Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation, Characterization and Drug Nanoencapsulation
Unimolecular polymeric micelles are a class of single-molecule amphiphilic core-shell polymeric architectures, where the hydrophobic core is well stabilized by the hydrophilic shell, avoiding intermolecular core-core interactions. Multi-arm copolymers with a dendritic core, as well as hyperbranched...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-11-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/10/4/209 |
| _version_ | 1798040334764081152 |
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| author | Stefania Ordanini Francesco Cellesi |
| author_facet | Stefania Ordanini Francesco Cellesi |
| author_sort | Stefania Ordanini |
| collection | DOAJ |
| description | Unimolecular polymeric micelles are a class of single-molecule amphiphilic core-shell polymeric architectures, where the hydrophobic core is well stabilized by the hydrophilic shell, avoiding intermolecular core-core interactions. Multi-arm copolymers with a dendritic core, as well as hyperbranched and comb-like polymers, can form unimolecular micelles easily. In this review, examples of polymers able to form detectable unimolecular micelles will be presented, summarizing the analytical techniques used to characterize the unimolecular micelles and discriminate them from other supramolecular aggregates, such as multi-micelle aggregates. Unimolecular micelles are suitable for the nanoencapsulation of guest molecules. Compared to traditional supramolecular micelles, unimolecular micelles do not disassemble under dilution and are stable to environmental modifications. Recent examples of their application as drug delivery systems, endowed with increased stability and transport properties, will be discussed. |
| first_indexed | 2024-04-11T22:06:11Z |
| format | Article |
| id | doaj.art-83742d1bd9404c50b69e3e0527e148ea |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T22:06:11Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-83742d1bd9404c50b69e3e0527e148ea2022-12-22T04:00:43ZengMDPI AGPharmaceutics1999-49232018-11-0110420910.3390/pharmaceutics10040209pharmaceutics10040209Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation, Characterization and Drug NanoencapsulationStefania Ordanini0Francesco Cellesi1Dipartimento di Chimica, Materiali ed Ingegneria Chimica “G. Natta”, Politecnico di Milano, Via Mancinelli 7, 20131 Milan, ItalyDipartimento di Chimica, Materiali ed Ingegneria Chimica “G. Natta”, Politecnico di Milano, Via Mancinelli 7, 20131 Milan, ItalyUnimolecular polymeric micelles are a class of single-molecule amphiphilic core-shell polymeric architectures, where the hydrophobic core is well stabilized by the hydrophilic shell, avoiding intermolecular core-core interactions. Multi-arm copolymers with a dendritic core, as well as hyperbranched and comb-like polymers, can form unimolecular micelles easily. In this review, examples of polymers able to form detectable unimolecular micelles will be presented, summarizing the analytical techniques used to characterize the unimolecular micelles and discriminate them from other supramolecular aggregates, such as multi-micelle aggregates. Unimolecular micelles are suitable for the nanoencapsulation of guest molecules. Compared to traditional supramolecular micelles, unimolecular micelles do not disassemble under dilution and are stable to environmental modifications. Recent examples of their application as drug delivery systems, endowed with increased stability and transport properties, will be discussed.https://www.mdpi.com/1999-4923/10/4/209complex polymeric architecturesunimolecular micellesunimolecular micelles characterizationdrug deliverynanoencapsulation |
| spellingShingle | Stefania Ordanini Francesco Cellesi Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation, Characterization and Drug Nanoencapsulation Pharmaceutics complex polymeric architectures unimolecular micelles unimolecular micelles characterization drug delivery nanoencapsulation |
| title | Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation, Characterization and Drug Nanoencapsulation |
| title_full | Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation, Characterization and Drug Nanoencapsulation |
| title_fullStr | Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation, Characterization and Drug Nanoencapsulation |
| title_full_unstemmed | Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation, Characterization and Drug Nanoencapsulation |
| title_short | Complex Polymeric Architectures Self-Assembling in Unimolecular Micelles: Preparation, Characterization and Drug Nanoencapsulation |
| title_sort | complex polymeric architectures self assembling in unimolecular micelles preparation characterization and drug nanoencapsulation |
| topic | complex polymeric architectures unimolecular micelles unimolecular micelles characterization drug delivery nanoencapsulation |
| url | https://www.mdpi.com/1999-4923/10/4/209 |
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