Age-Dependent Alterations of Cognition, Mitochondrial Function, and Beta-Amyloid Deposition in a Murine Model of Alzheimer’s Disease—A Longitudinal Study

Age-Dependent Alterations of Cognition, Mitochondrial Function, and Beta-Amyloid Deposition in a Murine Model of Alzheimer’s Disease—A Longitudinal Study

Aging is the main risk factor for sporadic Alzheimer’s disease (AD), which is characterized by the cerebral deposition of β-amyloid peptides (Aβ) and cognitive decline. Mitochondrial dysfunction is also characteristic of the disease and represents a hallmark of both, aging and neurodegeneration. We...

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Bibliographic Details
Main Authors: Martina Reutzel, Rekha Grewal, Aljoscha Joppe, Gunter P. Eckert
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
mitochondrial dysfunction
amyloid-beta
Alzheimers’s disease
transgenic mouse models
longitudinal studies
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.875989/full

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