Recent advances and future challenges of tumor vaccination therapy for recurrent glioblastoma
Abstract Glioblastoma (GBM) is the most malignant CNS tumor with a highest incidence rate, and most patients would undergo a recurrence. Recurrent GBM (rGBM) shows an increasing resistance to chemotherapy and radiotherapy, leading to a significantly poorer prognosis and the urgent need for novel tre...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-04-01
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| Series: | Cell Communication and Signaling |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12964-023-01098-0 |
| _version_ | 1797845820087730176 |
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| author | Binghao Zhao Jiaming Wu Huanzhang Li Yuekun Wang Yaning Wang Hao Xing Yu Wang Wenbin Ma |
| author_facet | Binghao Zhao Jiaming Wu Huanzhang Li Yuekun Wang Yaning Wang Hao Xing Yu Wang Wenbin Ma |
| author_sort | Binghao Zhao |
| collection | DOAJ |
| description | Abstract Glioblastoma (GBM) is the most malignant CNS tumor with a highest incidence rate, and most patients would undergo a recurrence. Recurrent GBM (rGBM) shows an increasing resistance to chemotherapy and radiotherapy, leading to a significantly poorer prognosis and the urgent need for novel treatments. Immunotherapy, a rapidly developing anti-tumor therapy in recent years, has shown its potential value in rGBM. Recent studies on PD-1 immunotherapy and CAR-T therapy have shown some efficacy, but the outcome was not as expected. Tumor vaccination is the oldest approach of immunotherapies, which has returned to the research focus because of the failure of other strategies and subversive understanding of CNS. The isolation effect of blood brain barrier and the immunosuppressive cell infiltration could lead to resistance existing in all phases of the anti-tumor immune response, where novel tumor vaccines have been designed to overcome these problems through new tumor antigenic targets and regulatory of the systematic immune response. In this review, the immunological characteristics of CNS and GBM would be discussed and summarized, as well as the mechanism of each novel tumor vaccine for rGBM. And through the review of completed early-phase studies and ongoing large-scale phase III clinical trials, evaluation could be conducted for potential immune response, biosecurity and initial clinical outcome, which further draw a panorama of this vital research field and provide some deep thoughts for the prospective tendency of vaccination strategy. Video Abstract |
| first_indexed | 2024-04-09T17:46:09Z |
| format | Article |
| id | doaj.art-836736a8b58f4e24a587a4af456dbfa4 |
| institution | Directory Open Access Journal |
| issn | 1478-811X |
| language | English |
| last_indexed | 2024-04-09T17:46:09Z |
| publishDate | 2023-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Communication and Signaling |
| spelling | doaj.art-836736a8b58f4e24a587a4af456dbfa42023-04-16T11:20:22ZengBMCCell Communication and Signaling1478-811X2023-04-0121112210.1186/s12964-023-01098-0Recent advances and future challenges of tumor vaccination therapy for recurrent glioblastomaBinghao Zhao0Jiaming Wu1Huanzhang Li2Yuekun Wang3Yaning Wang4Hao Xing5Yu Wang6Wenbin Ma7Departments of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartments of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartments of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartments of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartments of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartments of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartments of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartments of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Glioblastoma (GBM) is the most malignant CNS tumor with a highest incidence rate, and most patients would undergo a recurrence. Recurrent GBM (rGBM) shows an increasing resistance to chemotherapy and radiotherapy, leading to a significantly poorer prognosis and the urgent need for novel treatments. Immunotherapy, a rapidly developing anti-tumor therapy in recent years, has shown its potential value in rGBM. Recent studies on PD-1 immunotherapy and CAR-T therapy have shown some efficacy, but the outcome was not as expected. Tumor vaccination is the oldest approach of immunotherapies, which has returned to the research focus because of the failure of other strategies and subversive understanding of CNS. The isolation effect of blood brain barrier and the immunosuppressive cell infiltration could lead to resistance existing in all phases of the anti-tumor immune response, where novel tumor vaccines have been designed to overcome these problems through new tumor antigenic targets and regulatory of the systematic immune response. In this review, the immunological characteristics of CNS and GBM would be discussed and summarized, as well as the mechanism of each novel tumor vaccine for rGBM. And through the review of completed early-phase studies and ongoing large-scale phase III clinical trials, evaluation could be conducted for potential immune response, biosecurity and initial clinical outcome, which further draw a panorama of this vital research field and provide some deep thoughts for the prospective tendency of vaccination strategy. Video Abstracthttps://doi.org/10.1186/s12964-023-01098-0Tumor vaccineImmunotherapyRecurrent glioblastomaClinical trial |
| spellingShingle | Binghao Zhao Jiaming Wu Huanzhang Li Yuekun Wang Yaning Wang Hao Xing Yu Wang Wenbin Ma Recent advances and future challenges of tumor vaccination therapy for recurrent glioblastoma Cell Communication and Signaling Tumor vaccine Immunotherapy Recurrent glioblastoma Clinical trial |
| title | Recent advances and future challenges of tumor vaccination therapy for recurrent glioblastoma |
| title_full | Recent advances and future challenges of tumor vaccination therapy for recurrent glioblastoma |
| title_fullStr | Recent advances and future challenges of tumor vaccination therapy for recurrent glioblastoma |
| title_full_unstemmed | Recent advances and future challenges of tumor vaccination therapy for recurrent glioblastoma |
| title_short | Recent advances and future challenges of tumor vaccination therapy for recurrent glioblastoma |
| title_sort | recent advances and future challenges of tumor vaccination therapy for recurrent glioblastoma |
| topic | Tumor vaccine Immunotherapy Recurrent glioblastoma Clinical trial |
| url | https://doi.org/10.1186/s12964-023-01098-0 |
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