SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages
Toll-like receptors engage TIR domain-containing adaptors to control proinflammatory gene expression in response to pathogens and tissue damage. Here the authors show that the non-TIR domain-containing transmembrane protein SCIMP is a previously unrecognized TLR adaptor expressed by macrophages.
Bibliographic Details
| Main Authors: |
Lin Luo,
Nilesh J. Bokil,
Adam A. Wall,
Ronan Kapetanovic,
Natalie M. Lansdaal,
Faustine Marceline,
Belinda J. Burgess,
Samuel J. Tong,
Zhong Guo,
Kirill Alexandrov,
Ian L. Ross,
Margaret L. Hibbs,
Jennifer L. Stow,
Matthew J. Sweet |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2017-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms14133
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