Actionable loss of SLF2 drives B‐cell lymphomagenesis and impairs the DNA damage response

Actionable loss of SLF2 drives B‐cell lymphomagenesis and impairs the DNA damage response

Abstract The DNA damage response (DDR) acts as a barrier to malignant transformation and is often impaired during tumorigenesis. Exploiting the impaired DDR can be a promising therapeutic strategy; however, the mechanisms of inactivation and corresponding biomarkers are incompletely understood. Star...

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Bibliographic Details
Main Authors: Le Zhang, Matthias Wirth, Upayan Patra, Jacob Stroh, Konstandina Isaakidis, Leonie Rieger, Susanne Kossatz, Maja Milanovic, Chuanbing Zang, Uta Demel, Jan Keiten‐Schmitz, Kristina Wagner, Katja Steiger, Roland Rad, Florian Bassermann, Stefan Müller, Ulrich Keller, Markus Schick
Format: Article
Language:English
Published: Springer Nature 2023-09-01
Series:EMBO Molecular Medicine
Subjects:
CHK1
DNA damage response
lymphoma
SLF2
SUMO
Online Access:https://doi.org/10.15252/emmm.202216431

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