Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease
Peripheral artery disease (PAD) is caused by occluded or narrowed arteries that reduce blood flow to the lower limbs. The treatment focuses on lifestyle changes, management of modifiable risk factors and vascular surgery. In this review we focus on how Endothelial Cell (EC) dysfunction contributes t...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1054576/full |
| _version_ | 1811226079294128128 |
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| author | Mary M. Kavurma Christina Bursill Christina Bursill Christopher P. Stanley Freda Passam Freda Passam Siân P. Cartland Sanjay Patel Sanjay Patel Jacky Loa Gemma A. Figtree Gemma A. Figtree Jonathan Golledge Jonathan Golledge Sarah Aitken Sarah Aitken David A. Robinson |
| author_facet | Mary M. Kavurma Christina Bursill Christina Bursill Christopher P. Stanley Freda Passam Freda Passam Siân P. Cartland Sanjay Patel Sanjay Patel Jacky Loa Gemma A. Figtree Gemma A. Figtree Jonathan Golledge Jonathan Golledge Sarah Aitken Sarah Aitken David A. Robinson |
| author_sort | Mary M. Kavurma |
| collection | DOAJ |
| description | Peripheral artery disease (PAD) is caused by occluded or narrowed arteries that reduce blood flow to the lower limbs. The treatment focuses on lifestyle changes, management of modifiable risk factors and vascular surgery. In this review we focus on how Endothelial Cell (EC) dysfunction contributes to PAD pathophysiology and describe the largely untapped potential of correcting endothelial dysfunction. Moreover, we describe current treatments and clinical trials which improve EC dysfunction and offer insights into where future research efforts could be made. Endothelial dysfunction could represent a target for PAD therapy. |
| first_indexed | 2024-04-12T09:18:19Z |
| format | Article |
| id | doaj.art-835f614d8bbb416b9e36fccc5793d3dd |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T09:18:19Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-835f614d8bbb416b9e36fccc5793d3dd2022-12-22T03:38:45ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-11-01910.3389/fcvm.2022.10545761054576Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery diseaseMary M. Kavurma0Christina Bursill1Christina Bursill2Christopher P. Stanley3Freda Passam4Freda Passam5Siân P. Cartland6Sanjay Patel7Sanjay Patel8Jacky Loa9Gemma A. Figtree10Gemma A. Figtree11Jonathan Golledge12Jonathan Golledge13Sarah Aitken14Sarah Aitken15David A. Robinson16Heart Research Institute, The University of Sydney, Sydney, NSW, AustraliaSouth Australian Health and Medical Research Institute, Adelaide, SA, AustraliaFaculty of Health and Medical Science, University of Adelaide, Adelaide, SA, AustraliaHeart Research Institute, The University of Sydney, Sydney, NSW, AustraliaHeart Research Institute, The University of Sydney, Sydney, NSW, AustraliaCentral Clinical School, Faculty of Health and Medicine, The University of Sydney, Sydney, NSW, AustraliaHeart Research Institute, The University of Sydney, Sydney, NSW, AustraliaHeart Research Institute, The University of Sydney, Sydney, NSW, AustraliaRoyal Prince Alfred Hospital, Sydney, NSW, AustraliaRoyal Prince Alfred Hospital, Sydney, NSW, AustraliaFaculty of Health and Medicine, The University of Sydney, Sydney, NSW, AustraliaKolling Institute of Medical Research, Royal North Shore Hospital, Sydney, NSW, AustraliaQueensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD, AustraliaThe Department of Vascular and Endovascular Surgery, Townsville University Hospital, Townsville, QLD, AustraliaFaculty of Health and Medicine, The University of Sydney, Sydney, NSW, Australia0Concord Institute of Academic Surgery, Concord Hospital, Sydney, NSW, AustraliaRoyal Prince Alfred Hospital, Sydney, NSW, AustraliaPeripheral artery disease (PAD) is caused by occluded or narrowed arteries that reduce blood flow to the lower limbs. The treatment focuses on lifestyle changes, management of modifiable risk factors and vascular surgery. In this review we focus on how Endothelial Cell (EC) dysfunction contributes to PAD pathophysiology and describe the largely untapped potential of correcting endothelial dysfunction. Moreover, we describe current treatments and clinical trials which improve EC dysfunction and offer insights into where future research efforts could be made. Endothelial dysfunction could represent a target for PAD therapy.https://www.frontiersin.org/articles/10.3389/fcvm.2022.1054576/fullperipheral artery disease (PAD)inflammationtherapeuticsendothelial cell dysfunctionthrombosisangiogenesis |
| spellingShingle | Mary M. Kavurma Christina Bursill Christina Bursill Christopher P. Stanley Freda Passam Freda Passam Siân P. Cartland Sanjay Patel Sanjay Patel Jacky Loa Gemma A. Figtree Gemma A. Figtree Jonathan Golledge Jonathan Golledge Sarah Aitken Sarah Aitken David A. Robinson Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease Frontiers in Cardiovascular Medicine peripheral artery disease (PAD) inflammation therapeutics endothelial cell dysfunction thrombosis angiogenesis |
| title | Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease |
| title_full | Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease |
| title_fullStr | Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease |
| title_full_unstemmed | Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease |
| title_short | Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease |
| title_sort | endothelial cell dysfunction implications for the pathogenesis of peripheral artery disease |
| topic | peripheral artery disease (PAD) inflammation therapeutics endothelial cell dysfunction thrombosis angiogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.1054576/full |
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