Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects
Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis. Hyperglycemia leads to many serious complications, but also directly initiates the process of β cell apoptosis. A potential strategy for the preservation of pancreatic β cells in diabetes may be to inhibit the impleme...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/2/636 |
| _version_ | 1797493449483616256 |
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| author | Agnieszka Kilanowska Agnieszka Ziółkowska |
| author_facet | Agnieszka Kilanowska Agnieszka Ziółkowska |
| author_sort | Agnieszka Kilanowska |
| collection | DOAJ |
| description | Diabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis. Hyperglycemia leads to many serious complications, but also directly initiates the process of β cell apoptosis. A potential strategy for the preservation of pancreatic β cells in diabetes may be to inhibit the implementation of pro-apoptotic pathways or to enhance the action of pancreatic protective factors. The Hippo signaling pathway is proposed and selected as a target to manipulate the activity of its core proteins in therapy-basic research. MST1 and LATS2, as major upstream signaling kinases of the Hippo pathway, are considered as target candidates for pharmacologically induced tissue regeneration and inhibition of apoptosis. Manipulating the activity of components of the Hippo pathway offers a wide range of possibilities, and thus is a potential tool in the treatment of diabetes and the regeneration of β cells. Therefore, it is important to fully understand the processes involved in apoptosis in diabetic states and completely characterize the role of this pathway in diabetes. Therapy consisting of slowing down or stopping the mechanisms of apoptosis may be an important direction of diabetes treatment in the future. |
| first_indexed | 2024-03-10T01:20:08Z |
| format | Article |
| id | doaj.art-836c1564d49b4f4c947038547fa86c11 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:20:08Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-836c1564d49b4f4c947038547fa86c112023-11-23T14:01:41ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-01-0123263610.3390/ijms23020636Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway ProspectsAgnieszka Kilanowska0Agnieszka Ziółkowska1Department of Anatomy and Histology, Collegium Medicum, University of Zielona Gora, Zyty 28, 65-001 Zielona Gora, PolandDepartment of Anatomy and Histology, Collegium Medicum, University of Zielona Gora, Zyty 28, 65-001 Zielona Gora, PolandDiabetes mellitus is a heterogeneous disease of complex etiology and pathogenesis. Hyperglycemia leads to many serious complications, but also directly initiates the process of β cell apoptosis. A potential strategy for the preservation of pancreatic β cells in diabetes may be to inhibit the implementation of pro-apoptotic pathways or to enhance the action of pancreatic protective factors. The Hippo signaling pathway is proposed and selected as a target to manipulate the activity of its core proteins in therapy-basic research. MST1 and LATS2, as major upstream signaling kinases of the Hippo pathway, are considered as target candidates for pharmacologically induced tissue regeneration and inhibition of apoptosis. Manipulating the activity of components of the Hippo pathway offers a wide range of possibilities, and thus is a potential tool in the treatment of diabetes and the regeneration of β cells. Therefore, it is important to fully understand the processes involved in apoptosis in diabetic states and completely characterize the role of this pathway in diabetes. Therapy consisting of slowing down or stopping the mechanisms of apoptosis may be an important direction of diabetes treatment in the future.https://www.mdpi.com/1422-0067/23/2/636type 2 diabatesHippo pathwayMSTLATSYAPapoptosis |
| spellingShingle | Agnieszka Kilanowska Agnieszka Ziółkowska Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects International Journal of Molecular Sciences type 2 diabates Hippo pathway MST LATS YAP apoptosis |
| title | Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects |
| title_full | Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects |
| title_fullStr | Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects |
| title_full_unstemmed | Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects |
| title_short | Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects |
| title_sort | apoptosis in type 2 diabetes can it be prevented hippo pathway prospects |
| topic | type 2 diabates Hippo pathway MST LATS YAP apoptosis |
| url | https://www.mdpi.com/1422-0067/23/2/636 |
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