Trends in Choosing Conventional Versus New Antiepileptic Drugs in Epilepsy Treatment
Objectives:An analysis of clinical practice trends in use of conventional drugs to treat epilepsy versus newer antiepileptic drugs (AEDs) was conducted.Methods:Medical records of patients who presented at the clinic with diagnosis of epilepsy 2007-2012 were investigated retrospectively.Results:Data...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2016-08-01
|
| Series: | Archives of Epilepsy |
| Subjects: | |
| Online Access: |
http://archepilepsy.org/archives/archive-detail/article-preview/trends-in-choosing-conventional-versus-new-antiepi/55027
|
| _version_ | 1797767404673040384 |
|---|---|
| author | Gençer GENÇ Özgür ARSLAN Hakan AKGÜN Semai BEK Zeki GÖKÇİL Zeki ODABAŞI |
| author_facet | Gençer GENÇ Özgür ARSLAN Hakan AKGÜN Semai BEK Zeki GÖKÇİL Zeki ODABAŞI |
| author_sort | Gençer GENÇ |
| collection | DOAJ |
| description | Objectives:An analysis of clinical practice trends in use of conventional drugs to treat epilepsy versus newer antiepileptic drugs (AEDs) was conducted.Methods:Medical records of patients who presented at the clinic with diagnosis of epilepsy 2007-2012 were investigated retrospectively.Results:Data of 1126 patients were evaluated. Among them, 624 (55%) patients were treated using monotherapy, 449 (40%) patients received polytherapy, and 53 (5%) patients had no therapy. While 916 (81%) of the patients were using conventional AEDs, 447 (40%) of the patients were using newer AEDs. A total of 887 (79%) of the patients were using either valproate or carbamazepine. Of the 624 patients using monotherapy, 523 (84%) were on conventional AEDs and 101 (16%) patients were taking newer AEDs.Conclusion:In a previous study, the authors found the percentage choosing newer AEDs to be 1% before 1994, 10% in the period 1995– 2000, and 14% in the period 2000–2007. Although the present study indicates that there was an increase (40%) in the use of newer AEDs in 2007–2012, it seems that conventional AEDs are still a first-line treatment choice, at least in Turkish clinical practice. Yet as both epileptologists and patients gain experience with newer AEDs, the trend is likely to change. |
| first_indexed | 2024-03-12T20:39:16Z |
| format | Article |
| id | doaj.art-836122da2d9a497da909fcc3d197ee49 |
| institution | Directory Open Access Journal |
| issn | 2792-0550 |
| language | English |
| last_indexed | 2024-03-12T20:39:16Z |
| publishDate | 2016-08-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Archives of Epilepsy |
| spelling | doaj.art-836122da2d9a497da909fcc3d197ee492023-08-01T11:13:56ZengGalenos YayineviArchives of Epilepsy2792-05502016-08-01222616610.14744/epilepsi.2016.1489013049054Trends in Choosing Conventional Versus New Antiepileptic Drugs in Epilepsy TreatmentGençer GENÇ0Özgür ARSLAN1Hakan AKGÜN2Semai BEK3Zeki GÖKÇİL4Zeki ODABAŞI5 Department of Neurology, Gumussuyu Military Hospital, Istanbul, Turke Department of Neurology, Diyarbakir Military Hospital, Diyarbakir, Turkey Department of Neurology, Gulhane Military Medical Academy, Ankara, Turkey Department of Neurology, Baskent University Adana Training and Research Center, Adana, Turkey Department of Neurology, Gulhane Military Medical Academy, Ankara, Turkey Department of Neurology, Gulhane Military Medical Academy, Ankara, Turkey Objectives:An analysis of clinical practice trends in use of conventional drugs to treat epilepsy versus newer antiepileptic drugs (AEDs) was conducted.Methods:Medical records of patients who presented at the clinic with diagnosis of epilepsy 2007-2012 were investigated retrospectively.Results:Data of 1126 patients were evaluated. Among them, 624 (55%) patients were treated using monotherapy, 449 (40%) patients received polytherapy, and 53 (5%) patients had no therapy. While 916 (81%) of the patients were using conventional AEDs, 447 (40%) of the patients were using newer AEDs. A total of 887 (79%) of the patients were using either valproate or carbamazepine. Of the 624 patients using monotherapy, 523 (84%) were on conventional AEDs and 101 (16%) patients were taking newer AEDs.Conclusion:In a previous study, the authors found the percentage choosing newer AEDs to be 1% before 1994, 10% in the period 1995– 2000, and 14% in the period 2000–2007. Although the present study indicates that there was an increase (40%) in the use of newer AEDs in 2007–2012, it seems that conventional AEDs are still a first-line treatment choice, at least in Turkish clinical practice. Yet as both epileptologists and patients gain experience with newer AEDs, the trend is likely to change. http://archepilepsy.org/archives/archive-detail/article-preview/trends-in-choosing-conventional-versus-new-antiepi/55027 anticonvulsantsepilepsytherapeutics |
| spellingShingle | Gençer GENÇ Özgür ARSLAN Hakan AKGÜN Semai BEK Zeki GÖKÇİL Zeki ODABAŞI Trends in Choosing Conventional Versus New Antiepileptic Drugs in Epilepsy Treatment Archives of Epilepsy anticonvulsants epilepsy therapeutics |
| title | Trends in Choosing Conventional Versus New Antiepileptic Drugs in Epilepsy Treatment |
| title_full | Trends in Choosing Conventional Versus New Antiepileptic Drugs in Epilepsy Treatment |
| title_fullStr | Trends in Choosing Conventional Versus New Antiepileptic Drugs in Epilepsy Treatment |
| title_full_unstemmed | Trends in Choosing Conventional Versus New Antiepileptic Drugs in Epilepsy Treatment |
| title_short | Trends in Choosing Conventional Versus New Antiepileptic Drugs in Epilepsy Treatment |
| title_sort | trends in choosing conventional versus new antiepileptic drugs in epilepsy treatment |
| topic | anticonvulsants epilepsy therapeutics |
| url |
http://archepilepsy.org/archives/archive-detail/article-preview/trends-in-choosing-conventional-versus-new-antiepi/55027
|
| work_keys_str_mv | AT gencergenc trendsinchoosingconventionalversusnewantiepilepticdrugsinepilepsytreatment AT ozgurarslan trendsinchoosingconventionalversusnewantiepilepticdrugsinepilepsytreatment AT hakanakgun trendsinchoosingconventionalversusnewantiepilepticdrugsinepilepsytreatment AT semaibek trendsinchoosingconventionalversusnewantiepilepticdrugsinepilepsytreatment AT zekigokcil trendsinchoosingconventionalversusnewantiepilepticdrugsinepilepsytreatment AT zekiodabasi trendsinchoosingconventionalversusnewantiepilepticdrugsinepilepsytreatment |