The serotonin receptor 7 and the structural plasticity of brain circuits
Serotonin (5-hydroxytryptamine, 5-HT) modulates numerous physiological processes in the nervous system. Together with its function as neurotrasmitter, 5-HT regulates neurite outgrowth, dendritic spine shape and density, growth cone motility and synapse formation during development. In the mammalian...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-09-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00318/full |
| _version_ | 1818881717326315520 |
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| author | Floriana eVolpicelli Floriana eVolpicelli Luisa eSperanza Umberto edi Porzio Marianna eCrispino Carla ePerrone-Capano Carla ePerrone-Capano |
| author_facet | Floriana eVolpicelli Floriana eVolpicelli Luisa eSperanza Umberto edi Porzio Marianna eCrispino Carla ePerrone-Capano Carla ePerrone-Capano |
| author_sort | Floriana eVolpicelli |
| collection | DOAJ |
| description | Serotonin (5-hydroxytryptamine, 5-HT) modulates numerous physiological processes in the nervous system. Together with its function as neurotrasmitter, 5-HT regulates neurite outgrowth, dendritic spine shape and density, growth cone motility and synapse formation during development. In the mammalian brain 5-HT innervation is virtually ubiquitous and the diversity and specificity of its signaling and function arise from at least 20 different receptors, grouped in 7 classes. Here we will focus on the role 5-HT7 receptor (5-HT7R) in the correct establishment of neuronal cytoarchitecture during development, as also suggested by its involvement in several neurodevelopmental disorders. The emerging picture shows that this receptor is a key player contributing not only to shape brain networks during development but also to remodel neuronal wiring in the mature brain, thus controlling cognitive and emotional responses. The activation of 5-HT7R might be one of the mechanisms underlying the ability of the CNS to respond to different stimuli by modulation of its circuit configuration. |
| first_indexed | 2024-12-19T15:06:18Z |
| format | Article |
| id | doaj.art-8388cca7de854df195cabf7fb103c3f0 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-19T15:06:18Z |
| publishDate | 2014-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-8388cca7de854df195cabf7fb103c3f02022-12-21T20:16:26ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532014-09-01810.3389/fnbeh.2014.00318110751The serotonin receptor 7 and the structural plasticity of brain circuitsFloriana eVolpicelli0Floriana eVolpicelli1Luisa eSperanza2Umberto edi Porzio3Marianna eCrispino4Carla ePerrone-Capano5Carla ePerrone-Capano6University of Naples Federico IIInstitute of Genetics and Biophysics “Adriano Buzzati Traverso”, CNRInstitute of Genetics and Biophysics “Adriano Buzzati Traverso”, CNRInstitute of Genetics and Biophysics “Adriano Buzzati Traverso”, CNRUniversity of Naples Federico IIUniversity of Naples Federico IIInstitute of Genetics and Biophysics “Adriano Buzzati Traverso”, CNRSerotonin (5-hydroxytryptamine, 5-HT) modulates numerous physiological processes in the nervous system. Together with its function as neurotrasmitter, 5-HT regulates neurite outgrowth, dendritic spine shape and density, growth cone motility and synapse formation during development. In the mammalian brain 5-HT innervation is virtually ubiquitous and the diversity and specificity of its signaling and function arise from at least 20 different receptors, grouped in 7 classes. Here we will focus on the role 5-HT7 receptor (5-HT7R) in the correct establishment of neuronal cytoarchitecture during development, as also suggested by its involvement in several neurodevelopmental disorders. The emerging picture shows that this receptor is a key player contributing not only to shape brain networks during development but also to remodel neuronal wiring in the mature brain, thus controlling cognitive and emotional responses. The activation of 5-HT7R might be one of the mechanisms underlying the ability of the CNS to respond to different stimuli by modulation of its circuit configuration.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00318/fullSerotoninBrain Developmentbrain connectivityneurodevelopmental diseases5-HT7Rneuronal cytoarchitecture |
| spellingShingle | Floriana eVolpicelli Floriana eVolpicelli Luisa eSperanza Umberto edi Porzio Marianna eCrispino Carla ePerrone-Capano Carla ePerrone-Capano The serotonin receptor 7 and the structural plasticity of brain circuits Frontiers in Behavioral Neuroscience Serotonin Brain Development brain connectivity neurodevelopmental diseases 5-HT7R neuronal cytoarchitecture |
| title | The serotonin receptor 7 and the structural plasticity of brain circuits |
| title_full | The serotonin receptor 7 and the structural plasticity of brain circuits |
| title_fullStr | The serotonin receptor 7 and the structural plasticity of brain circuits |
| title_full_unstemmed | The serotonin receptor 7 and the structural plasticity of brain circuits |
| title_short | The serotonin receptor 7 and the structural plasticity of brain circuits |
| title_sort | serotonin receptor 7 and the structural plasticity of brain circuits |
| topic | Serotonin Brain Development brain connectivity neurodevelopmental diseases 5-HT7R neuronal cytoarchitecture |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00318/full |
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