A Sandwich Nanostructure of Gold Nanoparticle Coated Reduced Graphene Oxide for Photoacoustic Imaging-Guided Photothermal Therapy in the Second NIR Window
We explore a sandwich-type gold nanoparticle coated reduced graphene oxide (rGO-AuNP) as an effective nanotheranostic platform for the second near-infrared (NIR-II) window photoacoustic (PA) imaging-guided photothermal therapy (PTT) in ovarian cancer. The PEG was loaded onto the AuNPs surface to inc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fbioe.2020.00655/full |
| _version_ | 1828929502712954880 |
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| author | Zhihua Wang Zhihua Wang Zhihua Wang Xiao Sun Xiao Sun Xiao Sun Ting Huang Ting Huang Ting Huang Jibin Song Yudong Wang Yudong Wang Yudong Wang |
| author_facet | Zhihua Wang Zhihua Wang Zhihua Wang Xiao Sun Xiao Sun Xiao Sun Ting Huang Ting Huang Ting Huang Jibin Song Yudong Wang Yudong Wang Yudong Wang |
| author_sort | Zhihua Wang |
| collection | DOAJ |
| description | We explore a sandwich-type gold nanoparticle coated reduced graphene oxide (rGO-AuNP) as an effective nanotheranostic platform for the second near-infrared (NIR-II) window photoacoustic (PA) imaging-guided photothermal therapy (PTT) in ovarian cancer. The PEG was loaded onto the AuNPs surface to increase the stability of nanostructure. The forming rGO-AuNPs- PEG revealed very strong SERS signal, NIR-II PA signal and high photothermal efficiency against tumor upon 1,061 nm laser irradiation. The prominent performance was attributed to the plasmonic coupling of AuNPs, and the enhanced response of rGO and the plasmonic AuNP. Thus, our study demonstrates that the rGO-AuNP nanocomposite could promise to be a potential photothermal agent and pave the way for the diagnosis and therapy of ovarian cancer in the future. |
| first_indexed | 2024-12-14T00:19:52Z |
| format | Article |
| id | doaj.art-83690d23988246189f511504037784fe |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-14T00:19:52Z |
| publishDate | 2020-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-83690d23988246189f511504037784fe2022-12-21T23:25:17ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852020-06-01810.3389/fbioe.2020.00655560769A Sandwich Nanostructure of Gold Nanoparticle Coated Reduced Graphene Oxide for Photoacoustic Imaging-Guided Photothermal Therapy in the Second NIR WindowZhihua Wang0Zhihua Wang1Zhihua Wang2Xiao Sun3Xiao Sun4Xiao Sun5Ting Huang6Ting Huang7Ting Huang8Jibin Song9Yudong Wang10Yudong Wang11Yudong Wang12Department of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Municipal Key Clinical Specialty, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Disease, Shanghai, ChinaDepartment of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Municipal Key Clinical Specialty, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Disease, Shanghai, ChinaDepartment of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Municipal Key Clinical Specialty, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Disease, Shanghai, ChinaMOE Key Laboratory for Analytical Science of Food Safety and Biology College of Chemistry, Fuzhou University, Fuzhou, ChinaDepartment of Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Municipal Key Clinical Specialty, Shanghai, ChinaShanghai Key Laboratory of Embryo Original Disease, Shanghai, ChinaWe explore a sandwich-type gold nanoparticle coated reduced graphene oxide (rGO-AuNP) as an effective nanotheranostic platform for the second near-infrared (NIR-II) window photoacoustic (PA) imaging-guided photothermal therapy (PTT) in ovarian cancer. The PEG was loaded onto the AuNPs surface to increase the stability of nanostructure. The forming rGO-AuNPs- PEG revealed very strong SERS signal, NIR-II PA signal and high photothermal efficiency against tumor upon 1,061 nm laser irradiation. The prominent performance was attributed to the plasmonic coupling of AuNPs, and the enhanced response of rGO and the plasmonic AuNP. Thus, our study demonstrates that the rGO-AuNP nanocomposite could promise to be a potential photothermal agent and pave the way for the diagnosis and therapy of ovarian cancer in the future.https://www.frontiersin.org/article/10.3389/fbioe.2020.00655/fullgold nanoparticlereduced graphene oxidephotoacoustic imagingthe second near-infrared windowphotothermal therapyovarian cancer |
| spellingShingle | Zhihua Wang Zhihua Wang Zhihua Wang Xiao Sun Xiao Sun Xiao Sun Ting Huang Ting Huang Ting Huang Jibin Song Yudong Wang Yudong Wang Yudong Wang A Sandwich Nanostructure of Gold Nanoparticle Coated Reduced Graphene Oxide for Photoacoustic Imaging-Guided Photothermal Therapy in the Second NIR Window Frontiers in Bioengineering and Biotechnology gold nanoparticle reduced graphene oxide photoacoustic imaging the second near-infrared window photothermal therapy ovarian cancer |
| title | A Sandwich Nanostructure of Gold Nanoparticle Coated Reduced Graphene Oxide for Photoacoustic Imaging-Guided Photothermal Therapy in the Second NIR Window |
| title_full | A Sandwich Nanostructure of Gold Nanoparticle Coated Reduced Graphene Oxide for Photoacoustic Imaging-Guided Photothermal Therapy in the Second NIR Window |
| title_fullStr | A Sandwich Nanostructure of Gold Nanoparticle Coated Reduced Graphene Oxide for Photoacoustic Imaging-Guided Photothermal Therapy in the Second NIR Window |
| title_full_unstemmed | A Sandwich Nanostructure of Gold Nanoparticle Coated Reduced Graphene Oxide for Photoacoustic Imaging-Guided Photothermal Therapy in the Second NIR Window |
| title_short | A Sandwich Nanostructure of Gold Nanoparticle Coated Reduced Graphene Oxide for Photoacoustic Imaging-Guided Photothermal Therapy in the Second NIR Window |
| title_sort | sandwich nanostructure of gold nanoparticle coated reduced graphene oxide for photoacoustic imaging guided photothermal therapy in the second nir window |
| topic | gold nanoparticle reduced graphene oxide photoacoustic imaging the second near-infrared window photothermal therapy ovarian cancer |
| url | https://www.frontiersin.org/article/10.3389/fbioe.2020.00655/full |
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