Risk of <i>Pneumocystis jirovecii</i> Pneumonia among Solid Organ Transplant Recipients: A Population-Based Study
Few studies have comprehensively investigated the occurrence of <i>Pneumocystis jirovecii</i> pneumonia (PJP) among solid organ transplant (SOT) recipients. This study investigated the risk of PJP after organ transplantation. Each patient who underwent SOT was propensity-score-matched wi...
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| Format: | Article |
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MDPI AG
2022-12-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/9/1/23 |
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| author | Yih-Dih Cheng Ching-Hua Huang Shuo-Yan Gau Ning-Jen Chung Shiang-Wen Huang Cheng-Yang Huang Chien-Ying Lee |
| author_facet | Yih-Dih Cheng Ching-Hua Huang Shuo-Yan Gau Ning-Jen Chung Shiang-Wen Huang Cheng-Yang Huang Chien-Ying Lee |
| author_sort | Yih-Dih Cheng |
| collection | DOAJ |
| description | Few studies have comprehensively investigated the occurrence of <i>Pneumocystis jirovecii</i> pneumonia (PJP) among solid organ transplant (SOT) recipients. This study investigated the risk of PJP after organ transplantation. Each patient who underwent SOT was propensity-score-matched with four non-SOT individuals in terms of sex, age, insured salary, urbanization of residence, comorbidities, and year of enrollment. When considering the 3-year follow-up, the patients who had undergone SOT were at higher risk of PJP, with the adjusted odds ratio (aOR) being 17.18 (95% confidence interval (CI): 8.80–33.53). Furthermore, SOT recipients were also at higher PJP risk than the patients without SOT at 6 months, 1 year, and 2 years, with the aOR being 22.64 (95% CI: 7.53–68.11), 26.19 (95% CI: 9.89–69.37), and 23.06 (95% CI: 10.23–51.97), respectively. Patients comorbid with HIV infection, hematological malignancies, or vasculitis were at higher risk (aOR = 59.08, 95% CI = 20.30–171.92), (aOR = 11.94, 95% CI = 5.36–26.61), and (aOR = 21.72, 95% CI = 2.41–195.81), respectively. The recipients of SOT were at higher risk of PJP, and PJP can develop at any stage after transplantation. SOT recipients comorbid with HIV, hematologic malignancies, or vasculitis were at higher PJP risk. |
| first_indexed | 2024-03-09T12:04:48Z |
| format | Article |
| id | doaj.art-837aead16bf74f36b142ea96d1291d00 |
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| issn | 2309-608X |
| language | English |
| last_indexed | 2024-03-09T12:04:48Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-837aead16bf74f36b142ea96d1291d002023-11-30T22:59:17ZengMDPI AGJournal of Fungi2309-608X2022-12-01912310.3390/jof9010023Risk of <i>Pneumocystis jirovecii</i> Pneumonia among Solid Organ Transplant Recipients: A Population-Based StudyYih-Dih Cheng0Ching-Hua Huang1Shuo-Yan Gau2Ning-Jen Chung3Shiang-Wen Huang4Cheng-Yang Huang5Chien-Ying Lee6School of Pharmacy, China Medical University, Taichung 40402, TaiwanDepartment of Pharmacology, Chung Shan Medical University, Taichung 40201, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung 40201, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung 40201, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung 40201, TaiwanSchool of Medicine, Chung Shan Medical University, Taichung 40201, TaiwanDepartment of Pharmacology, Chung Shan Medical University, Taichung 40201, TaiwanFew studies have comprehensively investigated the occurrence of <i>Pneumocystis jirovecii</i> pneumonia (PJP) among solid organ transplant (SOT) recipients. This study investigated the risk of PJP after organ transplantation. Each patient who underwent SOT was propensity-score-matched with four non-SOT individuals in terms of sex, age, insured salary, urbanization of residence, comorbidities, and year of enrollment. When considering the 3-year follow-up, the patients who had undergone SOT were at higher risk of PJP, with the adjusted odds ratio (aOR) being 17.18 (95% confidence interval (CI): 8.80–33.53). Furthermore, SOT recipients were also at higher PJP risk than the patients without SOT at 6 months, 1 year, and 2 years, with the aOR being 22.64 (95% CI: 7.53–68.11), 26.19 (95% CI: 9.89–69.37), and 23.06 (95% CI: 10.23–51.97), respectively. Patients comorbid with HIV infection, hematological malignancies, or vasculitis were at higher risk (aOR = 59.08, 95% CI = 20.30–171.92), (aOR = 11.94, 95% CI = 5.36–26.61), and (aOR = 21.72, 95% CI = 2.41–195.81), respectively. The recipients of SOT were at higher risk of PJP, and PJP can develop at any stage after transplantation. SOT recipients comorbid with HIV, hematologic malignancies, or vasculitis were at higher PJP risk.https://www.mdpi.com/2309-608X/9/1/23<i>Pneumocystis jirovecii</i> pneumoniasolid organ transplantadjusted odds ratio |
| spellingShingle | Yih-Dih Cheng Ching-Hua Huang Shuo-Yan Gau Ning-Jen Chung Shiang-Wen Huang Cheng-Yang Huang Chien-Ying Lee Risk of <i>Pneumocystis jirovecii</i> Pneumonia among Solid Organ Transplant Recipients: A Population-Based Study Journal of Fungi <i>Pneumocystis jirovecii</i> pneumonia solid organ transplant adjusted odds ratio |
| title | Risk of <i>Pneumocystis jirovecii</i> Pneumonia among Solid Organ Transplant Recipients: A Population-Based Study |
| title_full | Risk of <i>Pneumocystis jirovecii</i> Pneumonia among Solid Organ Transplant Recipients: A Population-Based Study |
| title_fullStr | Risk of <i>Pneumocystis jirovecii</i> Pneumonia among Solid Organ Transplant Recipients: A Population-Based Study |
| title_full_unstemmed | Risk of <i>Pneumocystis jirovecii</i> Pneumonia among Solid Organ Transplant Recipients: A Population-Based Study |
| title_short | Risk of <i>Pneumocystis jirovecii</i> Pneumonia among Solid Organ Transplant Recipients: A Population-Based Study |
| title_sort | risk of i pneumocystis jirovecii i pneumonia among solid organ transplant recipients a population based study |
| topic | <i>Pneumocystis jirovecii</i> pneumonia solid organ transplant adjusted odds ratio |
| url | https://www.mdpi.com/2309-608X/9/1/23 |
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