Association of polymorphisms of PTEN, AKT1, PI3K, AR, and AMACR genes in patients with prostate cancer
Abstract Polymorphic variants in the PTEN (rs2735343), PI3K (rs2699887), AKT1 (rs2494750), AR (rs17302090), and AMACR (rs3195676) genes were evaluated as possible molecular markers of susceptibility, prognosis, and progression of prostate cancer (PCa), in a case-control study. Samples consisted of 2...
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| Format: | Article |
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Sociedade Brasileira de Genética
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| Series: | Genetics and Molecular Biology |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000500101&lng=en&tlng=en |
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| author | Monyse de Nóbrega Heloisa Lizotti Cilião Marilesia Ferreira de Souza Milene Roldão de Souza Juliana Mara Serpeloni Paulo Emilio Fuganti Ilce Mara de Syllos Cólus |
| author_facet | Monyse de Nóbrega Heloisa Lizotti Cilião Marilesia Ferreira de Souza Milene Roldão de Souza Juliana Mara Serpeloni Paulo Emilio Fuganti Ilce Mara de Syllos Cólus |
| author_sort | Monyse de Nóbrega |
| collection | DOAJ |
| description | Abstract Polymorphic variants in the PTEN (rs2735343), PI3K (rs2699887), AKT1 (rs2494750), AR (rs17302090), and AMACR (rs3195676) genes were evaluated as possible molecular markers of susceptibility, prognosis, and progression of prostate cancer (PCa), in a case-control study. Samples consisted of 277 patients with PCa and 277 controls from Londrina, PR, Brazil. SNPs were analyzed by real-time PCR. A family history of cancer, including PCa, as well as level of schooling were risk factors for PCa. The data were obtained via logistic regression, using odds ratios with a CI 95%. The genotypes of AKT1 and AKT1+AR demonstrated an association with protection for the disease. The combination of SNPs with the histopathological tumor data between allele variants of AMACR, AKT1+AR, and AKT1+AMACR indicated an association with protection against seminal vesicle invasion. The polymorphisms AKT1+AR and PI3K+AR were associated with protection against tumor bilaterality. The genotype combinations PTEN+AMACR and PTEN+AR were associated with the risk of extracapsular extension. Of the five genes studied, two were associated with protection for PCa, four were associated with protection for some prognostic variables, and only one was associated with risk. Thus, these SNPs are candidates for markers to discriminate men with better or worse prognosis for PCa. |
| first_indexed | 2024-12-12T17:53:11Z |
| format | Article |
| id | doaj.art-836408e6bb1141c8b8bf51fea10b3350 |
| institution | Directory Open Access Journal |
| issn | 1415-4757 1678-4685 |
| language | English |
| last_indexed | 2024-12-12T17:53:11Z |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-836408e6bb1141c8b8bf51fea10b33502022-12-22T00:16:47ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1415-47571678-468543310.1590/1678-4685-gmb-2018-0329S1415-47572020000500101Association of polymorphisms of PTEN, AKT1, PI3K, AR, and AMACR genes in patients with prostate cancerMonyse de NóbregaHeloisa Lizotti CiliãoMarilesia Ferreira de SouzaMilene Roldão de SouzaJuliana Mara SerpeloniPaulo Emilio FugantiIlce Mara de Syllos CólusAbstract Polymorphic variants in the PTEN (rs2735343), PI3K (rs2699887), AKT1 (rs2494750), AR (rs17302090), and AMACR (rs3195676) genes were evaluated as possible molecular markers of susceptibility, prognosis, and progression of prostate cancer (PCa), in a case-control study. Samples consisted of 277 patients with PCa and 277 controls from Londrina, PR, Brazil. SNPs were analyzed by real-time PCR. A family history of cancer, including PCa, as well as level of schooling were risk factors for PCa. The data were obtained via logistic regression, using odds ratios with a CI 95%. The genotypes of AKT1 and AKT1+AR demonstrated an association with protection for the disease. The combination of SNPs with the histopathological tumor data between allele variants of AMACR, AKT1+AR, and AKT1+AMACR indicated an association with protection against seminal vesicle invasion. The polymorphisms AKT1+AR and PI3K+AR were associated with protection against tumor bilaterality. The genotype combinations PTEN+AMACR and PTEN+AR were associated with the risk of extracapsular extension. Of the five genes studied, two were associated with protection for PCa, four were associated with protection for some prognostic variables, and only one was associated with risk. Thus, these SNPs are candidates for markers to discriminate men with better or worse prognosis for PCa.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000500101&lng=en&tlng=ensnpprognosisrs2494750rs2735343rs3195676 |
| spellingShingle | Monyse de Nóbrega Heloisa Lizotti Cilião Marilesia Ferreira de Souza Milene Roldão de Souza Juliana Mara Serpeloni Paulo Emilio Fuganti Ilce Mara de Syllos Cólus Association of polymorphisms of PTEN, AKT1, PI3K, AR, and AMACR genes in patients with prostate cancer Genetics and Molecular Biology snp prognosis rs2494750 rs2735343 rs3195676 |
| title | Association of polymorphisms of PTEN, AKT1, PI3K, AR, and AMACR genes in patients with prostate cancer |
| title_full | Association of polymorphisms of PTEN, AKT1, PI3K, AR, and AMACR genes in patients with prostate cancer |
| title_fullStr | Association of polymorphisms of PTEN, AKT1, PI3K, AR, and AMACR genes in patients with prostate cancer |
| title_full_unstemmed | Association of polymorphisms of PTEN, AKT1, PI3K, AR, and AMACR genes in patients with prostate cancer |
| title_short | Association of polymorphisms of PTEN, AKT1, PI3K, AR, and AMACR genes in patients with prostate cancer |
| title_sort | association of polymorphisms of pten akt1 pi3k ar and amacr genes in patients with prostate cancer |
| topic | snp prognosis rs2494750 rs2735343 rs3195676 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000500101&lng=en&tlng=en |
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