Presence of Varicella Zoster Virus DNA in Saliva May Be Associated with the Severity of Ramsay Hunt Syndrome
Background: The relationship between varicella zoster virus (VZV) collected from saliva and Ramsay Hunt syndrome (RHS) remains unclear. Therefore, this study aimed to investigate whether VZV DNA in saliva alters the clinical symptoms and prognosis of RHS. Methods: To measure the severity of clinical...
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MDPI AG
2022-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/9/2177 |
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| author | Gang Won Choi Junyang Jung Seung Geun Yeo Sang Hoon Kim |
| author_facet | Gang Won Choi Junyang Jung Seung Geun Yeo Sang Hoon Kim |
| author_sort | Gang Won Choi |
| collection | DOAJ |
| description | Background: The relationship between varicella zoster virus (VZV) collected from saliva and Ramsay Hunt syndrome (RHS) remains unclear. Therefore, this study aimed to investigate whether VZV DNA in saliva alters the clinical symptoms and prognosis of RHS. Methods: To measure the severity of clinical symptoms of 100 RHS patients, the initial House–Brackmann (HB) grade and associated symptoms were evaluated. The final HB grade at the end of treatment was measured to determine the prognosis. Electroneurography (ENoG) was performed on four facial muscles, including the frontalis, oculi, nasalis, and oris. Results: Salivary VZV DNA was isolated from 72 patients with RHS. The VZV DNA-positive group was 34.023 times more likely to have severe initial HB grade than the control group (95% CI, 3.21–359.68; <i>p</i> = 0.003). There were no significant differences in final HB grade. All ENoG values of the VZV DNA-positive group were significantly higher than those of the control group (frontalis, <i>p</i> = 0.003; oculi, <i>p</i> = 0.001; nasalis, <i>p</i> < 0.001; oris, <i>p</i> = 0.037). Conclusions: RHS patients with salivary VZV DNA have more severe clinical symptoms than the control group. There were no differences in prognosis and associated symptoms. A VZV DNA test using saliva samples of patients with RHS can evaluate the clinical symptoms and provide early confirmation of VZV infection, enabling timely treatment in a non-invasive way. |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:39:22Z |
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| series | Biomedicines |
| spelling | doaj.art-838d33c36dc942a4861199bb116eedc12023-11-23T15:10:21ZengMDPI AGBiomedicines2227-90592022-09-01109217710.3390/biomedicines10092177Presence of Varicella Zoster Virus DNA in Saliva May Be Associated with the Severity of Ramsay Hunt SyndromeGang Won Choi0Junyang Jung1Seung Geun Yeo2Sang Hoon Kim3Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul 02453, KoreaDepartment of Anatomy, School of Medicine, Kyung Hee University, Seoul 02453, KoreaDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul 02453, KoreaDepartment of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul 02453, KoreaBackground: The relationship between varicella zoster virus (VZV) collected from saliva and Ramsay Hunt syndrome (RHS) remains unclear. Therefore, this study aimed to investigate whether VZV DNA in saliva alters the clinical symptoms and prognosis of RHS. Methods: To measure the severity of clinical symptoms of 100 RHS patients, the initial House–Brackmann (HB) grade and associated symptoms were evaluated. The final HB grade at the end of treatment was measured to determine the prognosis. Electroneurography (ENoG) was performed on four facial muscles, including the frontalis, oculi, nasalis, and oris. Results: Salivary VZV DNA was isolated from 72 patients with RHS. The VZV DNA-positive group was 34.023 times more likely to have severe initial HB grade than the control group (95% CI, 3.21–359.68; <i>p</i> = 0.003). There were no significant differences in final HB grade. All ENoG values of the VZV DNA-positive group were significantly higher than those of the control group (frontalis, <i>p</i> = 0.003; oculi, <i>p</i> = 0.001; nasalis, <i>p</i> < 0.001; oris, <i>p</i> = 0.037). Conclusions: RHS patients with salivary VZV DNA have more severe clinical symptoms than the control group. There were no differences in prognosis and associated symptoms. A VZV DNA test using saliva samples of patients with RHS can evaluate the clinical symptoms and provide early confirmation of VZV infection, enabling timely treatment in a non-invasive way.https://www.mdpi.com/2227-9059/10/9/2177Ramsay Hunt syndromevaricella zoster virusDNA in salivaelectroneurographyfacial palsy |
| spellingShingle | Gang Won Choi Junyang Jung Seung Geun Yeo Sang Hoon Kim Presence of Varicella Zoster Virus DNA in Saliva May Be Associated with the Severity of Ramsay Hunt Syndrome Biomedicines Ramsay Hunt syndrome varicella zoster virus DNA in saliva electroneurography facial palsy |
| title | Presence of Varicella Zoster Virus DNA in Saliva May Be Associated with the Severity of Ramsay Hunt Syndrome |
| title_full | Presence of Varicella Zoster Virus DNA in Saliva May Be Associated with the Severity of Ramsay Hunt Syndrome |
| title_fullStr | Presence of Varicella Zoster Virus DNA in Saliva May Be Associated with the Severity of Ramsay Hunt Syndrome |
| title_full_unstemmed | Presence of Varicella Zoster Virus DNA in Saliva May Be Associated with the Severity of Ramsay Hunt Syndrome |
| title_short | Presence of Varicella Zoster Virus DNA in Saliva May Be Associated with the Severity of Ramsay Hunt Syndrome |
| title_sort | presence of varicella zoster virus dna in saliva may be associated with the severity of ramsay hunt syndrome |
| topic | Ramsay Hunt syndrome varicella zoster virus DNA in saliva electroneurography facial palsy |
| url | https://www.mdpi.com/2227-9059/10/9/2177 |
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