Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh.
The association of vitamin D with neuro-behavioral outcomes of young children is unclear, particularly of those who reside in tropical countries and are otherwise exposed to adequate sun light. To investigate this association, we analysed the existing data of poor infants, who participated in an obs...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0221805 |
| _version_ | 1819016610292170752 |
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| author | Fahmida Tofail M Munirul Islam Mustafa Mahfuz Md Ashraful Alam Shirina Aktar Rashidul Haque Md Iqbal Hossain Dinesh Mondal William A Petri Tahmeed Ahmed |
| author_facet | Fahmida Tofail M Munirul Islam Mustafa Mahfuz Md Ashraful Alam Shirina Aktar Rashidul Haque Md Iqbal Hossain Dinesh Mondal William A Petri Tahmeed Ahmed |
| author_sort | Fahmida Tofail |
| collection | DOAJ |
| description | The association of vitamin D with neuro-behavioral outcomes of young children is unclear, particularly of those who reside in tropical countries and are otherwise exposed to adequate sun light. To investigate this association, we analysed the existing data of poor infants, who participated in an observational, prospective-cohort (MalED) study, conducted in a slum of Dhaka-city. We assessed 265 infants aged 6-8 months for cognitive, motor, language and behavior development using Bayley-III. Information about infants' temperament and communicative skills were provided by the mothers through a culturally modified "temperament-scale" and a "communicative-developmental inventory". Serum concentration of vitamin D [25(OH)D] was measured in 205 infants. Around 28.3% of infants in this community had low level vitamin D, with the cut-off at <50 nmol/L. After controlling for all possible covariates, a multivariable-adjusted linear regression showed that children with vitamin D levels <50 nmol/L had significantly lower scores in two dimensions of temperament: activity (B±SE 1.64±0.78; 95%CI 0.10, 3.18; p = 0.037; effect size 0.37 SDs) and soothabilty (2.02±0.70; 0.64, 3.41; p = 0.004; 0.53 SDs), compared to children with vitamin D levels of ≥50nmol/L. These infants also scored low in word comprehensions (1.28±0.62; 0.05, 2.51; p = 0.042; 0.23 SDs) and were less active during test-procedures (0.33±0.16; 0.02, 0.64; p = 0.035; 0.27 SDs). Both the groups tested similarly in cognitive and motor scores. This study found, despite adequate sunlight-exposure, one in four infants of this slum-community are suffering from a subclinical vitamin D deficiency. Higher levels of vitamin D in these infants showed a positive association with temperament, language and behavior but not with cognitive and motor development. Our findings highlight the early-detected extra-skeletal neuro-behavioral role of vitamin D. Future studies in this area will give more insight. |
| first_indexed | 2024-12-21T02:50:22Z |
| format | Article |
| id | doaj.art-837a8aa7549b494f829c769fad70fe27 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T02:50:22Z |
| publishDate | 2019-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-837a8aa7549b494f829c769fad70fe272022-12-21T19:18:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032019-01-01149e022180510.1371/journal.pone.0221805Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh.Fahmida TofailM Munirul IslamMustafa MahfuzMd Ashraful AlamShirina AktarRashidul HaqueMd Iqbal HossainDinesh MondalWilliam A PetriTahmeed AhmedThe association of vitamin D with neuro-behavioral outcomes of young children is unclear, particularly of those who reside in tropical countries and are otherwise exposed to adequate sun light. To investigate this association, we analysed the existing data of poor infants, who participated in an observational, prospective-cohort (MalED) study, conducted in a slum of Dhaka-city. We assessed 265 infants aged 6-8 months for cognitive, motor, language and behavior development using Bayley-III. Information about infants' temperament and communicative skills were provided by the mothers through a culturally modified "temperament-scale" and a "communicative-developmental inventory". Serum concentration of vitamin D [25(OH)D] was measured in 205 infants. Around 28.3% of infants in this community had low level vitamin D, with the cut-off at <50 nmol/L. After controlling for all possible covariates, a multivariable-adjusted linear regression showed that children with vitamin D levels <50 nmol/L had significantly lower scores in two dimensions of temperament: activity (B±SE 1.64±0.78; 95%CI 0.10, 3.18; p = 0.037; effect size 0.37 SDs) and soothabilty (2.02±0.70; 0.64, 3.41; p = 0.004; 0.53 SDs), compared to children with vitamin D levels of ≥50nmol/L. These infants also scored low in word comprehensions (1.28±0.62; 0.05, 2.51; p = 0.042; 0.23 SDs) and were less active during test-procedures (0.33±0.16; 0.02, 0.64; p = 0.035; 0.27 SDs). Both the groups tested similarly in cognitive and motor scores. This study found, despite adequate sunlight-exposure, one in four infants of this slum-community are suffering from a subclinical vitamin D deficiency. Higher levels of vitamin D in these infants showed a positive association with temperament, language and behavior but not with cognitive and motor development. Our findings highlight the early-detected extra-skeletal neuro-behavioral role of vitamin D. Future studies in this area will give more insight.https://doi.org/10.1371/journal.pone.0221805 |
| spellingShingle | Fahmida Tofail M Munirul Islam Mustafa Mahfuz Md Ashraful Alam Shirina Aktar Rashidul Haque Md Iqbal Hossain Dinesh Mondal William A Petri Tahmeed Ahmed Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh. PLoS ONE |
| title | Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh. |
| title_full | Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh. |
| title_fullStr | Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh. |
| title_full_unstemmed | Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh. |
| title_short | Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh. |
| title_sort | association of vitamin d nutrition with neuro developmental outcome of infants of slums in bangladesh |
| url | https://doi.org/10.1371/journal.pone.0221805 |
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