Analysis of combined deficiency of interleukin-1 and -6 versus single deficiencies in TNF-mediated arthritis and systemic bone loss

Analysis of combined deficiency of interleukin-1 and -6 versus single deficiencies in TNF-mediated arthritis and systemic bone loss

Aims: Insufficient treatment response in rheumatoid arthritis (RA) patients requires novel treatment strategies to halt disease progression. The potential benefit of combination of cytokine-inhibitors in RA is still unclear and needs further investigation. To explore the impact of combined deficien...

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Bibliographic Details
Main Authors: Silvia Hayer, Birgit Niederreiter, Marlene Kalkgruber, Konrad Wanic, Julia Maißner, Josef S. Smolen, Daniel Aletaha, Stephan Blüml, Kurt Redlich
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2022-07-01
Series:Bone & Joint Research
Subjects:
experimental arthritis
cytokine
inflammatory joint damage
inflammatory systemic bone loss
interleukin
arthritis
osteopenia
il-6
cytokines
tumour necrosis factor
sacroiliitis
inflammatory arthritis
micro-ct
joint damage
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.117.BJR-2021-0481.R1

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