Relationship of fasting glucose and longitudinal Alzheimer's disease imaging markers
Abstract Introduction Fasting glucose increases with age and is linked to modifiable Alzheimer's disease risk factors such as cardiovascular disease and Type 2 diabetes (T2D). Methods We leveraged available biospecimens and neuroimaging measures collected during the Alzheimer's Prevention...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12239 |
| _version_ | 1797948994901508096 |
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| author | Robyn A. Honea Casey S. John Zachary D. Green Paul J. Kueck Matthew K. Taylor Rebecca J. Lepping Ryan Townley Eric D. Vidoni Jeffery M. Burns Jill K. Morris |
| author_facet | Robyn A. Honea Casey S. John Zachary D. Green Paul J. Kueck Matthew K. Taylor Rebecca J. Lepping Ryan Townley Eric D. Vidoni Jeffery M. Burns Jill K. Morris |
| author_sort | Robyn A. Honea |
| collection | DOAJ |
| description | Abstract Introduction Fasting glucose increases with age and is linked to modifiable Alzheimer's disease risk factors such as cardiovascular disease and Type 2 diabetes (T2D). Methods We leveraged available biospecimens and neuroimaging measures collected during the Alzheimer's Prevention Through Exercise (APEx) trial (n = 105) to examine the longitudinal relationship between change in blood glucose metabolism and change in regional cerebral amyloid deposition and gray and white matter (WM) neurodegeneration in older adults over 1 year of follow‐up. Results Individuals with improving fasting glucose (n = 61) exhibited less atrophy and regional amyloid accumulation compared to those whose fasting glucose worsened over 1 year (n = 44). Specifically, while individuals with increasing fasting glucose did not yet show cognitive decline, they did have regional atrophy in the hippocampus and inferior parietal cortex, and increased amyloid accumulation in the precuneus cortex. Signs of early dementia pathology occurred in the absence of significant group differences in insulin or body composition, and was not modified by apolipoprotein E ε4 carrier status. Discussion Dysregulation of glucose in late life may signal preclinical brain change prior to clinically relevant cognitive decline. Additional work is needed to determine whether treatments specifically targeting fasting glucose levels may impact change in brain structure or cerebral amyloid in older adults. |
| first_indexed | 2024-04-10T21:53:29Z |
| format | Article |
| id | doaj.art-837417a03d1c498db258d6d94f005cde |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-04-10T21:53:29Z |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-837417a03d1c498db258d6d94f005cde2023-01-18T11:41:03ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372022-01-0181n/an/a10.1002/trc2.12239Relationship of fasting glucose and longitudinal Alzheimer's disease imaging markersRobyn A. Honea0Casey S. John1Zachary D. Green2Paul J. Kueck3Matthew K. Taylor4Rebecca J. Lepping5Ryan Townley6Eric D. Vidoni7Jeffery M. Burns8Jill K. Morris9University of Kansas Alzheimer's Disease Research Center Kansas City Kansas USAUniversity of Kansas Alzheimer's Disease Research Center Kansas City Kansas USAUniversity of Kansas Alzheimer's Disease Research Center Kansas City Kansas USAUniversity of Kansas Alzheimer's Disease Research Center Kansas City Kansas USADepartment of Dietetics and Nutrition University of Kansas Medical Center Kansas City Kansas USAHoglund Biomedical Imaging Center University of Kansas Medical Center Kansas City Kansas USAUniversity of Kansas Alzheimer's Disease Research Center Kansas City Kansas USAUniversity of Kansas Alzheimer's Disease Research Center Kansas City Kansas USAUniversity of Kansas Alzheimer's Disease Research Center Kansas City Kansas USAUniversity of Kansas Alzheimer's Disease Research Center Kansas City Kansas USAAbstract Introduction Fasting glucose increases with age and is linked to modifiable Alzheimer's disease risk factors such as cardiovascular disease and Type 2 diabetes (T2D). Methods We leveraged available biospecimens and neuroimaging measures collected during the Alzheimer's Prevention Through Exercise (APEx) trial (n = 105) to examine the longitudinal relationship between change in blood glucose metabolism and change in regional cerebral amyloid deposition and gray and white matter (WM) neurodegeneration in older adults over 1 year of follow‐up. Results Individuals with improving fasting glucose (n = 61) exhibited less atrophy and regional amyloid accumulation compared to those whose fasting glucose worsened over 1 year (n = 44). Specifically, while individuals with increasing fasting glucose did not yet show cognitive decline, they did have regional atrophy in the hippocampus and inferior parietal cortex, and increased amyloid accumulation in the precuneus cortex. Signs of early dementia pathology occurred in the absence of significant group differences in insulin or body composition, and was not modified by apolipoprotein E ε4 carrier status. Discussion Dysregulation of glucose in late life may signal preclinical brain change prior to clinically relevant cognitive decline. Additional work is needed to determine whether treatments specifically targeting fasting glucose levels may impact change in brain structure or cerebral amyloid in older adults.https://doi.org/10.1002/trc2.12239Alzheimer's diseaseamyloidglucosehippocampusimagingmetabolism |
| spellingShingle | Robyn A. Honea Casey S. John Zachary D. Green Paul J. Kueck Matthew K. Taylor Rebecca J. Lepping Ryan Townley Eric D. Vidoni Jeffery M. Burns Jill K. Morris Relationship of fasting glucose and longitudinal Alzheimer's disease imaging markers Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's disease amyloid glucose hippocampus imaging metabolism |
| title | Relationship of fasting glucose and longitudinal Alzheimer's disease imaging markers |
| title_full | Relationship of fasting glucose and longitudinal Alzheimer's disease imaging markers |
| title_fullStr | Relationship of fasting glucose and longitudinal Alzheimer's disease imaging markers |
| title_full_unstemmed | Relationship of fasting glucose and longitudinal Alzheimer's disease imaging markers |
| title_short | Relationship of fasting glucose and longitudinal Alzheimer's disease imaging markers |
| title_sort | relationship of fasting glucose and longitudinal alzheimer s disease imaging markers |
| topic | Alzheimer's disease amyloid glucose hippocampus imaging metabolism |
| url | https://doi.org/10.1002/trc2.12239 |
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