Romidepsin controls chronic lymphocytic leukemia in a patient with mycosis fungoides
Romidepsin belongs to a class of medications called histone deacetylase inhibitors and is currently approved for treatment of cutaneous and peripheral T-cell lymphomas. Romidepsin was previously investigated for the treatment of chronic lymphocytic leukemia (CLL), and demonstrated potential benefit,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2016-11-01
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| Series: | Hematology Reports |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/hr/article/view/6840 |
| _version_ | 1797936758397075456 |
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| author | David M. Lemchak Oleg E. Akilov |
| author_facet | David M. Lemchak Oleg E. Akilov |
| author_sort | David M. Lemchak |
| collection | DOAJ |
| description | Romidepsin belongs to a class of medications called histone deacetylase inhibitors and is currently approved for treatment of cutaneous and peripheral T-cell lymphomas. Romidepsin was previously investigated for the treatment of chronic lymphocytic leukemia (CLL), and demonstrated potential benefit, but interest in its use declined following phase I clinical trials that showed poor tolerance of a significant side effect profile. We presented a patient with a history of stage II CLL, referred to dermatology for treatment of new-onset of mycosis fungoides (MF), who was treated with romidepsin over seven months. The patient achieved a partial response with 50% decrease in body surface area occupied by MF, thinning of remaining plaques, and near complete response in his CLL. His absolute lymphocyte count remained within the normal range for four months following discontinuation of romidepsin. Side effects were well-tolerated and did not limit therapy. Current literature on romidepsin is reviewed and compared to existing treatments for CLL. |
| first_indexed | 2024-04-10T18:34:17Z |
| format | Article |
| id | doaj.art-838b235229f14d858d0fe2caf061a54c |
| institution | Directory Open Access Journal |
| issn | 2038-8322 2038-8330 |
| language | English |
| last_indexed | 2024-04-10T18:34:17Z |
| publishDate | 2016-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Hematology Reports |
| spelling | doaj.art-838b235229f14d858d0fe2caf061a54c2023-02-02T02:03:42ZengMDPI AGHematology Reports2038-83222038-83302016-11-018410.4081/hr.2016.68403568Romidepsin controls chronic lymphocytic leukemia in a patient with mycosis fungoidesDavid M. Lemchak0Oleg E. Akilov1University of Pittsburgh Medical Center Altoona, PADepartment of Dermatology, University of Pittsburgh, PARomidepsin belongs to a class of medications called histone deacetylase inhibitors and is currently approved for treatment of cutaneous and peripheral T-cell lymphomas. Romidepsin was previously investigated for the treatment of chronic lymphocytic leukemia (CLL), and demonstrated potential benefit, but interest in its use declined following phase I clinical trials that showed poor tolerance of a significant side effect profile. We presented a patient with a history of stage II CLL, referred to dermatology for treatment of new-onset of mycosis fungoides (MF), who was treated with romidepsin over seven months. The patient achieved a partial response with 50% decrease in body surface area occupied by MF, thinning of remaining plaques, and near complete response in his CLL. His absolute lymphocyte count remained within the normal range for four months following discontinuation of romidepsin. Side effects were well-tolerated and did not limit therapy. Current literature on romidepsin is reviewed and compared to existing treatments for CLL.http://www.pagepress.org/journals/index.php/hr/article/view/6840Chronic lymphocytic leukemiaHistone deacetylase inhibitorsRomidepsin |
| spellingShingle | David M. Lemchak Oleg E. Akilov Romidepsin controls chronic lymphocytic leukemia in a patient with mycosis fungoides Hematology Reports Chronic lymphocytic leukemia Histone deacetylase inhibitors Romidepsin |
| title | Romidepsin controls chronic lymphocytic leukemia in a patient with mycosis fungoides |
| title_full | Romidepsin controls chronic lymphocytic leukemia in a patient with mycosis fungoides |
| title_fullStr | Romidepsin controls chronic lymphocytic leukemia in a patient with mycosis fungoides |
| title_full_unstemmed | Romidepsin controls chronic lymphocytic leukemia in a patient with mycosis fungoides |
| title_short | Romidepsin controls chronic lymphocytic leukemia in a patient with mycosis fungoides |
| title_sort | romidepsin controls chronic lymphocytic leukemia in a patient with mycosis fungoides |
| topic | Chronic lymphocytic leukemia Histone deacetylase inhibitors Romidepsin |
| url | http://www.pagepress.org/journals/index.php/hr/article/view/6840 |
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