The Effect of Vicinal Difluorination on the Conformation and Potency of Histone Deacetylase Inhibitors

The Effect of Vicinal Difluorination on the Conformation and Potency of Histone Deacetylase Inhibitors

Histone deacetylase enzymes (HDACs) are potential targets for the treatment of cancer and other diseases, but it is challenging to design isoform-selective agents. In this work, we created new analogs of two established but non-selective HDAC inhibitors. We decorated the central linker chains of the...

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Bibliographic Details
Main Authors: A. Daryl Ariawan, Flora Mansour, Nicole Richardson, Mohan Bhadbhade, Junming Ho, Luke Hunter
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
SAHA
Scriptaid
stereoselective fluorination
HDAC
Online Access:https://www.mdpi.com/1420-3049/26/13/3974

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