Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer
Inositol hexakisphosphate (IP6) is a known assembly cofactor for HIV-1. Here, the authors show the role of IP6 in the assembly of the Rous sarcoma virus (RSV). Reported cryo-ET structures of mature capsid-like particles (CLPs) suggest that IP6 modulates the formation of capsid polyhedrons of variabl...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-05-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23506-0 |
| _version_ | 1818570844445605888 |
|---|---|
| author | Martin Obr Clifton L. Ricana Nadia Nikulin Jon-Philip R. Feathers Marco Klanschnig Andreas Thader Marc C. Johnson Volker M. Vogt Florian K. M. Schur Robert A. Dick |
| author_facet | Martin Obr Clifton L. Ricana Nadia Nikulin Jon-Philip R. Feathers Marco Klanschnig Andreas Thader Marc C. Johnson Volker M. Vogt Florian K. M. Schur Robert A. Dick |
| author_sort | Martin Obr |
| collection | DOAJ |
| description | Inositol hexakisphosphate (IP6) is a known assembly cofactor for HIV-1. Here, the authors show the role of IP6 in the assembly of the Rous sarcoma virus (RSV). Reported cryo-ET structures of mature capsid-like particles (CLPs) suggest that IP6 modulates the formation of capsid polyhedrons of variable shape. |
| first_indexed | 2024-12-14T13:47:13Z |
| format | Article |
| id | doaj.art-8367c143cb65471aa8e3f6f874525a62 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:47:13Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8367c143cb65471aa8e3f6f874525a622022-12-21T22:59:16ZengNature PortfolioNature Communications2041-17232021-05-0112111210.1038/s41467-021-23506-0Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamerMartin Obr0Clifton L. Ricana1Nadia Nikulin2Jon-Philip R. Feathers3Marco Klanschnig4Andreas Thader5Marc C. Johnson6Volker M. Vogt7Florian K. M. Schur8Robert A. Dick9Institute of Science and Technology (IST) AustriaDepartment of Molecular Microbiology and Immunology, University of MissouriDepartment of Molecular Biology and Genetics, Cornell UniversityDepartment of Molecular Biology and Genetics, Cornell UniversityInstitute of Science and Technology (IST) AustriaInstitute of Science and Technology (IST) AustriaDepartment of Molecular Microbiology and Immunology, University of MissouriDepartment of Molecular Biology and Genetics, Cornell UniversityInstitute of Science and Technology (IST) AustriaDepartment of Molecular Biology and Genetics, Cornell UniversityInositol hexakisphosphate (IP6) is a known assembly cofactor for HIV-1. Here, the authors show the role of IP6 in the assembly of the Rous sarcoma virus (RSV). Reported cryo-ET structures of mature capsid-like particles (CLPs) suggest that IP6 modulates the formation of capsid polyhedrons of variable shape.https://doi.org/10.1038/s41467-021-23506-0 |
| spellingShingle | Martin Obr Clifton L. Ricana Nadia Nikulin Jon-Philip R. Feathers Marco Klanschnig Andreas Thader Marc C. Johnson Volker M. Vogt Florian K. M. Schur Robert A. Dick Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer Nature Communications |
| title | Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer |
| title_full | Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer |
| title_fullStr | Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer |
| title_full_unstemmed | Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer |
| title_short | Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer |
| title_sort | structure of the mature rous sarcoma virus lattice reveals a role for ip6 in the formation of the capsid hexamer |
| url | https://doi.org/10.1038/s41467-021-23506-0 |
| work_keys_str_mv | AT martinobr structureofthematureroussarcomaviruslatticerevealsaroleforip6intheformationofthecapsidhexamer AT cliftonlricana structureofthematureroussarcomaviruslatticerevealsaroleforip6intheformationofthecapsidhexamer AT nadianikulin structureofthematureroussarcomaviruslatticerevealsaroleforip6intheformationofthecapsidhexamer AT jonphiliprfeathers structureofthematureroussarcomaviruslatticerevealsaroleforip6intheformationofthecapsidhexamer AT marcoklanschnig structureofthematureroussarcomaviruslatticerevealsaroleforip6intheformationofthecapsidhexamer AT andreasthader structureofthematureroussarcomaviruslatticerevealsaroleforip6intheformationofthecapsidhexamer AT marccjohnson structureofthematureroussarcomaviruslatticerevealsaroleforip6intheformationofthecapsidhexamer AT volkermvogt structureofthematureroussarcomaviruslatticerevealsaroleforip6intheformationofthecapsidhexamer AT floriankmschur structureofthematureroussarcomaviruslatticerevealsaroleforip6intheformationofthecapsidhexamer AT robertadick structureofthematureroussarcomaviruslatticerevealsaroleforip6intheformationofthecapsidhexamer |