Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs
Abstract Ultrasound-based shear wave elastography is a promising technique to non-invasively assess the dynamic stiffness variations of the heart. The technique is based on tracking the propagation of acoustically induced shear waves in the myocardium of which the propagation speed is linked to tiss...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-44588-4 |
| _version_ | 1797452591987163136 |
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| author | Annette Caenen Lana Keijzer Stéphanie Bézy Jürgen Duchenne Marta Orlowska Antonius F. W. Van Der Steen Nico De Jong Johan G. Bosch Jens-Uwe Voigt Jan D’hooge Hendrik J. Vos |
| author_facet | Annette Caenen Lana Keijzer Stéphanie Bézy Jürgen Duchenne Marta Orlowska Antonius F. W. Van Der Steen Nico De Jong Johan G. Bosch Jens-Uwe Voigt Jan D’hooge Hendrik J. Vos |
| author_sort | Annette Caenen |
| collection | DOAJ |
| description | Abstract Ultrasound-based shear wave elastography is a promising technique to non-invasively assess the dynamic stiffness variations of the heart. The technique is based on tracking the propagation of acoustically induced shear waves in the myocardium of which the propagation speed is linked to tissue stiffness. This measurement is repeated multiple times across the cardiac cycle to assess the natural variations in wave propagation speed. The interpretation of these measurements remains however complex, as factors such as loading and contractility affect wave propagation. We therefore applied transthoracic shear wave elastography in 13 pigs to investigate the dependencies of wave speed on pressure–volume derived indices of loading, myocardial stiffness, and contractility, while altering loading and inducing myocardial ischemia/reperfusion injury. Our results show that diastolic wave speed correlates to a pressure–volume derived index of operational myocardial stiffness (R = 0.75, p < 0.001), suggesting that both loading and intrinsic properties can affect diastolic wave speed. Additionally, the wave speed ratio, i.e. the ratio of systolic and diastolic speed, correlates to a pressure–volume derived index of contractility, i.e. preload-recruitable stroke work (R = 0.67, p < 0.001). Measuring wave speed ratio might thus provide a non-invasive index of contractility during ischemia/reperfusion injury. |
| first_indexed | 2024-03-09T15:10:53Z |
| format | Article |
| id | doaj.art-83653814c34a4c1a90b997e7dfba2bef |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:10:53Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-83653814c34a4c1a90b997e7dfba2bef2023-11-26T13:23:44ZengNature PortfolioScientific Reports2045-23222023-10-0113111310.1038/s41598-023-44588-4Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigsAnnette Caenen0Lana Keijzer1Stéphanie Bézy2Jürgen Duchenne3Marta Orlowska4Antonius F. W. Van Der Steen5Nico De Jong6Johan G. Bosch7Jens-Uwe Voigt8Jan D’hooge9Hendrik J. Vos10Department of Cardiology, Erasmus MC University Medical CenterDepartment of Cardiology, Erasmus MC University Medical CenterCardiovascular Imaging and Dynamics Lab, KU LeuvenDepartment of Imaging Physics, Delft University of TechnologyCardiovascular Imaging and Dynamics Lab, KU LeuvenDepartment of Cardiology, Erasmus MC University Medical CenterDepartment of Cardiology, Erasmus MC University Medical CenterDepartment of Cardiology, Erasmus MC University Medical CenterCardiology, KU LeuvenCardiovascular Imaging and Dynamics Lab, KU LeuvenDepartment of Cardiology, Erasmus MC University Medical CenterAbstract Ultrasound-based shear wave elastography is a promising technique to non-invasively assess the dynamic stiffness variations of the heart. The technique is based on tracking the propagation of acoustically induced shear waves in the myocardium of which the propagation speed is linked to tissue stiffness. This measurement is repeated multiple times across the cardiac cycle to assess the natural variations in wave propagation speed. The interpretation of these measurements remains however complex, as factors such as loading and contractility affect wave propagation. We therefore applied transthoracic shear wave elastography in 13 pigs to investigate the dependencies of wave speed on pressure–volume derived indices of loading, myocardial stiffness, and contractility, while altering loading and inducing myocardial ischemia/reperfusion injury. Our results show that diastolic wave speed correlates to a pressure–volume derived index of operational myocardial stiffness (R = 0.75, p < 0.001), suggesting that both loading and intrinsic properties can affect diastolic wave speed. Additionally, the wave speed ratio, i.e. the ratio of systolic and diastolic speed, correlates to a pressure–volume derived index of contractility, i.e. preload-recruitable stroke work (R = 0.67, p < 0.001). Measuring wave speed ratio might thus provide a non-invasive index of contractility during ischemia/reperfusion injury.https://doi.org/10.1038/s41598-023-44588-4 |
| spellingShingle | Annette Caenen Lana Keijzer Stéphanie Bézy Jürgen Duchenne Marta Orlowska Antonius F. W. Van Der Steen Nico De Jong Johan G. Bosch Jens-Uwe Voigt Jan D’hooge Hendrik J. Vos Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs Scientific Reports |
| title | Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs |
| title_full | Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs |
| title_fullStr | Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs |
| title_full_unstemmed | Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs |
| title_short | Continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs |
| title_sort | continuous shear wave measurements for dynamic cardiac stiffness evaluation in pigs |
| url | https://doi.org/10.1038/s41598-023-44588-4 |
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