A141
The aim of this study was to investigate the quantitative changes in the phospholipid (PL) content of peripheral blood mononuclear cells (MNC), plasma membrane (PM), fraction in breast (BC) and cervical cancers (CC) compared to normal levels. Eight PL fractions were identified by TLC method in the P...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-11-01
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| Series: | EJC Supplements |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1359634915000221 |
| _version_ | 1818108393618931712 |
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| author | H. Davtyan G. Hakobyan K. Alexsanyan Y. Tadevosyan |
| author_facet | H. Davtyan G. Hakobyan K. Alexsanyan Y. Tadevosyan |
| author_sort | H. Davtyan |
| collection | DOAJ |
| description | The aim of this study was to investigate the quantitative changes in the phospholipid (PL) content of peripheral blood mononuclear cells (MNC), plasma membrane (PM), fraction in breast (BC) and cervical cancers (CC) compared to normal levels. Eight PL fractions were identified by TLC method in the PM of MNC, namely: lysophosphatidylcholines (LPC), sphingomyelins (SPM), phosphatidylcholines (PC), phosphatidylinositols (PI), phosphatidylserines (PS), phosphatidylethanolamines (PE), phosphatidic acids (PA) and diphosphatidylglycerols (DPG). Data obtained indicate that all PLs, quantified in this study, were significantly altered in blood MNC of cancer patients compared to healthy individuals. It was shown that compared to norm levels of LPC, PC, PE fractions were reliable increased in BC and CC, when PI, PS, PA – decreased. Notably, regular disturbances reveled in BC and CC were identical with those observed earlier in chronic lymphocytic leukemia and also distinctly individual for each patient. We conclude that alterations in PLs content of crude MNC PMs have been associated with disease pathology and similarly involved in the onset and evolution of diverse forms of cancer. These data can be useful for prospective biomarkers selection and cancer definition as well as for discovery of new personalized treatment modes. |
| first_indexed | 2024-12-11T02:14:39Z |
| format | Article |
| id | doaj.art-837f83c135624172a507fc864bac56e2 |
| institution | Directory Open Access Journal |
| issn | 1359-6349 |
| language | English |
| last_indexed | 2024-12-11T02:14:39Z |
| publishDate | 2015-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EJC Supplements |
| spelling | doaj.art-837f83c135624172a507fc864bac56e22022-12-22T01:24:12ZengElsevierEJC Supplements1359-63492015-11-011311210.1016/j.ejcsup.2015.08.021A141H. Davtyan0G. Hakobyan1K. Alexsanyan2Y. Tadevosyan3Institute of Molecular Biology, NAS RA, Yerevan, ArmeniaInstitute of Molecular Biology, NAS RA, Yerevan, ArmeniaNational Center of Oncology after V.Fanarjyan, MH RA, Yerevan, ArmeniaInstitute of Molecular Biology, NAS RA, Yerevan, ArmeniaThe aim of this study was to investigate the quantitative changes in the phospholipid (PL) content of peripheral blood mononuclear cells (MNC), plasma membrane (PM), fraction in breast (BC) and cervical cancers (CC) compared to normal levels. Eight PL fractions were identified by TLC method in the PM of MNC, namely: lysophosphatidylcholines (LPC), sphingomyelins (SPM), phosphatidylcholines (PC), phosphatidylinositols (PI), phosphatidylserines (PS), phosphatidylethanolamines (PE), phosphatidic acids (PA) and diphosphatidylglycerols (DPG). Data obtained indicate that all PLs, quantified in this study, were significantly altered in blood MNC of cancer patients compared to healthy individuals. It was shown that compared to norm levels of LPC, PC, PE fractions were reliable increased in BC and CC, when PI, PS, PA – decreased. Notably, regular disturbances reveled in BC and CC were identical with those observed earlier in chronic lymphocytic leukemia and also distinctly individual for each patient. We conclude that alterations in PLs content of crude MNC PMs have been associated with disease pathology and similarly involved in the onset and evolution of diverse forms of cancer. These data can be useful for prospective biomarkers selection and cancer definition as well as for discovery of new personalized treatment modes.http://www.sciencedirect.com/science/article/pii/S1359634915000221 |
| spellingShingle | H. Davtyan G. Hakobyan K. Alexsanyan Y. Tadevosyan A141 EJC Supplements |
| title | A141 |
| title_full | A141 |
| title_fullStr | A141 |
| title_full_unstemmed | A141 |
| title_short | A141 |
| title_sort | a141 |
| url | http://www.sciencedirect.com/science/article/pii/S1359634915000221 |
| work_keys_str_mv | AT hdavtyan a141 AT ghakobyan a141 AT kalexsanyan a141 AT ytadevosyan a141 |