Dexamethasone Induces the Expression and Function of Tryptophan-2-3-Dioxygenase in SK-MEL-28 Melanoma Cells

Dexamethasone Induces the Expression and Function of Tryptophan-2-3-Dioxygenase in SK-MEL-28 Melanoma Cells

Tryptophan-2,3-dioxygenase (TDO) is one of the key tryptophan-catabolizing enzymes with immunoregulatory properties in cancer. Contrary to expectation, clinical trials showed that inhibitors of the ubiquitously expressed enzyme, indoleamine-2,3-dioxygenase-1 (IDO1), do not provide benefits in melano...

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Bibliographic Details
Main Authors:	Marta Cecchi, Sara Paccosi, Angela Silvano, Ali Hussein Eid, Astrid Parenti
Format:	Article
Language:	English
Published:	MDPI AG 2021-03-01
Series:	Pharmaceuticals
Subjects:	SK-Mel-28 melanoma tryptophan-2,3-dioxygenase indoleamine-2,3-dioxygenase-1 dexamethasone 680C91
Online Access:	https://www.mdpi.com/1424-8247/14/3/211

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