Gait analysis in chemotherapy-induced peripheral neurotoxicity rodent models
Gait analysis could be used in animal models as an indicator of sensory ataxia due to chemotherapy-induced peripheral neurotoxicity (CIPN). Over the years, gait analysis in in vivo studies has evolved from simple observations carried out by a trained operator to computerised systems with machine lea...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
|
| Series: | Brain Research Bulletin |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923023001946 |
| _version_ | 1827791733396602880 |
|---|---|
| author | Maria Lopez-Garzon Annalisa Canta Alessia Chiorazzi Paola Alberti |
| author_facet | Maria Lopez-Garzon Annalisa Canta Alessia Chiorazzi Paola Alberti |
| author_sort | Maria Lopez-Garzon |
| collection | DOAJ |
| description | Gait analysis could be used in animal models as an indicator of sensory ataxia due to chemotherapy-induced peripheral neurotoxicity (CIPN). Over the years, gait analysis in in vivo studies has evolved from simple observations carried out by a trained operator to computerised systems with machine learning that allow the quantification of any variable of interest and the establishment of algorithms for behavioural classification. However, there is not a consensus on gait analysis use in CIPN animal models; therefore, we carried out a systematic review. Of 987 potentially relevant studies, 14 were included, in which different methods were analysed (observation, footprint and CatWalk™). We presented the state-of-the-art of possible approaches to analyse sensory ataxia in rodent models, addressing advantages and disadvantages of different methods available. Semi-automated methods may be of interest when preventive or therapeutic strategies are evaluated, also considering their methodological simplicity and automaticity; up to now, only CatWalk™ analysis has been tested. Future studies should expect that CIPN-affected animals tend to reduce hind paw support due to pain, allodynia or loss of sensation, and an increase in swing phase could or should be observed. Few available studies documented these impairments at the last time point, and only appeared later on respect to other earlier signs of CIPN (such as altered neurophysiological findings). For that reason, gait impairment could be interpreted as late repercussions of loss of sensory. |
| first_indexed | 2024-03-11T17:52:01Z |
| format | Article |
| id | doaj.art-83884751a16743daa917901c6448a974 |
| institution | Directory Open Access Journal |
| issn | 1873-2747 |
| language | English |
| last_indexed | 2024-03-11T17:52:01Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj.art-83884751a16743daa917901c6448a9742023-10-18T04:30:19ZengElsevierBrain Research Bulletin1873-27472023-10-01203110769Gait analysis in chemotherapy-induced peripheral neurotoxicity rodent modelsMaria Lopez-Garzon0Annalisa Canta1Alessia Chiorazzi2Paola Alberti3Biomedical Group (BIO277), Department of Physiotherapy, Faculty of Health Sciences, University of Granada, Granada, Spain; A02-Cuídate, Instituto de Investigación Biosanitaria Ibs, GRANADA, Granada, Spain; Unit of Excellence On Exercise and Health (UCEES), University of Granada, Granada, Spain; Sport and Health Research Center (IMUDs), Granada, SpainExperimental Neurology Unit, School of Medicine and Surgery, Monza, Italy; NeuroMI (Milan Center for neuroscience), Milan, ItalyExperimental Neurology Unit, School of Medicine and Surgery, Monza, Italy; NeuroMI (Milan Center for neuroscience), Milan, ItalyExperimental Neurology Unit, School of Medicine and Surgery, Monza, Italy; NeuroMI (Milan Center for neuroscience), Milan, Italy; Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; Correspondence to: School of Medicine and Surgery, University of Milano-Bicocca, U8 Building, 1st floor, Room 1034, Via Cadore, 48, 20900 Monza, Italy.Gait analysis could be used in animal models as an indicator of sensory ataxia due to chemotherapy-induced peripheral neurotoxicity (CIPN). Over the years, gait analysis in in vivo studies has evolved from simple observations carried out by a trained operator to computerised systems with machine learning that allow the quantification of any variable of interest and the establishment of algorithms for behavioural classification. However, there is not a consensus on gait analysis use in CIPN animal models; therefore, we carried out a systematic review. Of 987 potentially relevant studies, 14 were included, in which different methods were analysed (observation, footprint and CatWalk™). We presented the state-of-the-art of possible approaches to analyse sensory ataxia in rodent models, addressing advantages and disadvantages of different methods available. Semi-automated methods may be of interest when preventive or therapeutic strategies are evaluated, also considering their methodological simplicity and automaticity; up to now, only CatWalk™ analysis has been tested. Future studies should expect that CIPN-affected animals tend to reduce hind paw support due to pain, allodynia or loss of sensation, and an increase in swing phase could or should be observed. Few available studies documented these impairments at the last time point, and only appeared later on respect to other earlier signs of CIPN (such as altered neurophysiological findings). For that reason, gait impairment could be interpreted as late repercussions of loss of sensory.http://www.sciencedirect.com/science/article/pii/S0361923023001946Chemotherapy-induced peripheral neuropathyChemotherapy-induced peripheral neurotoxicityGait analysisAnimal modelsSensory ataxiaPhysical therapy |
| spellingShingle | Maria Lopez-Garzon Annalisa Canta Alessia Chiorazzi Paola Alberti Gait analysis in chemotherapy-induced peripheral neurotoxicity rodent models Brain Research Bulletin Chemotherapy-induced peripheral neuropathy Chemotherapy-induced peripheral neurotoxicity Gait analysis Animal models Sensory ataxia Physical therapy |
| title | Gait analysis in chemotherapy-induced peripheral neurotoxicity rodent models |
| title_full | Gait analysis in chemotherapy-induced peripheral neurotoxicity rodent models |
| title_fullStr | Gait analysis in chemotherapy-induced peripheral neurotoxicity rodent models |
| title_full_unstemmed | Gait analysis in chemotherapy-induced peripheral neurotoxicity rodent models |
| title_short | Gait analysis in chemotherapy-induced peripheral neurotoxicity rodent models |
| title_sort | gait analysis in chemotherapy induced peripheral neurotoxicity rodent models |
| topic | Chemotherapy-induced peripheral neuropathy Chemotherapy-induced peripheral neurotoxicity Gait analysis Animal models Sensory ataxia Physical therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0361923023001946 |
| work_keys_str_mv | AT marialopezgarzon gaitanalysisinchemotherapyinducedperipheralneurotoxicityrodentmodels AT annalisacanta gaitanalysisinchemotherapyinducedperipheralneurotoxicityrodentmodels AT alessiachiorazzi gaitanalysisinchemotherapyinducedperipheralneurotoxicityrodentmodels AT paolaalberti gaitanalysisinchemotherapyinducedperipheralneurotoxicityrodentmodels |