Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway
Genetic variants in Granulin (GRN), which encodes the secreted glycoprotein progranulin (PGRN), are associated with several neurodegenerative diseases, including frontotemporal lobar degeneration, neuronal ceroid lipofuscinosis, and Alzheimer’s disease. These genetic alterations manifest in patholog...
Main Authors: | Tingting Dong, Leon Tejwani, Youngseob Jung, Hiroshi Kokubu, Kimberly Luttik, Terri M. Driessen, Janghoo Lim |
---|---|
Format: | Article |
Language: | English |
Published: |
American Society for Clinical investigation
2021-11-01
|
Series: | JCI Insight |
Subjects: | |
Online Access: | https://doi.org/10.1172/jci.insight.136147 |
Similar Items
-
Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43–related neurodegeneration
by: Leon Tejwani, et al.
Published: (2023-08-01) -
Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia
by: Wonjae Sung, et al.
Published: (2024-02-01) -
Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction
by: Fannie W. Chen, et al.
Published: (2022-09-01) -
SorCS2 binds progranulin to regulate motor neuron development
by: Pernille Bogetofte Thomasen, et al.
Published: (2023-11-01) -
Lipidomic and Transcriptomic Basis of Lysosomal Dysfunction in Progranulin Deficiency
by: Bret M. Evers, et al.
Published: (2017-09-01)