Risk factors and drugs that trigger the onset of Stevens–Johnson syndrome and toxic epidermal necrolysis: A population-based cohort study using the Shizuoka Kokuho databaseCapsule Summary
Background: Evidence of factors associated with Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) from population-based studies is scarce. Objective: We aimed to identify the incidence, risk factors, and drugs that trigger the development of SJS/TEN in the general population. Metho...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | JAAD International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666328722001596 |
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| author | Nanako Ubukata, MS Eiji Nakatani, PhD Hideo Hashizume, MD, PhD Hatoko Sasaki, Dr PH Yoshiki Miyachi, MD, PhD |
| author_facet | Nanako Ubukata, MS Eiji Nakatani, PhD Hideo Hashizume, MD, PhD Hatoko Sasaki, Dr PH Yoshiki Miyachi, MD, PhD |
| author_sort | Nanako Ubukata, MS |
| collection | DOAJ |
| description | Background: Evidence of factors associated with Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) from population-based studies is scarce. Objective: We aimed to identify the incidence, risk factors, and drugs that trigger the development of SJS/TEN in the general population. Methods: A regional, population-based, longitudinal cohort with 2,398,393 Japanese individuals was analyzed using the Shizuoka Kokuho Database from 2012 to 2020. Results: Among 1,909,570 individuals, 223 (0.01%, 2.3 cases/100,000 person-years) patients were diagnosed with SJS/TEN during the observational period of a maximum of 7.5 years. In a multivariable analysis, the risks of SJS/TEN were an older age, and the presence of type 2 diabetes, peripheral vascular disease, and systemic autoimmune diseases. The administration of drugs, such as immune checkpoint inhibitors, insulin, and type 2 diabetes agents, triggered the onset of SJS/TEN. Limitations: The results may apply only to the Japanese population. Conclusion: In this cohort population from a database representing the general population, the risks of developing SJS/TEN were old age and a history of type 2 diabetes, peripheral vascular disease, and systemic autoimmune disease. Furthermore, in addition to previously reported drugs, the administration of immune checkpoint inhibitors, insulin, and type 2 diabetes agents, may trigger the development of SJS/TEN. |
| first_indexed | 2024-03-13T10:56:24Z |
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| id | doaj.art-837161a2618946b490c467037e9df7e3 |
| institution | Directory Open Access Journal |
| issn | 2666-3287 |
| language | English |
| last_indexed | 2024-03-13T10:56:24Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JAAD International |
| spelling | doaj.art-837161a2618946b490c467037e9df7e32023-05-17T04:23:20ZengElsevierJAAD International2666-32872023-06-01112432Risk factors and drugs that trigger the onset of Stevens–Johnson syndrome and toxic epidermal necrolysis: A population-based cohort study using the Shizuoka Kokuho databaseCapsule SummaryNanako Ubukata, MS0Eiji Nakatani, PhD1Hideo Hashizume, MD, PhD2Hatoko Sasaki, Dr PH3Yoshiki Miyachi, MD, PhD4Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka-shi, Shizuoka, JapanGraduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka-shi, Shizuoka, JapanGraduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka-shi, Shizuoka, Japan; Department of Dermatology, Iwata City Hospital, Iwata, Japan; Correspondence to: Hideo Hashizume, MD, PhD, Department of Dermatology, Iwata City Hospital, 512-3, Ohkubo, Iwata, Shizuoka, 438–8550, Japan.Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka-shi, Shizuoka, JapanGraduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka-shi, Shizuoka, JapanBackground: Evidence of factors associated with Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) from population-based studies is scarce. Objective: We aimed to identify the incidence, risk factors, and drugs that trigger the development of SJS/TEN in the general population. Methods: A regional, population-based, longitudinal cohort with 2,398,393 Japanese individuals was analyzed using the Shizuoka Kokuho Database from 2012 to 2020. Results: Among 1,909,570 individuals, 223 (0.01%, 2.3 cases/100,000 person-years) patients were diagnosed with SJS/TEN during the observational period of a maximum of 7.5 years. In a multivariable analysis, the risks of SJS/TEN were an older age, and the presence of type 2 diabetes, peripheral vascular disease, and systemic autoimmune diseases. The administration of drugs, such as immune checkpoint inhibitors, insulin, and type 2 diabetes agents, triggered the onset of SJS/TEN. Limitations: The results may apply only to the Japanese population. Conclusion: In this cohort population from a database representing the general population, the risks of developing SJS/TEN were old age and a history of type 2 diabetes, peripheral vascular disease, and systemic autoimmune disease. Furthermore, in addition to previously reported drugs, the administration of immune checkpoint inhibitors, insulin, and type 2 diabetes agents, may trigger the development of SJS/TEN.http://www.sciencedirect.com/science/article/pii/S2666328722001596claims databasedrug eruptionpopulation-based cohort studypharmacoepidemiologyrisk factorsafety |
| spellingShingle | Nanako Ubukata, MS Eiji Nakatani, PhD Hideo Hashizume, MD, PhD Hatoko Sasaki, Dr PH Yoshiki Miyachi, MD, PhD Risk factors and drugs that trigger the onset of Stevens–Johnson syndrome and toxic epidermal necrolysis: A population-based cohort study using the Shizuoka Kokuho databaseCapsule Summary JAAD International claims database drug eruption population-based cohort study pharmacoepidemiology risk factor safety |
| title | Risk factors and drugs that trigger the onset of Stevens–Johnson syndrome and toxic epidermal necrolysis: A population-based cohort study using the Shizuoka Kokuho databaseCapsule Summary |
| title_full | Risk factors and drugs that trigger the onset of Stevens–Johnson syndrome and toxic epidermal necrolysis: A population-based cohort study using the Shizuoka Kokuho databaseCapsule Summary |
| title_fullStr | Risk factors and drugs that trigger the onset of Stevens–Johnson syndrome and toxic epidermal necrolysis: A population-based cohort study using the Shizuoka Kokuho databaseCapsule Summary |
| title_full_unstemmed | Risk factors and drugs that trigger the onset of Stevens–Johnson syndrome and toxic epidermal necrolysis: A population-based cohort study using the Shizuoka Kokuho databaseCapsule Summary |
| title_short | Risk factors and drugs that trigger the onset of Stevens–Johnson syndrome and toxic epidermal necrolysis: A population-based cohort study using the Shizuoka Kokuho databaseCapsule Summary |
| title_sort | risk factors and drugs that trigger the onset of stevens johnson syndrome and toxic epidermal necrolysis a population based cohort study using the shizuoka kokuho databasecapsule summary |
| topic | claims database drug eruption population-based cohort study pharmacoepidemiology risk factor safety |
| url | http://www.sciencedirect.com/science/article/pii/S2666328722001596 |
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