinese population remain unknown. It is also unclear whether the US-approved treatment regimen is applicable for the Chine...

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Bibliographic Details
Main Authors: Haijing Yang, Zhiwei Huang, Yuancheng Chen, Yusong Zhu, Guoying Cao, Jingjing Wang, Yan Guo, Jicheng Yu, Jufang Wu, Lichuan Liu, Jun Deng, Jing Liu, Harald Reinhart, Jing Zhang, Xiaojie Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
double-peak absorption
compartment model
Monte Carlo simulation
methicillin-resistant Staphylococcus aureus
acute bacterial skin and skin structure infections
community-acquired bacterial pneumonia
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.869237/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.869237/full

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