Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models

Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models

Abstract Alzheimer’s disease (AD) is characterized by neurotoxicity mediated by the accumulation of beta amyloid (Aβ) oligomers, causing neuronal loss and progressive cognitive decline. Genetic deletion or chronic pharmacological inhibition of mGluR5 by the negative allosteric modulator CTEP, rescue...

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Bibliographic Details
Main Authors: Khaled S. Abd-Elrahman, Alison Hamilton, Maryam Vasefi, Stephen S. G. Ferguson
Format: Article
Language:English
Published: BMC 2018-04-01
Series:Molecular Brain
Subjects:
GPCR
mGluR5
Alzheimer’s disease
APPswe/PS1ΔE9
3xTg-AD
CTEP
Online Access:http://link.springer.com/article/10.1186/s13041-018-0364-9

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