Exosomes in cancer immunoediting and immunotherapy
As an important means of communication among cells, exosomes are being studied more and more widely, especially in the context of cancer immunotherapy. In the phase of tumor immunoediting, exosomes derived from tumor cells and different immune cells have complex and changeable physiological function...
Main Authors: | , , , , , , , , |
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Format: | Article |
Language: | English |
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Elsevier
2022-03-01
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Series: | Asian Journal of Pharmaceutical Sciences |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087621001069 |
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author | Yarong Zhao Luotong Liu Rongze Sun Guilin Cui Shuyu Guo Songren Han Ziwei Li Tian Bai Lesheng Teng |
author_facet | Yarong Zhao Luotong Liu Rongze Sun Guilin Cui Shuyu Guo Songren Han Ziwei Li Tian Bai Lesheng Teng |
author_sort | Yarong Zhao |
collection | DOAJ |
description | As an important means of communication among cells, exosomes are being studied more and more widely, especially in the context of cancer immunotherapy. In the phase of tumor immunoediting, exosomes derived from tumor cells and different immune cells have complex and changeable physiological functions, because they carry different proteins and nucleic acid from the source cells. Based on the role of exosomes in the communication between different cells, cancer treatment methods are also under continuous research. This review briefly introduces the molecular composition of exosomes, which is closely related to their secretion mechanism. Subsequently, the role of exosomes encapsulating different information molecules is summarized. The role of exosomes in the three phases of tumor immunoediting is introduced in detail, and the relevant literature of exosomes in the tumor immune microenvironment is summarized by using a novel framework for extracting relevant documents. Finally, it summarizes the various exosome-based immunotherapies currently proposed, as well as the challenges and future prospects of exosomes in tumor immunotherapy. |
first_indexed | 2024-04-14T04:59:00Z |
format | Article |
id | doaj.art-838d6e39515649c08df2343d8bd127d8 |
institution | Directory Open Access Journal |
issn | 1818-0876 |
language | English |
last_indexed | 2024-04-14T04:59:00Z |
publishDate | 2022-03-01 |
publisher | Elsevier |
record_format | Article |
series | Asian Journal of Pharmaceutical Sciences |
spelling | doaj.art-838d6e39515649c08df2343d8bd127d82022-12-22T02:11:02ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762022-03-01172193205Exosomes in cancer immunoediting and immunotherapyYarong Zhao0Luotong Liu1Rongze Sun2Guilin Cui3Shuyu Guo4Songren Han5Ziwei Li6Tian Bai7Lesheng Teng8School of Life Sciences & College of Computer Science and Technology, Jilin University, Changchun 130012, ChinaSchool of Life Sciences & College of Computer Science and Technology, Jilin University, Changchun 130012, ChinaSchool of Life Sciences & College of Computer Science and Technology, Jilin University, Changchun 130012, ChinaSchool of Life Sciences & College of Computer Science and Technology, Jilin University, Changchun 130012, ChinaSchool of Life Sciences & College of Computer Science and Technology, Jilin University, Changchun 130012, ChinaSchool of Life Sciences & College of Computer Science and Technology, Jilin University, Changchun 130012, ChinaSchool of Life Sciences & College of Computer Science and Technology, Jilin University, Changchun 130012, ChinaSchool of Life Sciences & College of Computer Science and Technology, Jilin University, Changchun 130012, China; Corresponding author.School of Life Sciences & College of Computer Science and Technology, Jilin University, Changchun 130012, China; Corresponding author.As an important means of communication among cells, exosomes are being studied more and more widely, especially in the context of cancer immunotherapy. In the phase of tumor immunoediting, exosomes derived from tumor cells and different immune cells have complex and changeable physiological functions, because they carry different proteins and nucleic acid from the source cells. Based on the role of exosomes in the communication between different cells, cancer treatment methods are also under continuous research. This review briefly introduces the molecular composition of exosomes, which is closely related to their secretion mechanism. Subsequently, the role of exosomes encapsulating different information molecules is summarized. The role of exosomes in the three phases of tumor immunoediting is introduced in detail, and the relevant literature of exosomes in the tumor immune microenvironment is summarized by using a novel framework for extracting relevant documents. Finally, it summarizes the various exosome-based immunotherapies currently proposed, as well as the challenges and future prospects of exosomes in tumor immunotherapy.http://www.sciencedirect.com/science/article/pii/S1818087621001069ExosomesTumor immunoediting,Immune escapeImmunotherapy |
spellingShingle | Yarong Zhao Luotong Liu Rongze Sun Guilin Cui Shuyu Guo Songren Han Ziwei Li Tian Bai Lesheng Teng Exosomes in cancer immunoediting and immunotherapy Asian Journal of Pharmaceutical Sciences Exosomes Tumor immunoediting, Immune escape Immunotherapy |
title | Exosomes in cancer immunoediting and immunotherapy |
title_full | Exosomes in cancer immunoediting and immunotherapy |
title_fullStr | Exosomes in cancer immunoediting and immunotherapy |
title_full_unstemmed | Exosomes in cancer immunoediting and immunotherapy |
title_short | Exosomes in cancer immunoediting and immunotherapy |
title_sort | exosomes in cancer immunoediting and immunotherapy |
topic | Exosomes Tumor immunoediting, Immune escape Immunotherapy |
url | http://www.sciencedirect.com/science/article/pii/S1818087621001069 |
work_keys_str_mv | AT yarongzhao exosomesincancerimmunoeditingandimmunotherapy AT luotongliu exosomesincancerimmunoeditingandimmunotherapy AT rongzesun exosomesincancerimmunoeditingandimmunotherapy AT guilincui exosomesincancerimmunoeditingandimmunotherapy AT shuyuguo exosomesincancerimmunoeditingandimmunotherapy AT songrenhan exosomesincancerimmunoeditingandimmunotherapy AT ziweili exosomesincancerimmunoeditingandimmunotherapy AT tianbai exosomesincancerimmunoeditingandimmunotherapy AT leshengteng exosomesincancerimmunoeditingandimmunotherapy |