Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019)
Introduction: Following the wide distribution of non-invasive prenatal genetic screening (NIPS), numerous studies have reported a decline in total invasive tests in the recent years, up to 50–70% in some countries. However, in Denmark and Israel we have not experienced these declines. The objective...
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Frontiers Media S.A.
2021-11-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.768997/full |
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| author | Lena Sagi-Dain Amihood Singer Olav B. Petersen Olav B. Petersen Stina Lou Ida Vogel Ida Vogel |
| author_facet | Lena Sagi-Dain Amihood Singer Olav B. Petersen Olav B. Petersen Stina Lou Ida Vogel Ida Vogel |
| author_sort | Lena Sagi-Dain |
| collection | DOAJ |
| description | Introduction: Following the wide distribution of non-invasive prenatal genetic screening (NIPS), numerous studies have reported a decline in total invasive tests in the recent years, up to 50–70% in some countries. However, in Denmark and Israel we have not experienced these declines. The objective of our study was to evaluate the trends in NIPS and chromosomal microarray analysis (CMA) use in Denmark and Israel.Methods: This retrospective study was performed by data acquisition from the Danish Cytogenetics Central Registry throughout the years 2000–2019, and Israeli Public Health Services, Ministry of Health computerized database (from 2011).Results: Of the 1,243,956 live births registered in Denmark over the years 2000–2019, a relatively steady level of invasive testing around 6% was noted since 2004, as opposed to 13.0% in Israel based on 1,594,962 live births between 2011 and 2019. The average uptake of NIPS was 1.1 ± 0.5% in Denmark vs. 4.3% in Israel (2013–2019). Relatively steady rates of invasive testing were noted in both countries, compared to a slight decline in NIPS in the recent years.Discussion: The recent decrease in the rates of invasive testing in the NIPS era was not observed in Denmark or in Israel. These results imply that Danish and Israeli women and/or health providers might favor the high resolution and yield of CMA testing over the non-invasiveness of NIPS. We explore and discuss this phenomenon, based on five central factors. |
| first_indexed | 2024-12-20T19:14:32Z |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-20T19:14:32Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-837d6e54c04e4c5eab9a6e01afad5d312022-12-21T19:29:08ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2021-11-01810.3389/fmed.2021.768997768997Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019)Lena Sagi-Dain0Amihood Singer1Olav B. Petersen2Olav B. Petersen3Stina Lou4Ida Vogel5Ida Vogel6Prenatal Genetics, Genetics Institute, Carmel Medical Center, Affiliated to the Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, IsraelCommunity Genetics, Public Health Services, Ministry of Health, Jerusalem, IsraelDepartment of Obstetrics, Center for Fetal Medicine, Copenhagen University Hospital Rigshospitalet, Copenhagen, DenmarkDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, DenmarkCenter for Fetal Diagnostics, Aarhus University, Aarhus, DenmarkCenter for Fetal Diagnostics, Aarhus University, Aarhus, DenmarkDepartment of Clinical Genetics, Aarhus University Hospital, Aarhus, DenmarkIntroduction: Following the wide distribution of non-invasive prenatal genetic screening (NIPS), numerous studies have reported a decline in total invasive tests in the recent years, up to 50–70% in some countries. However, in Denmark and Israel we have not experienced these declines. The objective of our study was to evaluate the trends in NIPS and chromosomal microarray analysis (CMA) use in Denmark and Israel.Methods: This retrospective study was performed by data acquisition from the Danish Cytogenetics Central Registry throughout the years 2000–2019, and Israeli Public Health Services, Ministry of Health computerized database (from 2011).Results: Of the 1,243,956 live births registered in Denmark over the years 2000–2019, a relatively steady level of invasive testing around 6% was noted since 2004, as opposed to 13.0% in Israel based on 1,594,962 live births between 2011 and 2019. The average uptake of NIPS was 1.1 ± 0.5% in Denmark vs. 4.3% in Israel (2013–2019). Relatively steady rates of invasive testing were noted in both countries, compared to a slight decline in NIPS in the recent years.Discussion: The recent decrease in the rates of invasive testing in the NIPS era was not observed in Denmark or in Israel. These results imply that Danish and Israeli women and/or health providers might favor the high resolution and yield of CMA testing over the non-invasiveness of NIPS. We explore and discuss this phenomenon, based on five central factors.https://www.frontiersin.org/articles/10.3389/fmed.2021.768997/fullchromosomal microarray analysischromosome aberrationprenatal testingnon-invasive prenatal screeninginvasive testing |
| spellingShingle | Lena Sagi-Dain Amihood Singer Olav B. Petersen Olav B. Petersen Stina Lou Ida Vogel Ida Vogel Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019) Frontiers in Medicine chromosomal microarray analysis chromosome aberration prenatal testing non-invasive prenatal screening invasive testing |
| title | Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019) |
| title_full | Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019) |
| title_fullStr | Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019) |
| title_full_unstemmed | Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019) |
| title_short | Trends in Non-invasive Prenatal Screening and Invasive Testing in Denmark (2000–2019) and Israel (2011–2019) |
| title_sort | trends in non invasive prenatal screening and invasive testing in denmark 2000 2019 and israel 2011 2019 |
| topic | chromosomal microarray analysis chromosome aberration prenatal testing non-invasive prenatal screening invasive testing |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.768997/full |
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