Vitamin D and glycemic control in diabetes mellitus type 2
Objectives: The extraskeletal effects of vitamin D have attracted considerable interest. Vitamin D deficiency appears to be related to the development of diabetes mellitus type 2 and the metabolic syndrome. Vitamin D may affect glucose homeostasis, vitamin D levels having been found to be inversely...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2013-08-01
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| Series: | Therapeutic Advances in Endocrinology and Metabolism |
| Online Access: | https://doi.org/10.1177/2042018813501189 |
| _version_ | 1818256542559895552 |
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| author | Ifigenia Kostoglou-Athanassiou Panagiotis Athanassiou Anastasios Gkountouvas Philippos Kaldrymides |
| author_facet | Ifigenia Kostoglou-Athanassiou Panagiotis Athanassiou Anastasios Gkountouvas Philippos Kaldrymides |
| author_sort | Ifigenia Kostoglou-Athanassiou |
| collection | DOAJ |
| description | Objectives: The extraskeletal effects of vitamin D have attracted considerable interest. Vitamin D deficiency appears to be related to the development of diabetes mellitus type 2 and the metabolic syndrome. Vitamin D may affect glucose homeostasis, vitamin D levels having been found to be inversely related to glycosylated hemoglobin levels in gestational diabetes mellitus. In addition, vitamin D appears to protect from the development of gestational diabetes mellitus. The aim was to study levels of 25-hydroxy vitamin D 3 [25(OH)D 3 ] and the relationship between 25(OH)D 3 levels and glycemic control in patients with diabetes mellitus type 2. Methods: Glycosylated hemoglobin (HbA1 c ) and 25(OH)D 3 levels were measured in a group of 120 diabetes mellitus type 2 patients. The same measurements were performed in a group of 120 control subjects of the same age and sex. 25(OH)D 3 was measured by radioimmunoassay and glycosylated hemoglobin (HbA1 c ) was measured by high-performance liquid chromatography. Results: 25(OH)D 3 levels were lower in the diabetes mellitus type 2 patients than in the control group, being 19.26 ± 0.95 ng/ml and 25.49 ± 1.02 ng/ml, in the patient and control groups, respectively ( p < 0.001, Student’s t -test). 25(OH)D 3 levels were found to be inversely associated with HbA1 c levels in the diabetic patients ( p = 0.008, r 2 = 0.058, linear regression). 25(OH)D 3 levels were found to be inversely associated with HbA1 c when the patient and control groups were analysed together ( p < 0.001, r 2 = 0.086). Conclusions: Vitamin D levels appeared to be lower in diabetes mellitus type 2 patients than in the control group, vitamin D levels being related to glycemic control in diabetes mellitus type 2. These findings may have therapeutic implications as cautious vitamin D supplementation may improve glycemic control in diabetes mellitus type 2. |
| first_indexed | 2024-12-12T17:29:25Z |
| format | Article |
| id | doaj.art-8388252d4e0b4f64a47b9a0802dc6077 |
| institution | Directory Open Access Journal |
| issn | 2042-0188 2042-0196 |
| language | English |
| last_indexed | 2024-12-12T17:29:25Z |
| publishDate | 2013-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Endocrinology and Metabolism |
| spelling | doaj.art-8388252d4e0b4f64a47b9a0802dc60772022-12-22T00:17:25ZengSAGE PublishingTherapeutic Advances in Endocrinology and Metabolism2042-01882042-01962013-08-01410.1177/2042018813501189Vitamin D and glycemic control in diabetes mellitus type 2Ifigenia Kostoglou-AthanassiouPanagiotis AthanassiouAnastasios GkountouvasPhilippos KaldrymidesObjectives: The extraskeletal effects of vitamin D have attracted considerable interest. Vitamin D deficiency appears to be related to the development of diabetes mellitus type 2 and the metabolic syndrome. Vitamin D may affect glucose homeostasis, vitamin D levels having been found to be inversely related to glycosylated hemoglobin levels in gestational diabetes mellitus. In addition, vitamin D appears to protect from the development of gestational diabetes mellitus. The aim was to study levels of 25-hydroxy vitamin D 3 [25(OH)D 3 ] and the relationship between 25(OH)D 3 levels and glycemic control in patients with diabetes mellitus type 2. Methods: Glycosylated hemoglobin (HbA1 c ) and 25(OH)D 3 levels were measured in a group of 120 diabetes mellitus type 2 patients. The same measurements were performed in a group of 120 control subjects of the same age and sex. 25(OH)D 3 was measured by radioimmunoassay and glycosylated hemoglobin (HbA1 c ) was measured by high-performance liquid chromatography. Results: 25(OH)D 3 levels were lower in the diabetes mellitus type 2 patients than in the control group, being 19.26 ± 0.95 ng/ml and 25.49 ± 1.02 ng/ml, in the patient and control groups, respectively ( p < 0.001, Student’s t -test). 25(OH)D 3 levels were found to be inversely associated with HbA1 c levels in the diabetic patients ( p = 0.008, r 2 = 0.058, linear regression). 25(OH)D 3 levels were found to be inversely associated with HbA1 c when the patient and control groups were analysed together ( p < 0.001, r 2 = 0.086). Conclusions: Vitamin D levels appeared to be lower in diabetes mellitus type 2 patients than in the control group, vitamin D levels being related to glycemic control in diabetes mellitus type 2. These findings may have therapeutic implications as cautious vitamin D supplementation may improve glycemic control in diabetes mellitus type 2.https://doi.org/10.1177/2042018813501189 |
| spellingShingle | Ifigenia Kostoglou-Athanassiou Panagiotis Athanassiou Anastasios Gkountouvas Philippos Kaldrymides Vitamin D and glycemic control in diabetes mellitus type 2 Therapeutic Advances in Endocrinology and Metabolism |
| title | Vitamin D and glycemic control in diabetes mellitus type 2 |
| title_full | Vitamin D and glycemic control in diabetes mellitus type 2 |
| title_fullStr | Vitamin D and glycemic control in diabetes mellitus type 2 |
| title_full_unstemmed | Vitamin D and glycemic control in diabetes mellitus type 2 |
| title_short | Vitamin D and glycemic control in diabetes mellitus type 2 |
| title_sort | vitamin d and glycemic control in diabetes mellitus type 2 |
| url | https://doi.org/10.1177/2042018813501189 |
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