Non-Invasive Retinal Blood Vessel Wall Measurements with Polarization-Sensitive Optical Coherence Tomography for Diabetes Assessment: A Quantitative Study
Diabetes affects the structure of the blood vessel walls. Since the blood vessel walls are made of birefringent organized tissue, any change or damage to this organization can be evaluated using polarization-sensitive optical coherence tomography (PS-OCT). In this paper, we used PS-OCT along with th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/8/1230 |
| _version_ | 1797585394201526272 |
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| author | Hadi Afsharan Dilusha Silva Chulmin Joo Barry Cense |
| author_facet | Hadi Afsharan Dilusha Silva Chulmin Joo Barry Cense |
| author_sort | Hadi Afsharan |
| collection | DOAJ |
| description | Diabetes affects the structure of the blood vessel walls. Since the blood vessel walls are made of birefringent organized tissue, any change or damage to this organization can be evaluated using polarization-sensitive optical coherence tomography (PS-OCT). In this paper, we used PS-OCT along with the blood vessel wall birefringence index (BBI = thickness/birefringence<sup>2</sup>) to non-invasively assess the structural integrity of the human retinal blood vessel walls in patients with diabetes and compared the results to those of healthy subjects. PS-OCT measurements revealed that blood vessel walls of diabetic patients exhibit a much higher birefringence while having the same wall thickness and therefore lower BBI values. Applying BBI to diagnose diabetes demonstrated high accuracy (93%), sensitivity (93%) and specificity (93%). PS-OCT measurements can quantify small changes in the polarization properties of retinal vessel walls associated with diabetes, which provides researchers with a new imaging tool to determine the effects of exercise, medication, and alternative diets on the development of diabetes. |
| first_indexed | 2024-03-11T00:05:31Z |
| format | Article |
| id | doaj.art-83827b417dca4e829997099cf644bf1d |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T00:05:31Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-83827b417dca4e829997099cf644bf1d2023-11-19T00:24:03ZengMDPI AGBiomolecules2218-273X2023-08-01138123010.3390/biom13081230Non-Invasive Retinal Blood Vessel Wall Measurements with Polarization-Sensitive Optical Coherence Tomography for Diabetes Assessment: A Quantitative StudyHadi Afsharan0Dilusha Silva1Chulmin Joo2Barry Cense3Optical+Biomedical Engineering Laboratory, Department of Electrical, Electronic and Computer Engineering, The University of Western Australia, Perth, WA 6009, AustraliaMicroelectronics Research Group, Department of Electrical, Electronic and Computer Engineering, The University of Western Australia, Perth, WA 6009, AustraliaDepartment of Mechanical Engineering, Yonsei University, Seodaemun-gu, Seoul 03722, Republic of KoreaOptical+Biomedical Engineering Laboratory, Department of Electrical, Electronic and Computer Engineering, The University of Western Australia, Perth, WA 6009, AustraliaDiabetes affects the structure of the blood vessel walls. Since the blood vessel walls are made of birefringent organized tissue, any change or damage to this organization can be evaluated using polarization-sensitive optical coherence tomography (PS-OCT). In this paper, we used PS-OCT along with the blood vessel wall birefringence index (BBI = thickness/birefringence<sup>2</sup>) to non-invasively assess the structural integrity of the human retinal blood vessel walls in patients with diabetes and compared the results to those of healthy subjects. PS-OCT measurements revealed that blood vessel walls of diabetic patients exhibit a much higher birefringence while having the same wall thickness and therefore lower BBI values. Applying BBI to diagnose diabetes demonstrated high accuracy (93%), sensitivity (93%) and specificity (93%). PS-OCT measurements can quantify small changes in the polarization properties of retinal vessel walls associated with diabetes, which provides researchers with a new imaging tool to determine the effects of exercise, medication, and alternative diets on the development of diabetes.https://www.mdpi.com/2218-273X/13/8/1230PS-OCTdiabetesblood vessel wall birefringence index (BBI)retinal imagingretinal blood vessels |
| spellingShingle | Hadi Afsharan Dilusha Silva Chulmin Joo Barry Cense Non-Invasive Retinal Blood Vessel Wall Measurements with Polarization-Sensitive Optical Coherence Tomography for Diabetes Assessment: A Quantitative Study Biomolecules PS-OCT diabetes blood vessel wall birefringence index (BBI) retinal imaging retinal blood vessels |
| title | Non-Invasive Retinal Blood Vessel Wall Measurements with Polarization-Sensitive Optical Coherence Tomography for Diabetes Assessment: A Quantitative Study |
| title_full | Non-Invasive Retinal Blood Vessel Wall Measurements with Polarization-Sensitive Optical Coherence Tomography for Diabetes Assessment: A Quantitative Study |
| title_fullStr | Non-Invasive Retinal Blood Vessel Wall Measurements with Polarization-Sensitive Optical Coherence Tomography for Diabetes Assessment: A Quantitative Study |
| title_full_unstemmed | Non-Invasive Retinal Blood Vessel Wall Measurements with Polarization-Sensitive Optical Coherence Tomography for Diabetes Assessment: A Quantitative Study |
| title_short | Non-Invasive Retinal Blood Vessel Wall Measurements with Polarization-Sensitive Optical Coherence Tomography for Diabetes Assessment: A Quantitative Study |
| title_sort | non invasive retinal blood vessel wall measurements with polarization sensitive optical coherence tomography for diabetes assessment a quantitative study |
| topic | PS-OCT diabetes blood vessel wall birefringence index (BBI) retinal imaging retinal blood vessels |
| url | https://www.mdpi.com/2218-273X/13/8/1230 |
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