Lactate Dehydrogenase and Risk of Readmission with Gastric Cancer: A Propensity Score Matching Analysis
Purpose Readmission is one of the measures of quality of care and potential costs. This study aimed to determine whether lactate dehydrogenase (LDH) is associated with an increased risk of 30-day readmission in gastric cancer. Methods We performed a retrospective study of patients who underwent radi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-01-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2023.2172488 |
| _version_ | 1797684413846257664 |
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| author | Wei-Sheng Chen Ze-Xin Huang Hui-Hui Zhang Xiao-Dong Chen Yi-Qi Cai Wen-Jing Chen Guan-Bao Zhu Yun-Shi Huang |
| author_facet | Wei-Sheng Chen Ze-Xin Huang Hui-Hui Zhang Xiao-Dong Chen Yi-Qi Cai Wen-Jing Chen Guan-Bao Zhu Yun-Shi Huang |
| author_sort | Wei-Sheng Chen |
| collection | DOAJ |
| description | Purpose Readmission is one of the measures of quality of care and potential costs. This study aimed to determine whether lactate dehydrogenase (LDH) is associated with an increased risk of 30-day readmission in gastric cancer. Methods We performed a retrospective study of patients who underwent radical gastrectomy for gastric cancer at our institution between July 2014 and May 2018. Balanced cohorts were created by propensity score matching (PSM) with a 1:1 ratio to generate the elevated LDH (ELDH) group (n = 151) and the low LDH group (Control) (n = 302). To determine the incidence, causes, and risk factors of 30-day readmission, subgroup analyzes were performed and used to develop an efficient prediction model. Results A total of 788 patients met the criteria to be included in the study. The cutoff value for serum LDH was 215.5. After PSM, a total of 302 patients were matched in pairs (ELDH group, n = 151, Control group, n = 151). ELDH levels had a higher risk of readmission (p = 0.005, Odds ratio 3.768, 95% confidence interval 1.493–9.510). The pre-match 30-day readmission rate was 7.2 percent, and common causes of post-match readmission included infection-related symptoms, gastrointestinal symptoms, and gastrointestinal bleeding. Conclusions Patients with preoperative ELDH levels, postoperative complications, and high preoperative American Society of Anesthesiologists Scores had a higher risk of readmission 30 days after surgery. |
| first_indexed | 2024-03-12T00:30:17Z |
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| id | doaj.art-838a19570b19483baf246d48f5e36ab0 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:30:17Z |
| publishDate | 2023-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-838a19570b19483baf246d48f5e36ab02023-09-15T10:21:31ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532023-01-010010.1080/08941939.2023.21724882172488Lactate Dehydrogenase and Risk of Readmission with Gastric Cancer: A Propensity Score Matching AnalysisWei-Sheng Chen0Ze-Xin Huang1Hui-Hui Zhang2Xiao-Dong Chen3Yi-Qi Cai4Wen-Jing Chen5Guan-Bao Zhu6Yun-Shi Huang7Department of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityDepartment of Gastrointestinal Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityDepartment of Trauma & Emergency Surgery, The First Affiliated Hospital, Wenzhou Medical UniversityPurpose Readmission is one of the measures of quality of care and potential costs. This study aimed to determine whether lactate dehydrogenase (LDH) is associated with an increased risk of 30-day readmission in gastric cancer. Methods We performed a retrospective study of patients who underwent radical gastrectomy for gastric cancer at our institution between July 2014 and May 2018. Balanced cohorts were created by propensity score matching (PSM) with a 1:1 ratio to generate the elevated LDH (ELDH) group (n = 151) and the low LDH group (Control) (n = 302). To determine the incidence, causes, and risk factors of 30-day readmission, subgroup analyzes were performed and used to develop an efficient prediction model. Results A total of 788 patients met the criteria to be included in the study. The cutoff value for serum LDH was 215.5. After PSM, a total of 302 patients were matched in pairs (ELDH group, n = 151, Control group, n = 151). ELDH levels had a higher risk of readmission (p = 0.005, Odds ratio 3.768, 95% confidence interval 1.493–9.510). The pre-match 30-day readmission rate was 7.2 percent, and common causes of post-match readmission included infection-related symptoms, gastrointestinal symptoms, and gastrointestinal bleeding. Conclusions Patients with preoperative ELDH levels, postoperative complications, and high preoperative American Society of Anesthesiologists Scores had a higher risk of readmission 30 days after surgery.http://dx.doi.org/10.1080/08941939.2023.2172488serum lactate dehydrogenasepostoperative complicationsgastric cancerreadmissionpropensity score matching |
| spellingShingle | Wei-Sheng Chen Ze-Xin Huang Hui-Hui Zhang Xiao-Dong Chen Yi-Qi Cai Wen-Jing Chen Guan-Bao Zhu Yun-Shi Huang Lactate Dehydrogenase and Risk of Readmission with Gastric Cancer: A Propensity Score Matching Analysis Journal of Investigative Surgery serum lactate dehydrogenase postoperative complications gastric cancer readmission propensity score matching |
| title | Lactate Dehydrogenase and Risk of Readmission with Gastric Cancer: A Propensity Score Matching Analysis |
| title_full | Lactate Dehydrogenase and Risk of Readmission with Gastric Cancer: A Propensity Score Matching Analysis |
| title_fullStr | Lactate Dehydrogenase and Risk of Readmission with Gastric Cancer: A Propensity Score Matching Analysis |
| title_full_unstemmed | Lactate Dehydrogenase and Risk of Readmission with Gastric Cancer: A Propensity Score Matching Analysis |
| title_short | Lactate Dehydrogenase and Risk of Readmission with Gastric Cancer: A Propensity Score Matching Analysis |
| title_sort | lactate dehydrogenase and risk of readmission with gastric cancer a propensity score matching analysis |
| topic | serum lactate dehydrogenase postoperative complications gastric cancer readmission propensity score matching |
| url | http://dx.doi.org/10.1080/08941939.2023.2172488 |
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