Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines
Preventing the spread of multidrug-resistant Gram-negative bacteria (MDRGNB) is a public health priority. However, the definition of MDRGNB applied for planning infection prevention measures such as barrier precautions differs depending on national guidelines. This is particularly relevant in the Du...
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| Format: | Article |
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MDPI AG
2018-01-01
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| Series: | Microorganisms |
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| Online Access: | http://www.mdpi.com/2076-2607/6/1/11 |
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| author | Robin Köck Philipp Siemer Jutta Esser Stefanie Kampmeier Matthijs S. Berends Corinna Glasner Jan P. Arends Karsten Becker Alexander W. Friedrich |
| author_facet | Robin Köck Philipp Siemer Jutta Esser Stefanie Kampmeier Matthijs S. Berends Corinna Glasner Jan P. Arends Karsten Becker Alexander W. Friedrich |
| author_sort | Robin Köck |
| collection | DOAJ |
| description | Preventing the spread of multidrug-resistant Gram-negative bacteria (MDRGNB) is a public health priority. However, the definition of MDRGNB applied for planning infection prevention measures such as barrier precautions differs depending on national guidelines. This is particularly relevant in the Dutch–German border region, where patients are transferred between healthcare facilities located in the two different countries, because clinicians and infection control personnel must understand antibiograms indicating MDRGNB from both sides of the border and using both national guidelines. This retrospective study aimed to compare antibiograms of Gram-negative bacteria and classify them using the Dutch and German national standards for MDRGNB definition. A total of 31,787 antibiograms from six Dutch and four German hospitals were classified. Overall, 73.7% were no MDRGNB according to both guidelines. According to the Dutch and German guideline, 7772/31,787 (24.5%) and 4586/31,787 (12.9%) were MDRGNB, respectively (p < 0.0001). Major divergent classifications were observed for extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae, non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia. The observed differences show that medical staff must carefully check previous diagnostic findings when patients are transferred across the Dutch–German border, as it cannot be assumed that MDRGNB requiring special hygiene precautions are marked in the transferred antibiograms in accordance with both national guidelines. |
| first_indexed | 2024-12-21T13:09:59Z |
| format | Article |
| id | doaj.art-8378448e1a244d62a2b2df89efeda2ca |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-12-21T13:09:59Z |
| publishDate | 2018-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-8378448e1a244d62a2b2df89efeda2ca2022-12-21T19:02:55ZengMDPI AGMicroorganisms2076-26072018-01-01611110.3390/microorganisms6010011microorganisms6010011Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National GuidelinesRobin Köck0Philipp Siemer1Jutta Esser2Stefanie Kampmeier3Matthijs S. Berends4Corinna Glasner5Jan P. Arends6Karsten Becker7Alexander W. Friedrich8Institute of Hospital Hygiene Oldenburg, 26133 Oldenburg, GermanyEuropean Medical School Oldenburg-Groningen, 26129 Oldenburg, GermanyLaborarztpraxis Osnabrück, 49124 Georgsmarienhütte, GermanyInstitute of Hygiene, University Hospital Münster, 48149 Münster, GermanyCerte Medical Diagnostics & Advice, 9700 AX Groningen, The NetherlandsDepartment of Medical Microbiology, University Medical Center Groningen (UMCG), University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Medical Microbiology, University Medical Center Groningen (UMCG), University of Groningen, 9713 GZ Groningen, The NetherlandsInstitute of Medical Microbiology, University Hospital Münster, 48149 Münster, GermanyDepartment of Medical Microbiology, University Medical Center Groningen (UMCG), University of Groningen, 9713 GZ Groningen, The NetherlandsPreventing the spread of multidrug-resistant Gram-negative bacteria (MDRGNB) is a public health priority. However, the definition of MDRGNB applied for planning infection prevention measures such as barrier precautions differs depending on national guidelines. This is particularly relevant in the Dutch–German border region, where patients are transferred between healthcare facilities located in the two different countries, because clinicians and infection control personnel must understand antibiograms indicating MDRGNB from both sides of the border and using both national guidelines. This retrospective study aimed to compare antibiograms of Gram-negative bacteria and classify them using the Dutch and German national standards for MDRGNB definition. A total of 31,787 antibiograms from six Dutch and four German hospitals were classified. Overall, 73.7% were no MDRGNB according to both guidelines. According to the Dutch and German guideline, 7772/31,787 (24.5%) and 4586/31,787 (12.9%) were MDRGNB, respectively (p < 0.0001). Major divergent classifications were observed for extended-spectrum β-lactamase (ESBL) -producing Enterobacteriaceae, non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae, Pseudomonas aeruginosa and Stenotrophomonas maltophilia. The observed differences show that medical staff must carefully check previous diagnostic findings when patients are transferred across the Dutch–German border, as it cannot be assumed that MDRGNB requiring special hygiene precautions are marked in the transferred antibiograms in accordance with both national guidelines.http://www.mdpi.com/2076-2607/6/1/11ESBLcarbapenemaseEuregiomultidrug resistanceKlebsiellaEscherichia coliAcinetobacter baumanniiStenotrophomonas maltophiliaEnterobacteriaceae |
| spellingShingle | Robin Köck Philipp Siemer Jutta Esser Stefanie Kampmeier Matthijs S. Berends Corinna Glasner Jan P. Arends Karsten Becker Alexander W. Friedrich Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines Microorganisms ESBL carbapenemase Euregio multidrug resistance Klebsiella Escherichia coli Acinetobacter baumannii Stenotrophomonas maltophilia Enterobacteriaceae |
| title | Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines |
| title_full | Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines |
| title_fullStr | Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines |
| title_full_unstemmed | Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines |
| title_short | Defining Multidrug Resistance of Gram-Negative Bacteria in the Dutch–German Border Region—Impact of National Guidelines |
| title_sort | defining multidrug resistance of gram negative bacteria in the dutch german border region impact of national guidelines |
| topic | ESBL carbapenemase Euregio multidrug resistance Klebsiella Escherichia coli Acinetobacter baumannii Stenotrophomonas maltophilia Enterobacteriaceae |
| url | http://www.mdpi.com/2076-2607/6/1/11 |
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