Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response
Porcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus (CoV), is the causative agent of porcine epidemic diarrhea (PED). PED causes lethal watery diarrhea in piglets, which has led to substantial economic losses in many countries and is a great threat to the global swine indust...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/5/367 |
| _version_ | 1797568310517170176 |
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| author | Shasha Li Jinping Yang Zixiang Zhu Haixue Zheng |
| author_facet | Shasha Li Jinping Yang Zixiang Zhu Haixue Zheng |
| author_sort | Shasha Li |
| collection | DOAJ |
| description | Porcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus (CoV), is the causative agent of porcine epidemic diarrhea (PED). PED causes lethal watery diarrhea in piglets, which has led to substantial economic losses in many countries and is a great threat to the global swine industry. Interferons (IFNs) are major cytokines involved in host innate immune defense, which induce the expression of a broad range of antiviral effectors that help host to control and antagonize viral infections. PEDV infection does not elicit a robust IFN response, and some of the mechanisms used by the virus to counteract the host innate immune response have been unraveled. PEDV evades the host innate immune response by two main strategies including: 1) encoding IFN antagonists to disrupt innate immune pathway, and 2) hiding its viral RNA to avoid the exposure of viral RNA to immune sensors. This review highlights the immune evasion mechanisms employed by PEDV, which provides insights for the better understanding of PEDV-host interactions and developing effective vaccines and antivirals against CoVs. |
| first_indexed | 2024-03-10T19:54:36Z |
| format | Article |
| id | doaj.art-83813e2570d645bbbb223dc68960feda |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T19:54:36Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-83813e2570d645bbbb223dc68960feda2023-11-20T00:03:53ZengMDPI AGPathogens2076-08172020-05-019536710.3390/pathogens9050367Porcine Epidemic Diarrhea Virus and the Host Innate Immune ResponseShasha Li0Jinping Yang1Zixiang Zhu2Haixue Zheng3State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, ChinaState Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, ChinaPorcine epidemic diarrhea virus (PEDV), a swine enteropathogenic coronavirus (CoV), is the causative agent of porcine epidemic diarrhea (PED). PED causes lethal watery diarrhea in piglets, which has led to substantial economic losses in many countries and is a great threat to the global swine industry. Interferons (IFNs) are major cytokines involved in host innate immune defense, which induce the expression of a broad range of antiviral effectors that help host to control and antagonize viral infections. PEDV infection does not elicit a robust IFN response, and some of the mechanisms used by the virus to counteract the host innate immune response have been unraveled. PEDV evades the host innate immune response by two main strategies including: 1) encoding IFN antagonists to disrupt innate immune pathway, and 2) hiding its viral RNA to avoid the exposure of viral RNA to immune sensors. This review highlights the immune evasion mechanisms employed by PEDV, which provides insights for the better understanding of PEDV-host interactions and developing effective vaccines and antivirals against CoVs.https://www.mdpi.com/2076-0817/9/5/367coronavirusporcine epidemic diarrhea virusinnate immunitytype I IFNimmune evasion |
| spellingShingle | Shasha Li Jinping Yang Zixiang Zhu Haixue Zheng Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response Pathogens coronavirus porcine epidemic diarrhea virus innate immunity type I IFN immune evasion |
| title | Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response |
| title_full | Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response |
| title_fullStr | Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response |
| title_full_unstemmed | Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response |
| title_short | Porcine Epidemic Diarrhea Virus and the Host Innate Immune Response |
| title_sort | porcine epidemic diarrhea virus and the host innate immune response |
| topic | coronavirus porcine epidemic diarrhea virus innate immunity type I IFN immune evasion |
| url | https://www.mdpi.com/2076-0817/9/5/367 |
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