Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis*

Cannabinoid (CB2) receptor deficiency reduces the susceptibility of macrophages to oxidized LDL/oxysterol-induced apoptosis*

Macrophage apoptosis is an important process in the pathophysiology of atherosclerosis. Oxidized low-density lipoproteins (OxLDL) are a major component of lesions and potently induce macrophage apoptosis. Cannabinoid receptor 2 (CB2), the predominant macrophage cannabinoid receptor, modulates severa...

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Bibliographic Details
Main Authors: Natalie E. Freeman-Anderson, Theresa G. Pickle, Courtney D. Netherland, Alicia Bales, Nancy E. Buckley, Douglas P. Thewke
Format: Article
Language:English
Published: Elsevier 2008-11-01
Series:Journal of Lipid Research
Subjects:
7-ketocholesterol
Akt
atherosclerosis
caspase-3
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520346113

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