Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cells
Plants have been seen to possess the potential to be excellent biological matrices to serve as a basis for investigating the presence of promising therapeutic agents for cancer treatment. Several successful anti-cancer medicines - or their analogues - nowadays in use are plant derived and many more...
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| Format: | Article |
| Language: | English |
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Sciendo
2020-04-01
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| Series: | The EuroBiotech Journal |
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| Online Access: | https://doi.org/10.2478/ebtj-2020-0012 |
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| author | Najjaa Hanen Abdelkarim Ben Arfa Doria Enrico Boubakri Abdelbasset Trabelsi Najla Falleh Hanen Tlili Hajer Neffati Mohamed |
| author_facet | Najjaa Hanen Abdelkarim Ben Arfa Doria Enrico Boubakri Abdelbasset Trabelsi Najla Falleh Hanen Tlili Hajer Neffati Mohamed |
| author_sort | Najjaa Hanen |
| collection | DOAJ |
| description | Plants have been seen to possess the potential to be excellent biological matrices to serve as a basis for investigating the presence of promising therapeutic agents for cancer treatment. Several successful anti-cancer medicines - or their analogues - nowadays in use are plant derived and many more are under clinical trials. Under current circumstances, the purpose of this work was to test aqueous and ethanolic extracts of five aromatic and medicinal plants from arid zones on some tumor cell lines. These plants, Cymbopogon schoenanthus (L.) Spreng, Crithmum maritimum (L.) Spreng, Hammada scoparia (Pomel) Iljin, Retama raetam (Forssk.) and Zizyphus lotus (L.) Desf., widely used in Tunisian ethnomedicine, were assessed for their phenolic compounds, antioxidants and anticancer activities in aqueous and ethanol extracts. Total polyphenols, flavonoid and tannin contents were determined colorimetrically and some of these molecules were identified using RP-HPLC. A significant difference on phenolic contents and composition were found among the investigated plants. Cymbopogon schoenanthus was the richest in phenolic compounds (approx. 72%) with quercetine-3-o-rhamnoside (approx. 33%) as main contributor. For all the tested plants, the highest antioxidant capacity was detected in the ethanolic extracts rather than in the aqueous ones. The highest antiproliferative potential was observed for the ethanolic extracts. Hammada scoparia, Retama raetam and Zizyphus lotus exhibited important antiproliferative effect that reached 67% at a 1% extract concentration. Taken together, the present study supports the potential development of chemotherapeutic agents from, at least, four of the five studied Tunisian ethnomedicinal plants. |
| first_indexed | 2024-12-17T13:40:27Z |
| format | Article |
| id | doaj.art-83837de1deea493da02ef6611febc3ff |
| institution | Directory Open Access Journal |
| issn | 2564-615X |
| language | English |
| last_indexed | 2024-12-17T13:40:27Z |
| publishDate | 2020-04-01 |
| publisher | Sciendo |
| record_format | Article |
| series | The EuroBiotech Journal |
| spelling | doaj.art-83837de1deea493da02ef6611febc3ff2022-12-21T21:46:17ZengSciendoThe EuroBiotech Journal2564-615X2020-04-014210411210.2478/ebtj-2020-0012ebtj-2020-0012Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cellsNajjaa Hanen0Abdelkarim Ben Arfa1Doria Enrico2Boubakri Abdelbasset3Trabelsi Najla4Falleh Hanen5Tlili Hajer6Neffati Mohamed7Laboratoire des Ecosystèmes Pastoraux et Valorisation des Plantes Spontanées et des Micro-organismes Associés, Institut des Régions Arides, 4119, Médenine, TunisiaLaboratoire des Ecosystèmes Pastoraux et Valorisation des Plantes Spontanées et des Micro-organismes Associés, Institut des Régions Arides, 4119, Médenine, TunisiaDepatement of Biology and Biotechnology, University of Pavia, PaviaItalyLaboratoire des Ecosystèmes Pastoraux et Valorisation des Plantes Spontanées et des Micro-organismes Associés, Institut des Régions Arides, 4119, Médenine, TunisiaLaboratory of Olive Biotechnology, Center of Biotechnology of Borj Cédria, CédriaTunisiaLaboratory of Olive Biotechnology, Center of Biotechnology of Borj Cédria, CédriaTunisiaLaboratoire des Ecosystèmes Pastoraux et Valorisation des Plantes Spontanées et des Micro-organismes Associés, Institut des Régions Arides, 4119, Médenine, TunisiaLaboratoire des Ecosystèmes Pastoraux et Valorisation des Plantes Spontanées et des Micro-organismes Associés, Institut des Régions Arides, 4119, Médenine, TunisiaPlants have been seen to possess the potential to be excellent biological matrices to serve as a basis for investigating the presence of promising therapeutic agents for cancer treatment. Several successful anti-cancer medicines - or their analogues - nowadays in use are plant derived and many more are under clinical trials. Under current circumstances, the purpose of this work was to test aqueous and ethanolic extracts of five aromatic and medicinal plants from arid zones on some tumor cell lines. These plants, Cymbopogon schoenanthus (L.) Spreng, Crithmum maritimum (L.) Spreng, Hammada scoparia (Pomel) Iljin, Retama raetam (Forssk.) and Zizyphus lotus (L.) Desf., widely used in Tunisian ethnomedicine, were assessed for their phenolic compounds, antioxidants and anticancer activities in aqueous and ethanol extracts. Total polyphenols, flavonoid and tannin contents were determined colorimetrically and some of these molecules were identified using RP-HPLC. A significant difference on phenolic contents and composition were found among the investigated plants. Cymbopogon schoenanthus was the richest in phenolic compounds (approx. 72%) with quercetine-3-o-rhamnoside (approx. 33%) as main contributor. For all the tested plants, the highest antioxidant capacity was detected in the ethanolic extracts rather than in the aqueous ones. The highest antiproliferative potential was observed for the ethanolic extracts. Hammada scoparia, Retama raetam and Zizyphus lotus exhibited important antiproliferative effect that reached 67% at a 1% extract concentration. Taken together, the present study supports the potential development of chemotherapeutic agents from, at least, four of the five studied Tunisian ethnomedicinal plants.https://doi.org/10.2478/ebtj-2020-0012antioxidant capacityantiproliferative potentialbreast cancerphenolic compoundstraditional medicinal plants |
| spellingShingle | Najjaa Hanen Abdelkarim Ben Arfa Doria Enrico Boubakri Abdelbasset Trabelsi Najla Falleh Hanen Tlili Hajer Neffati Mohamed Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cells The EuroBiotech Journal antioxidant capacity antiproliferative potential breast cancer phenolic compounds traditional medicinal plants |
| title | Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cells |
| title_full | Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cells |
| title_fullStr | Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cells |
| title_full_unstemmed | Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cells |
| title_short | Phenolic composition of some Tunisian medicinal plants associated with anti-proliferative effect on human breast cancer MCF-7 cells |
| title_sort | phenolic composition of some tunisian medicinal plants associated with anti proliferative effect on human breast cancer mcf 7 cells |
| topic | antioxidant capacity antiproliferative potential breast cancer phenolic compounds traditional medicinal plants |
| url | https://doi.org/10.2478/ebtj-2020-0012 |
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