Potential anti neuro‐inflammatory effect of BioCen‐128 in animal models of dementia
Abstract Background BioCen‐128 is a new active pharmaceutical ingredient composed of a specific bovine thymic fraction of a polypeptide nature. Positive results of similar thymus extracts have been shown to be effective in delaying the processes associated with aging, immunosenescence and Alzheimer&...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-08-01
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| Series: | Animal Models and Experimental Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ame2.12267 |
| _version_ | 1811185620806008832 |
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| author | Nashelly Esquivel Yenela García Roberto Menéndez Teidy E. García Ana R. Morales Claudio Rodríguez |
| author_facet | Nashelly Esquivel Yenela García Roberto Menéndez Teidy E. García Ana R. Morales Claudio Rodríguez |
| author_sort | Nashelly Esquivel |
| collection | DOAJ |
| description | Abstract Background BioCen‐128 is a new active pharmaceutical ingredient composed of a specific bovine thymic fraction of a polypeptide nature. Positive results of similar thymus extracts have been shown to be effective in delaying the processes associated with aging, immunosenescence and Alzheimer's disease (AD), where the inflammation plays an important role. Because of the anti‐inflammatory potential of BioCen‐128, the aim of this study was to evaluate the granuloma model induced by a cotton wool implantation and the model induced by intracerebroventricular (ICV) administration of streptozotocin (STZ). Method The experiment was carried out using male OF‐1cenp mice weighing 20 ± 2 g. Results Mice administered BioCen‐128 in via the IP route at 5, 10 and 20 mg/kg of corporal weigh showed a decrease in the wet and dry weights of the granuloma, providing evidence of a systemic anti‐inflammatory effect. In the ICV model of STZ, the administration of BioCen‐128 improved cognitive function. Conclusion These responses suggested an anti‐neuroinflammatory effect explainable by the action of thymosin β4 and thymosin alfa proteins. The results suggested that BioCen‐128 could be used in the prevention and treatment of some diseases, for example AD, where neuroinflammation is one of the biological events that take place. |
| first_indexed | 2024-04-11T13:33:22Z |
| format | Article |
| id | doaj.art-838631d7c15948b7a6afcf5f1987cb45 |
| institution | Directory Open Access Journal |
| issn | 2576-2095 |
| language | English |
| last_indexed | 2024-04-11T13:33:22Z |
| publishDate | 2022-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Animal Models and Experimental Medicine |
| spelling | doaj.art-838631d7c15948b7a6afcf5f1987cb452022-12-22T04:21:43ZengWileyAnimal Models and Experimental Medicine2576-20952022-08-015436937610.1002/ame2.12267Potential anti neuro‐inflammatory effect of BioCen‐128 in animal models of dementiaNashelly Esquivel0Yenela García1Roberto Menéndez2Teidy E. García3Ana R. Morales4Claudio Rodríguez5National Center for Bioproducts (BIOCEN) Bejucal CubaNational Center for Bioproducts (BIOCEN) Bejucal CubaCenter for Neurosciences (CNEURO) Playa CubaCenter for Neurosciences (CNEURO) Playa CubaDepartment of Pharmacology Institute of Marine Sciences (ICIMAR) Havana CubaNational Center for Bioproducts (BIOCEN) Bejucal CubaAbstract Background BioCen‐128 is a new active pharmaceutical ingredient composed of a specific bovine thymic fraction of a polypeptide nature. Positive results of similar thymus extracts have been shown to be effective in delaying the processes associated with aging, immunosenescence and Alzheimer's disease (AD), where the inflammation plays an important role. Because of the anti‐inflammatory potential of BioCen‐128, the aim of this study was to evaluate the granuloma model induced by a cotton wool implantation and the model induced by intracerebroventricular (ICV) administration of streptozotocin (STZ). Method The experiment was carried out using male OF‐1cenp mice weighing 20 ± 2 g. Results Mice administered BioCen‐128 in via the IP route at 5, 10 and 20 mg/kg of corporal weigh showed a decrease in the wet and dry weights of the granuloma, providing evidence of a systemic anti‐inflammatory effect. In the ICV model of STZ, the administration of BioCen‐128 improved cognitive function. Conclusion These responses suggested an anti‐neuroinflammatory effect explainable by the action of thymosin β4 and thymosin alfa proteins. The results suggested that BioCen‐128 could be used in the prevention and treatment of some diseases, for example AD, where neuroinflammation is one of the biological events that take place.https://doi.org/10.1002/ame2.12267BioCen‐128cotton pelletmiceneuroinflammation |
| spellingShingle | Nashelly Esquivel Yenela García Roberto Menéndez Teidy E. García Ana R. Morales Claudio Rodríguez Potential anti neuro‐inflammatory effect of BioCen‐128 in animal models of dementia Animal Models and Experimental Medicine BioCen‐128 cotton pellet mice neuroinflammation |
| title | Potential anti neuro‐inflammatory effect of BioCen‐128 in animal models of dementia |
| title_full | Potential anti neuro‐inflammatory effect of BioCen‐128 in animal models of dementia |
| title_fullStr | Potential anti neuro‐inflammatory effect of BioCen‐128 in animal models of dementia |
| title_full_unstemmed | Potential anti neuro‐inflammatory effect of BioCen‐128 in animal models of dementia |
| title_short | Potential anti neuro‐inflammatory effect of BioCen‐128 in animal models of dementia |
| title_sort | potential anti neuro inflammatory effect of biocen 128 in animal models of dementia |
| topic | BioCen‐128 cotton pellet mice neuroinflammation |
| url | https://doi.org/10.1002/ame2.12267 |
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