Exploring shared neural substrates underlying cognition and gait variability in adults without dementia
Abstract Background High gait variability is associated with neurodegeneration and cognitive impairments and is predictive of cognitive impairment and dementia. The objective of this study was to identify cortical or subcortical structures of the brain shared by gait variability measured using a bod...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Alzheimer’s Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13195-023-01354-y |
| _version_ | 1797415772813787136 |
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| author | Seonjeong Byun Hyang Jun Lee Jun Sung Kim Euna Choi Subin Lee Tae Hui Kim Jae Hyoung Kim Ji Won Han Ki Woong Kim |
| author_facet | Seonjeong Byun Hyang Jun Lee Jun Sung Kim Euna Choi Subin Lee Tae Hui Kim Jae Hyoung Kim Ji Won Han Ki Woong Kim |
| author_sort | Seonjeong Byun |
| collection | DOAJ |
| description | Abstract Background High gait variability is associated with neurodegeneration and cognitive impairments and is predictive of cognitive impairment and dementia. The objective of this study was to identify cortical or subcortical structures of the brain shared by gait variability measured using a body-worn tri-axial accelerometer (TAA) and cognitive function. Methods This study is a part of a larger population-based cohort study on cognitive aging and dementia. The study included 207 participants without dementia, with a mean age of 72.6, and 45.4% of them are females. We conducted standardized diagnostic interview including a detailed medical history, physical and neurological examinations, and laboratory tests for cognitive impairment. We obtained gait variability during walking using a body-worn TAA along and measured cortical thickness and subcortical volume from brain magnetic resonance (MR) images. We cross-sectionally investigated the cortical and subcortical neural structures associated with gait variability and the shared neural substrates of gait variability and cognitive function. Results Higher gait variability was associated with the lower cognitive function and thinner cortical gray matter but not smaller subcortical structures. Among the clusters exhibiting correlations with gait variability, one that included the inferior temporal, entorhinal, parahippocampal, fusiform, and lingual regions in the left hemisphere was also associated with global cognitive and verbal memory function. Mediation analysis results revealed that the cluster’s cortical thickness played a mediating role in the association between gait variability and cognitive function. Conclusion Gait variability and cognitive function may share neural substrates, specifically in regions related to memory and visuospatial navigation. |
| first_indexed | 2024-03-09T05:54:23Z |
| format | Article |
| id | doaj.art-837efc92d2f14af9ae4f958d5cabb4f0 |
| institution | Directory Open Access Journal |
| issn | 1758-9193 |
| language | English |
| last_indexed | 2024-03-09T05:54:23Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Alzheimer’s Research & Therapy |
| spelling | doaj.art-837efc92d2f14af9ae4f958d5cabb4f02023-12-03T12:14:36ZengBMCAlzheimer’s Research & Therapy1758-91932023-11-011511910.1186/s13195-023-01354-yExploring shared neural substrates underlying cognition and gait variability in adults without dementiaSeonjeong Byun0Hyang Jun Lee1Jun Sung Kim2Euna Choi3Subin Lee4Tae Hui Kim5Jae Hyoung Kim6Ji Won Han7Ki Woong Kim8Department of Neuropsychiatry, College of Medicine, Uijeongbu St Mary’s Hospital, The Catholic University of KoreaDepartment of Neuropsychiatry, Seoul National University Bundang HospitalInstitute of Human Behavioral Medicine, Seoul National University Medical Research CenterDepartment of Brain and Cognitive Sciences, Seoul National University College of Natural SciencesLaboratory for Imaging Science and Technology, Department of Electrical and Computer Engineering, Seoul National UniversityDepartment of Psychiatry, Yonsei University Wonju Severance Christian HospitalDepartment of Radiology, Seoul National University Bundang HospitalDepartment of Neuropsychiatry, Seoul National University Bundang HospitalDepartment of Neuropsychiatry, Seoul National University Bundang HospitalAbstract Background High gait variability is associated with neurodegeneration and cognitive impairments and is predictive of cognitive impairment and dementia. The objective of this study was to identify cortical or subcortical structures of the brain shared by gait variability measured using a body-worn tri-axial accelerometer (TAA) and cognitive function. Methods This study is a part of a larger population-based cohort study on cognitive aging and dementia. The study included 207 participants without dementia, with a mean age of 72.6, and 45.4% of them are females. We conducted standardized diagnostic interview including a detailed medical history, physical and neurological examinations, and laboratory tests for cognitive impairment. We obtained gait variability during walking using a body-worn TAA along and measured cortical thickness and subcortical volume from brain magnetic resonance (MR) images. We cross-sectionally investigated the cortical and subcortical neural structures associated with gait variability and the shared neural substrates of gait variability and cognitive function. Results Higher gait variability was associated with the lower cognitive function and thinner cortical gray matter but not smaller subcortical structures. Among the clusters exhibiting correlations with gait variability, one that included the inferior temporal, entorhinal, parahippocampal, fusiform, and lingual regions in the left hemisphere was also associated with global cognitive and verbal memory function. Mediation analysis results revealed that the cluster’s cortical thickness played a mediating role in the association between gait variability and cognitive function. Conclusion Gait variability and cognitive function may share neural substrates, specifically in regions related to memory and visuospatial navigation.https://doi.org/10.1186/s13195-023-01354-yGaitTri-axial accelerometerCognitive impairmentDigital biomarkerShared neural network |
| spellingShingle | Seonjeong Byun Hyang Jun Lee Jun Sung Kim Euna Choi Subin Lee Tae Hui Kim Jae Hyoung Kim Ji Won Han Ki Woong Kim Exploring shared neural substrates underlying cognition and gait variability in adults without dementia Alzheimer’s Research & Therapy Gait Tri-axial accelerometer Cognitive impairment Digital biomarker Shared neural network |
| title | Exploring shared neural substrates underlying cognition and gait variability in adults without dementia |
| title_full | Exploring shared neural substrates underlying cognition and gait variability in adults without dementia |
| title_fullStr | Exploring shared neural substrates underlying cognition and gait variability in adults without dementia |
| title_full_unstemmed | Exploring shared neural substrates underlying cognition and gait variability in adults without dementia |
| title_short | Exploring shared neural substrates underlying cognition and gait variability in adults without dementia |
| title_sort | exploring shared neural substrates underlying cognition and gait variability in adults without dementia |
| topic | Gait Tri-axial accelerometer Cognitive impairment Digital biomarker Shared neural network |
| url | https://doi.org/10.1186/s13195-023-01354-y |
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