Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice
Amyloid beta peptides and microtubule-associated protein Tau are misfolded and form aggregates in brains of Alzheimer's disease patients. To examine their specific roles in the pathogenesis of Alzheimer's disease and their relevance in neurodegenerative processes, we have created TauPS2APP...
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| Format: | Article |
| Language: | English |
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Elsevier
2010-02-01
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| Series: | Neurobiology of Disease |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996109002459 |
| _version_ | 1818648802221883392 |
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| author | Fiona Grueninger Bernd Bohrmann Christian Czech Theresa Maria Ballard Johann R. Frey Claudia Weidensteiner Markus von Kienlin Laurence Ozmen |
| author_facet | Fiona Grueninger Bernd Bohrmann Christian Czech Theresa Maria Ballard Johann R. Frey Claudia Weidensteiner Markus von Kienlin Laurence Ozmen |
| author_sort | Fiona Grueninger |
| collection | DOAJ |
| description | Amyloid beta peptides and microtubule-associated protein Tau are misfolded and form aggregates in brains of Alzheimer's disease patients. To examine their specific roles in the pathogenesis of Alzheimer's disease and their relevance in neurodegenerative processes, we have created TauPS2APP triple transgenic mice that express human mutated Amyloid Precursor Protein, presenilin 2 and Tau. We present a cross-sectional analysis of these mice at 4, 8, 12 and 16 months of age. By comparing with single transgenic Tau mice, we demonstrate that accumulation of Aβ in TauPS2APP triple transgenic mice impacts on Tau pathology by increasing the phosphorylation of Tau at serine 422, as determined by a novel immunodetection method that is able to reliably measure phospho-Tau species in transgenic mouse brains. The TauPS2APP triple transgenic mouse model will be very useful for studying the effect of new therapeutic paradigms on amyloid deposition and downstream neurofibrillary tangle development. |
| first_indexed | 2024-12-17T01:24:13Z |
| format | Article |
| id | doaj.art-835f463d371247e9b7158af9ab0ff330 |
| institution | Directory Open Access Journal |
| issn | 1095-953X |
| language | English |
| last_indexed | 2024-12-17T01:24:13Z |
| publishDate | 2010-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj.art-835f463d371247e9b7158af9ab0ff3302022-12-21T22:08:45ZengElsevierNeurobiology of Disease1095-953X2010-02-01372294306Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic miceFiona Grueninger0Bernd Bohrmann1Christian Czech2Theresa Maria Ballard3Johann R. Frey4Claudia Weidensteiner5Markus von Kienlin6Laurence Ozmen7F. Hoffmann-La-Roche Ltd, Pharmaceutical Research Neuroscience, CH-4070 Basel, SwitzerlandF. Hoffmann-La-Roche Ltd, Pharmaceutical Research Neuroscience, CH-4070 Basel, SwitzerlandF. Hoffmann-La-Roche Ltd, Pharmaceutical Research Neuroscience, CH-4070 Basel, SwitzerlandF. Hoffmann-La-Roche Ltd, Pharmaceutical Research Neuroscience, CH-4070 Basel, SwitzerlandF. Hoffmann-La-Roche Ltd, Pharmaceutical Research Neuroscience, CH-4070 Basel, SwitzerlandUniklinik Freiburg, Röntgendiagnostik MR-Physik, Hugstetterstr. 55, 79106 Freiburg, GermanyF. Hoffmann-La-Roche Ltd, Pharmaceutical Research Neuroscience, CH-4070 Basel, SwitzerlandF. Hoffmann-La-Roche Ltd, Pharmaceutical Research Neuroscience, CH-4070 Basel, Switzerland; Corresponding author. Fax: +41 616884575.Amyloid beta peptides and microtubule-associated protein Tau are misfolded and form aggregates in brains of Alzheimer's disease patients. To examine their specific roles in the pathogenesis of Alzheimer's disease and their relevance in neurodegenerative processes, we have created TauPS2APP triple transgenic mice that express human mutated Amyloid Precursor Protein, presenilin 2 and Tau. We present a cross-sectional analysis of these mice at 4, 8, 12 and 16 months of age. By comparing with single transgenic Tau mice, we demonstrate that accumulation of Aβ in TauPS2APP triple transgenic mice impacts on Tau pathology by increasing the phosphorylation of Tau at serine 422, as determined by a novel immunodetection method that is able to reliably measure phospho-Tau species in transgenic mouse brains. The TauPS2APP triple transgenic mouse model will be very useful for studying the effect of new therapeutic paradigms on amyloid deposition and downstream neurofibrillary tangle development.http://www.sciencedirect.com/science/article/pii/S0969996109002459Alzheimer's diseaseTauPS2APPTransgenicTauPhosphorylationAβ |
| spellingShingle | Fiona Grueninger Bernd Bohrmann Christian Czech Theresa Maria Ballard Johann R. Frey Claudia Weidensteiner Markus von Kienlin Laurence Ozmen Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice Neurobiology of Disease Alzheimer's disease TauPS2APP Transgenic Tau Phosphorylation Aβ |
| title | Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice |
| title_full | Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice |
| title_fullStr | Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice |
| title_full_unstemmed | Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice |
| title_short | Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice |
| title_sort | phosphorylation of tau at s422 is enhanced by aβ in taups2app triple transgenic mice |
| topic | Alzheimer's disease TauPS2APP Transgenic Tau Phosphorylation Aβ |
| url | http://www.sciencedirect.com/science/article/pii/S0969996109002459 |
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