Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms
The existence of orderly structures, such as tissues and organs is made possible by cell adhesion, i.e., the process by which cells attach to neighbouring cells and a supporting substance in the form of the extracellular matrix. The extracellular matrix is a three-dimensional structure composed of c...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/5/914 |
| _version_ | 1797475344812343296 |
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| author | Aleksandra Bandzerewicz Agnieszka Gadomska-Gajadhur |
| author_facet | Aleksandra Bandzerewicz Agnieszka Gadomska-Gajadhur |
| author_sort | Aleksandra Bandzerewicz |
| collection | DOAJ |
| description | The existence of orderly structures, such as tissues and organs is made possible by cell adhesion, i.e., the process by which cells attach to neighbouring cells and a supporting substance in the form of the extracellular matrix. The extracellular matrix is a three-dimensional structure composed of collagens, elastin, and various proteoglycans and glycoproteins. It is a storehouse for multiple signalling factors. Cells are informed of their correct connection to the matrix via receptors. Tissue disruption often prevents the natural reconstitution of the matrix. The use of appropriate implants is then required. This review is a compilation of crucial information on the structural and functional features of the extracellular matrix and the complex mechanisms of cell–cell connectivity. The possibilities of regenerating damaged tissues using an artificial matrix substitute are described, detailing the host response to the implant. An important issue is the surface properties of such an implant and the possibilities of their modification. |
| first_indexed | 2024-03-09T20:43:48Z |
| format | Article |
| id | doaj.art-83780c8d25f541b5bb6e8fe2a3a1bfa8 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T20:43:48Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-83780c8d25f541b5bb6e8fe2a3a1bfa82023-11-23T22:52:11ZengMDPI AGCells2073-44092022-03-0111591410.3390/cells11050914Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling MechanismsAleksandra Bandzerewicz0Agnieszka Gadomska-Gajadhur1Faculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, 00-664 Warsaw, PolandFaculty of Chemistry, Warsaw University of Technology, Noakowskiego 3 Street, 00-664 Warsaw, PolandThe existence of orderly structures, such as tissues and organs is made possible by cell adhesion, i.e., the process by which cells attach to neighbouring cells and a supporting substance in the form of the extracellular matrix. The extracellular matrix is a three-dimensional structure composed of collagens, elastin, and various proteoglycans and glycoproteins. It is a storehouse for multiple signalling factors. Cells are informed of their correct connection to the matrix via receptors. Tissue disruption often prevents the natural reconstitution of the matrix. The use of appropriate implants is then required. This review is a compilation of crucial information on the structural and functional features of the extracellular matrix and the complex mechanisms of cell–cell connectivity. The possibilities of regenerating damaged tissues using an artificial matrix substitute are described, detailing the host response to the implant. An important issue is the surface properties of such an implant and the possibilities of their modification.https://www.mdpi.com/2073-4409/11/5/914extracellular matrixcellular receptorscell adhesioncell signallingscaffoldsbiomaterials |
| spellingShingle | Aleksandra Bandzerewicz Agnieszka Gadomska-Gajadhur Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms Cells extracellular matrix cellular receptors cell adhesion cell signalling scaffolds biomaterials |
| title | Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms |
| title_full | Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms |
| title_fullStr | Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms |
| title_full_unstemmed | Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms |
| title_short | Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms |
| title_sort | into the tissues extracellular matrix and its artificial substitutes cell signalling mechanisms |
| topic | extracellular matrix cellular receptors cell adhesion cell signalling scaffolds biomaterials |
| url | https://www.mdpi.com/2073-4409/11/5/914 |
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