Circulating mid-regional proadrenomedullin is a predictor of mortality in patients with COVID-19: a systematic review and meta-analysis
Abstract Background Although there is increasing understanding of the changes in the laboratory parameters of Coronavirus disease 2019 (COVID-19), the correlation between circulating Mid-regional Proadrenomedullin (MR-proADM) and mortality of patients with COVID-19 is not fully understood. In this s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-023-08275-z |
| _version_ | 1827948276669743104 |
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| author | Na Wang Lushan Liu Wei He Na Shang Junyu Li Zhou Qin Xiaoxia Du |
| author_facet | Na Wang Lushan Liu Wei He Na Shang Junyu Li Zhou Qin Xiaoxia Du |
| author_sort | Na Wang |
| collection | DOAJ |
| description | Abstract Background Although there is increasing understanding of the changes in the laboratory parameters of Coronavirus disease 2019 (COVID-19), the correlation between circulating Mid-regional Proadrenomedullin (MR-proADM) and mortality of patients with COVID-19 is not fully understood. In this study, we conducted a systematic review and meta-analysis to evaluate the prognostic value of MR-proADM in patients with COVID-19. Methods The PubMed, Embase, Web of Science, Cochrane Library, Wanfang, SinoMed and Chinese National Knowledge Infrastructure (CNKI) databases were searched from 1 January 2020 to 20 March 2022 for relevant literature. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) was used to assess quality bias, STATA was employed to pool the effect size by a random effects model, and potential publication bias and sensitivity analyses were performed. Results 14 studies comprising 1822 patients with COVID-19 met the inclusion criteria, there were 1145 (62.8%) males and 677 (31.2%) females, and the mean age was 63.8 ± 16.1 years. The concentration of MR-proADM was compared between the survivors and non-survivors in 9 studies and the difference was significant (P < 0.01), I2 = 46%. The combined sensitivity was 0.86 [0.73–0.92], and the combined specificity was 0.78 [0.68–0.86]. We drew the summary receiver operating characteristic (SROC) curve and calculated the area under curve (AUC) = 0.90 [0.87–0.92]. An increase of 1 nmol/L of MR-proADM was independently associated with a more than threefold increase in mortality (odds ratio (OR) 3.03, 95% confidence interval (CI) 2.26–4.06, I2 = 0.0%, P = 0.633). The predictive value of MR-proADM for mortality was better than many other biomarkers. Conclusion MR-proADM had a very good predictive value for the poor prognosis of COVID-19 patients. Increased levels of MR-proADM were independently associated with mortality in COVID-19 patients and may allow a better risk stratification. |
| first_indexed | 2024-04-09T12:51:44Z |
| format | Article |
| id | doaj.art-837b5793f2ca401fa41e4e1073d04f88 |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-04-09T12:51:44Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-837b5793f2ca401fa41e4e1073d04f882023-05-14T11:10:04ZengBMCBMC Infectious Diseases1471-23342023-05-0123111210.1186/s12879-023-08275-zCirculating mid-regional proadrenomedullin is a predictor of mortality in patients with COVID-19: a systematic review and meta-analysisNa Wang0Lushan Liu1Wei He2Na Shang3Junyu Li4Zhou Qin5Xiaoxia Du6Emergency department of China Rehabilitation Research Center, Capital Medical UniversityEmergency department of China Rehabilitation Research Center, Capital Medical UniversityEmergency department of China Rehabilitation Research Center, Capital Medical UniversityEmergency department of China Rehabilitation Research Center, Capital Medical UniversityEmergency department of China Rehabilitation Research Center, Capital Medical UniversityEmergency department of China Rehabilitation Research Center, Capital Medical UniversityDepartment of neurorehabilitation of China Rehabilitation Research Center, Capital Medical UniversityAbstract Background Although there is increasing understanding of the changes in the laboratory parameters of Coronavirus disease 2019 (COVID-19), the correlation between circulating Mid-regional Proadrenomedullin (MR-proADM) and mortality of patients with COVID-19 is not fully understood. In this study, we conducted a systematic review and meta-analysis to evaluate the prognostic value of MR-proADM in patients with COVID-19. Methods The PubMed, Embase, Web of Science, Cochrane Library, Wanfang, SinoMed and Chinese National Knowledge Infrastructure (CNKI) databases were searched from 1 January 2020 to 20 March 2022 for relevant literature. The Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) was used to assess quality bias, STATA was employed to pool the effect size by a random effects model, and potential publication bias and sensitivity analyses were performed. Results 14 studies comprising 1822 patients with COVID-19 met the inclusion criteria, there were 1145 (62.8%) males and 677 (31.2%) females, and the mean age was 63.8 ± 16.1 years. The concentration of MR-proADM was compared between the survivors and non-survivors in 9 studies and the difference was significant (P < 0.01), I2 = 46%. The combined sensitivity was 0.86 [0.73–0.92], and the combined specificity was 0.78 [0.68–0.86]. We drew the summary receiver operating characteristic (SROC) curve and calculated the area under curve (AUC) = 0.90 [0.87–0.92]. An increase of 1 nmol/L of MR-proADM was independently associated with a more than threefold increase in mortality (odds ratio (OR) 3.03, 95% confidence interval (CI) 2.26–4.06, I2 = 0.0%, P = 0.633). The predictive value of MR-proADM for mortality was better than many other biomarkers. Conclusion MR-proADM had a very good predictive value for the poor prognosis of COVID-19 patients. Increased levels of MR-proADM were independently associated with mortality in COVID-19 patients and may allow a better risk stratification.https://doi.org/10.1186/s12879-023-08275-zMid-regional ProadrenomedullinCOVID-19MortalityMeta-analysis |
| spellingShingle | Na Wang Lushan Liu Wei He Na Shang Junyu Li Zhou Qin Xiaoxia Du Circulating mid-regional proadrenomedullin is a predictor of mortality in patients with COVID-19: a systematic review and meta-analysis BMC Infectious Diseases Mid-regional Proadrenomedullin COVID-19 Mortality Meta-analysis |
| title | Circulating mid-regional proadrenomedullin is a predictor of mortality in patients with COVID-19: a systematic review and meta-analysis |
| title_full | Circulating mid-regional proadrenomedullin is a predictor of mortality in patients with COVID-19: a systematic review and meta-analysis |
| title_fullStr | Circulating mid-regional proadrenomedullin is a predictor of mortality in patients with COVID-19: a systematic review and meta-analysis |
| title_full_unstemmed | Circulating mid-regional proadrenomedullin is a predictor of mortality in patients with COVID-19: a systematic review and meta-analysis |
| title_short | Circulating mid-regional proadrenomedullin is a predictor of mortality in patients with COVID-19: a systematic review and meta-analysis |
| title_sort | circulating mid regional proadrenomedullin is a predictor of mortality in patients with covid 19 a systematic review and meta analysis |
| topic | Mid-regional Proadrenomedullin COVID-19 Mortality Meta-analysis |
| url | https://doi.org/10.1186/s12879-023-08275-z |
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