Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models

Autophagy is increased following either pharmacological or genetic silencing of mGluR5 signaling in Alzheimer’s disease mouse models

Abstract Alzheimer’s disease (AD) is characterized by neurotoxicity mediated by the accumulation of beta amyloid (Aβ) oligomers, causing neuronal loss and progressive cognitive decline. Genetic deletion or chronic pharmacological inhibition of mGluR5 by the negative allosteric modulator CTEP, rescue...

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Podrobná bibliografie
Hlavní autoři: Khaled S. Abd-Elrahman, Alison Hamilton, Maryam Vasefi, Stephen S. G. Ferguson
Médium: Článek
Jazyk:English
Vydáno: BMC 2018-04-01
Edice:Molecular Brain
Témata:
GPCR
mGluR5
Alzheimer’s disease
APPswe/PS1ΔE9
3xTg-AD
CTEP
On-line přístup:http://link.springer.com/article/10.1186/s13041-018-0364-9

Internet

http://link.springer.com/article/10.1186/s13041-018-0364-9

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