Ig constant region effects on variable region structure and function
The adaptive humoral immune response is responsible for the generation of antimicrobial proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a defense system against pathogenic microbes and toxins by targeting them for removal and/or destruction. Historically, antibodies...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-02-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00022/full |
| _version_ | 1818263897196462080 |
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| author | Alena eJanda Anthony eBowen Neil S Greenspan Arturo eCasadevall |
| author_facet | Alena eJanda Anthony eBowen Neil S Greenspan Arturo eCasadevall |
| author_sort | Alena eJanda |
| collection | DOAJ |
| description | The adaptive humoral immune response is responsible for the generation of antimicrobial proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a defense system against pathogenic microbes and toxins by targeting them for removal and/or destruction. Historically, antibodies have been thought to be comprised of distinct structural domains known as the variable and constant regions that are responsible for antigen binding and mediating effector functions such as opsonization and complement activation, respectively. These domains were thought to be structurally and functionally independent. Recent work has revealed however, that in some families of antibodies, the two regions can influence each other. We will discuss the body of work that led to these observations, as well as the mechanisms that have been proposed to explain how these two different antibody regions may interact in the function of antigen binding. |
| first_indexed | 2024-12-12T19:26:19Z |
| format | Article |
| id | doaj.art-837e6bd96e144abc9332dfb28627e515 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-12T19:26:19Z |
| publishDate | 2016-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-837e6bd96e144abc9332dfb28627e5152022-12-22T00:14:31ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2016-02-01710.3389/fmicb.2016.00022172484Ig constant region effects on variable region structure and functionAlena eJanda0Anthony eBowen1Neil S Greenspan2Arturo eCasadevall3Albert Einstein College of MedicineAlbert Einstein College of MedicineCase Western Reserve UniversityJohns Hopkins Bloomberg School of Public HealthThe adaptive humoral immune response is responsible for the generation of antimicrobial proteins known as immunoglobulin molecules or antibodies. Immunoglobulins provide a defense system against pathogenic microbes and toxins by targeting them for removal and/or destruction. Historically, antibodies have been thought to be comprised of distinct structural domains known as the variable and constant regions that are responsible for antigen binding and mediating effector functions such as opsonization and complement activation, respectively. These domains were thought to be structurally and functionally independent. Recent work has revealed however, that in some families of antibodies, the two regions can influence each other. We will discuss the body of work that led to these observations, as well as the mechanisms that have been proposed to explain how these two different antibody regions may interact in the function of antigen binding.http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00022/fullStructureimmunoglobulinfunctionisotypeVariable regionConstant region |
| spellingShingle | Alena eJanda Anthony eBowen Neil S Greenspan Arturo eCasadevall Ig constant region effects on variable region structure and function Frontiers in Microbiology Structure immunoglobulin function isotype Variable region Constant region |
| title | Ig constant region effects on variable region structure and function |
| title_full | Ig constant region effects on variable region structure and function |
| title_fullStr | Ig constant region effects on variable region structure and function |
| title_full_unstemmed | Ig constant region effects on variable region structure and function |
| title_short | Ig constant region effects on variable region structure and function |
| title_sort | ig constant region effects on variable region structure and function |
| topic | Structure immunoglobulin function isotype Variable region Constant region |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.00022/full |
| work_keys_str_mv | AT alenaejanda igconstantregioneffectsonvariableregionstructureandfunction AT anthonyebowen igconstantregioneffectsonvariableregionstructureandfunction AT neilsgreenspan igconstantregioneffectsonvariableregionstructureandfunction AT arturoecasadevall igconstantregioneffectsonvariableregionstructureandfunction |