Secretory TAT-peptide-mediated protein transduction of LIF receptor α-chain distal cytoplasmic motifs into human myeloid HL-60 cells

Secretory TAT-peptide-mediated protein transduction of LIF receptor α-chain distal cytoplasmic motifs into human myeloid HL-60 cells

The distal cytoplasmic motifs of leukemia inhibitory factor receptor α-chain (LIFRα-CT3) can independently induce intracellular myeloid differentiation in acute myeloid leukemia (AML) cells by gene transfection; however, there are significant limitations in the potential clinical u...

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Bibliographic Details
Main Authors: Q. Sun, J. Xiong, J. Lu, S. Xu, Y. Li, X.P. Zhong, G.K. Gao, H.Q. Liu
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2012-10-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Leukemia inhibitory factor
TAT-HIV1
Protein transduction domain
Acute myeloid leukemia
LIF receptor
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001000005

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